1IGL
 
 | | SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR II RELATIONSHIP TO RECEPTOR AND BINDING PROTEIN INTERACTIONS | | Descriptor: | INSULIN-LIKE GROWTH FACTOR II | | Authors: | Torres, A.M, Forbes, B.E, Aplin, S.E, Wallace, J.C, Francis, G.L, Norton, R.S. | | Deposit date: | 1994-12-29 | | Release date: | 1995-02-14 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions.
J.Mol.Biol., 248, 1995
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2JM2
 | | Structure of the N-terminal subdomain of insulin-like growth factor (IGF) binding protein-6 and its interactions with IGFs | | Descriptor: | Insulin-like growth factor-binding protein 6 | | Authors: | Chandrashekaran, I.R, Yao, S, Wang, C.C, Bansal, P.S, Alewood, P.F, Forbes, B.E, Wallace, J.C, Bach, L.A, Norton, R.S. | | Deposit date: | 2006-09-18 | | Release date: | 2007-03-27 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | The N-Terminal Subdomain of Insulin-like Growth Factor (IGF) Binding Protein 6. Structure and Interaction with IGFs
Biochemistry, 46, 2007
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2V5P
 | | COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, INSULIN-LIKE GROWTH FACTOR II, ... | | Authors: | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | | Deposit date: | 2007-07-06 | | Release date: | 2007-12-11 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Structure and Functional Analysis of the Igf-II/Igf2R Interaction
Embo J., 27, 2008
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2V5O
 | | STRUCTURE OF HUMAN IGF2R DOMAINS 11-14 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, CHLORIDE ION | | Authors: | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | | Deposit date: | 2007-07-06 | | Release date: | 2007-12-11 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Structure and Functional Analysis of the Igf-II/Igf2R Interaction
Embo J., 27, 2008
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2V5N
 | | STRUCTURE OF HUMAN IGF2R DOMAINS 11-12 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR | | Authors: | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | | Deposit date: | 2007-07-06 | | Release date: | 2007-12-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure and Functional Analysis of the Igf-II/Igf2R Interaction
Embo J., 27, 2008
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7MQS
 | | The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation | | Descriptor: | Insulin A chain, Insulin B chain, Isoform Short of Insulin receptor | | Authors: | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | | Deposit date: | 2021-05-06 | | Release date: | 2022-03-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Nat.Chem.Biol., 18, 2022
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7MQR
 | | The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | | Authors: | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | | Deposit date: | 2021-05-06 | | Release date: | 2022-03-16 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Nat.Chem.Biol., 18, 2022
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7MQO
 | | The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, ... | | Authors: | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | | Deposit date: | 2021-05-06 | | Release date: | 2022-03-16 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Nat.Chem.Biol., 18, 2022
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5T7R
 | | A6-A11 trans-dicarba human insulin | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. | | Deposit date: | 2016-09-05 | | Release date: | 2017-12-06 | | Last modified: | 2019-06-19 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.
Sci Rep, 7, 2017
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2LLA
 | | NMR solution structure ensemble of domain 11 of the echidna M6P/IGF2R receptor | | Descriptor: | Mannose-6-phosphate/insulin-like growth factor II receptor | | Authors: | Strickland, M, Crump, M.P, Williams, C, Rezgui, D, Ellis, R.Z, Hoppe, H, Frago, S, Prince, S.N, Zaccheo, O.J, Forbes, B.E, Jones, E, Hassan, A.Z, Wattana-Amorn, P. | | Deposit date: | 2011-11-05 | | Release date: | 2012-11-07 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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5JYQ
 | | Structure of Conus Geographus insulin G1 | | Descriptor: | Insulin 1, Insulin 1b, SULFATE ION | | Authors: | Lawrence, M.C, Menting, J, Norton, R.S, Safavi-Hemami, H. | | Deposit date: | 2016-05-15 | | Release date: | 2016-09-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.
Nat.Struct.Mol.Biol., 23, 2016
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2L29
 | | Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II | | Descriptor: | Insulin-like growth factor 2 receptor variant, Insulin-like growth factor II | | Authors: | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | Deposit date: | 2010-08-13 | | Release date: | 2012-02-15 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2CNJ
 | | NMR studies on the interaction of Insulin-Growth Factor II (IGF-II) with IGF2R domain 11 | | Descriptor: | CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR | | Authors: | Williams, C, Prince, S, Zaccheo, O, Hassan, A.B, Crosby, J, Crump, M. | | Deposit date: | 2006-05-22 | | Release date: | 2007-05-22 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Insights Into the Interaction of Insulin-Like Growth Factor 2 with Igf2R Domain 11.
Structure, 15, 2007
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2L2A
 | | Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor | | Descriptor: | Insulin-like growth factor 2 receptor variant | | Authors: | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | Deposit date: | 2010-08-13 | | Release date: | 2012-02-15 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2L2G
 | | Solution structure of Opossum Domain 11 | | Descriptor: | IGF2R DOMAIN 11 | | Authors: | Williams, C, Hoppe, H, Rezgui, D, Rezgui, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Bassim, A.H. | | Deposit date: | 2010-08-18 | | Release date: | 2012-02-15 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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6VEP
 | | Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Lawrence, M.C, Menting, J.G.T. | | Deposit date: | 2020-01-02 | | Release date: | 2020-06-03 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Nat.Struct.Mol.Biol., 27, 2020
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5U8R
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2H7T
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7S8V
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7S0Q
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5U8Q
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6VET
 | | Human insulin analog: [GluB10,HisA8,ArgA9,TyrB20]-DOI | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | | Deposit date: | 2020-01-02 | | Release date: | 2020-06-03 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Nat.Struct.Mol.Biol., 27, 2020
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6VEQ
 | | Con-Ins G1 in complex with the human insulin microreceptor in turn in complex with Fv 83-7 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Con-Ins G1 B chain, Con-Ins G1a A chain, ... | | Authors: | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | | Deposit date: | 2020-01-02 | | Release date: | 2020-06-03 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Nat.Struct.Mol.Biol., 27, 2020
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6VWI
 | | Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain | | Authors: | Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. | | Deposit date: | 2020-02-19 | | Release date: | 2020-05-13 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
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6VWH
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