2G28
E. Coli Pyruvate Dehydrogenase H407A variant Phosphonolactylthiamin Diphosphate Complex
Summary for 2G28
Entry DOI | 10.2210/pdb2g28/pdb |
Related | 1L8A 1RP7 |
Descriptor | Pyruvate dehydrogenase E1 component, MAGNESIUM ION, 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, ... (4 entities in total) |
Functional Keywords | plthdp, phosphonolactylthiamin diphosphate, pyruvate dehydrogenase e1 component, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 200489.68 |
Authors | Furey, W.,Arjunan, P.,Chandrasekhar, K. (deposition date: 2006-02-15, release date: 2006-04-25, Last modification date: 2023-08-30) |
Primary citation | Arjunan, P.,Sax, M.,Brunskill, A.,Chandrasekhar, K.,Nemeria, N.,Zhang, S.,Jordan, F.,Furey, W. A Thiamin-bound, Pre-decarboxylation Reaction Intermediate Analogue in the Pyruvate Dehydrogenase E1 Subunit Induces Large Scale Disorder-to-Order Transformations in the Enzyme and Reveals Novel Structural Features in the Covalently Bound Adduct. J.Biol.Chem., 281:15296-15303, 2006 Cited by PubMed: 16531404DOI: 10.1074/jbc.M600656200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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