2G25

E. Coli Pyruvate Dehydrogenase Phosphonolactylthiamin Diphosphate Complex

Summary for 2G25

Entry DOI	10.2210/pdb2g25/pdb
Related	1L8A 1RP7
Descriptor	Pyruvate dehydrogenase E1 component, MAGNESIUM ION, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	plthdp, phosphonolactylthiamin diphosphate, pyruvate dehydrogenase e1 component, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	200964.54
Authors	Furey, W.,Arjunan, P.,Chandrasekhar, K. (deposition date: 2006-02-15, release date: 2006-04-25, Last modification date: 2023-08-30)
Primary citation	Arjunan, P.,Sax, M.,Brunskill, A.,Chandrasekhar, K.,Nemeria, N.,Zhang, S.,Jordan, F.,Furey, W. A Thiamin-bound, Pre-decarboxylation Reaction Intermediate Analogue in the Pyruvate Dehydrogenase E1 Subunit Induces Large Scale Disorder-to-Order Transformations in the Enzyme and Reveals Novel Structural Features in the Covalently Bound Adduct. J.Biol.Chem., 281:15296-15303, 2006 Cited by PubMed: 16531404 DOI: 10.1074/jbc.M600656200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation