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5UWT
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BU of 5uwt by Molmil
Crystal Structure of Hxk2 Peptide in complex with CRM1 K579A mutant-Ran-RanBP1
Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.342 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWS
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BU of 5uws by Molmil
Crystal Structure of X11L2 NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Amyloid beta A4 precursor protein-binding family A member 3, Exportin-1,Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5DH9
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BU of 5dh9 by Molmil
Crystal Structure of PKI NES Flip Mutant Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Engineered Nuclear Export Signal Peptide (PKINES-Flip3 mutant), Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y, Chook, Y.M.
Deposit date:2015-08-30
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015
5DHA
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BU of 5dha by Molmil
Crystal Structure of CPEB4 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Engineered Nuclear Export Signal Peptide (CPEB4 NES reverse mutant), Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y, Chook, Y.M.
Deposit date:2015-08-30
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015
5DIF
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BU of 5dif by Molmil
Crystal Structure of CPEB4 NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, Cytoplasmic polyadenylation element-binding protein 4, Exportin-1, ...
Authors:Fung, H.Y, Chook, Y.M.
Deposit date:2015-08-31
Release date:2015-09-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015
5DI9
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BU of 5di9 by Molmil
Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ...
Authors:Fung, H.Y, Chook, Y.M.
Deposit date:2015-08-31
Release date:2015-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015
5DHF
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BU of 5dhf by Molmil
Crystal Structure of hRio2 NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y, Chook, Y.M.
Deposit date:2015-08-30
Release date:2015-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015
5UWI
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BU of 5uwi by Molmil
Crystal Structure of HDAC5 NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.143 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWU
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BU of 5uwu by Molmil
Crystal Structure of SMAD4 NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWQ
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BU of 5uwq by Molmil
Crystal Structure of CDC7 NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Cell division cycle 7-related protein kinase, Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.278 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWW
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BU of 5uww by Molmil
Crystal Structure of DEAF1 Peptide in complex with CRM1 K579A mutant-Ran-RanBP1
Descriptor: Deformed epidermal autoregulatory factor 1 homolog, Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.152 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWJ
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BU of 5uwj by Molmil
Crystal Structure of FMRP NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.221 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWR
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BU of 5uwr by Molmil
Crystal Structure of CDC7 NES Peptide (extended) in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, Cell division cycle 7-related protein kinase, Exportin-1, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWP
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BU of 5uwp by Molmil
Crystal Structure of mDia2 NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWO
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BU of 5uwo by Molmil
Crystal Structure of Engineered FMRP-1b NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Engineered FMRP-1b peptide, Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.347 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5UWH
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BU of 5uwh by Molmil
Crystal Structure of Paxillin NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-02-21
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
5JLJ
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BU of 5jlj by Molmil
Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1
Descriptor: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ...
Authors:Fung, H.Y, Chook, Y.M.
Deposit date:2016-04-27
Release date:2016-06-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Leukemia, 30, 2016
6CIT
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BU of 6cit by Molmil
Crystal Structure of MVM NS2 NES Peptide in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ...
Authors:Fung, H.Y.J, Chook, Y.M.
Deposit date:2018-02-25
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.027 Å)
Cite:Correlation of CRM1-NES affinity with nuclear export activity.
Mol. Biol. Cell, 29, 2018
8SGH
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BU of 8sgh by Molmil
Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, Transportin-1
Authors:Gonzalez, A, Fung, H.Y.J, Chook, Y.M.
Deposit date:2023-04-12
Release date:2023-06-14
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders.
Structure, 31, 2023
5YVG
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BU of 5yvg by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(full length)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-11-25
Release date:2018-05-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (4.05 Å)
Cite:Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
5YVH
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BU of 5yvh by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(371-526)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-11-25
Release date:2018-05-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
5YVI
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BU of 5yvi by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(456-526)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-11-25
Release date:2018-05-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
8DYO
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BU of 8dyo by Molmil
Cryo-EM structure of Importin-4 bound to RanGTP
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ...
Authors:Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M.
Deposit date:2022-08-04
Release date:2022-09-21
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
7UNK
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BU of 7unk by Molmil
Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex
Descriptor: Histone H3, Histone H4, Histone chaperone, ...
Authors:Bernardes, N.E, Chook, Y.M, Fung, H.Y.J, Chen, Z, Li, Y.
Deposit date:2022-04-11
Release date:2022-09-21
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
4WVF
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BU of 4wvf by Molmil
Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1
Descriptor: (2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Sun, Q, Chook, Y.
Deposit date:2014-11-05
Release date:2015-07-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nat.Neurosci., 18, 2015

 

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