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1.7 A resolution structure of human cystathionine beta-synthase regulatory domain (del 516-525) in complex with SAM
分子名称:	1,2-ETHANEDIOL, CYSTATHIONINE BETA-SYNTHASE, S-ADENOSYLMETHIONINE
著者	Kopec, J, McCorvie, T.J, Fitzpatrick, F, Strain-Damerell, C, Froese, D.S, Tallant, C, Burgess-Brown, N, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W.
登録日	2014-07-31
公開日	2014-08-13
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.71 Å)
主引用文献	Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation. J.Biol.Chem., 289, 2014

2MK5

Solution structure of a protein domain
分子名称:	Endolysin
著者	Feng, Y, Gu, J.
登録日	2014-01-24
公開日	2014-05-28
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	Structural and biochemical characterization reveals LysGH15 as an unprecedented "EF-hand-like" calcium-binding phage lysin. Plos Pathog., 10, 2014

4MY5

Crystal structure of the aromatic amino acid aminotransferase from Streptococcus mutants
分子名称:	Putative amino acid aminotransferase
著者	Cong, X, Li, X, Ge, J, Feng, Y, Feng, X, Li, S.
登録日	2013-09-27
公開日	2014-10-01
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.194 Å)
主引用文献	Crystal structure of the aromatic-amino-acid aminotransferase from Streptococcus mutans. Acta Crystallogr.,Sect.F, 75, 2019

5KES

Solution structure of the yeast Ddi1 HDD domain
分子名称:	DNA damage-inducible protein 1
著者	Trempe, J.-F, Ratcliffe, C, Veverka, V, Saskova, K, Gehring, K.
登録日	2016-06-10
公開日	2016-10-05
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family. Sci Rep, 6, 2016

8WC3

Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex
分子名称:	1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WC4

Cryo-EM structure of the ZH8651-bound mTAAR1-Gs complex
分子名称:	2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WCA

Cryo-EM structure of the PEA-bound hTAAR1-Gs complex
分子名称:	2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3.48 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WC5

Cryo-EM structure of the TMA-bound mTAAR1-Gs complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WC6

Cryo-EM structure of the PEA-bound mTAAR1-Gs complex
分子名称:	2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WC9

Cryo-EM structure of the ZH8651-bound mTAAR1-Gq complex
分子名称:	2-(4-bromophenyl)ethanamine, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WCC

Cryo-EM structure of the CHA-bound mTAAR1 complex
分子名称:	CYCLOHEXYLAMMONIUM ION, Trace amine-associated receptor 1
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3.04 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WC8

Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex
分子名称:	2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (2.9 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WCB

Cryo-EM structure of the CHA-bound mTAAR1-Gq complex
分子名称:	CYCLOHEXYLAMMONIUM ION, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

8WC7

Cryo-EM structure of the ZH8667-bound mTAAR1-Gs complex
分子名称:	2-[4-(3-fluorophenyl)phenyl]ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日	2023-09-11
公開日	2023-12-27
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023

6W8I

Ternary complex structure - BTK cIAP compound 15
分子名称:	14-{[(3S)-2-(N-methyl-L-alanyl-3-methyl-L-valyl)-3-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-3,6,9,12-tetraoxatetradecan-1-yl (3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate, Baculoviral IAP repeat-containing protein 2, Tyrosine-protein kinase BTK, ...
著者	Calabrese, M.F, Schiemer, J.S.
登録日	2020-03-20
公開日	2020-11-18
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (3.8 Å)
主引用文献	Structural Characterization of BTK:PROTAC:cIAP Ternary Complexes: From Snapshots to Ensembles Nat.Chem.Biol., 2020

6W6G

The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation I in the presence of DnaK chaperone and a model substrate
分子名称:	ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者	Yin, Y, Li, H.
登録日	2020-03-16
公開日	2021-03-17
最終更新日	2021-09-29
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021

6W6H

The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation II in the presence of DnaK chaperone and a model substrate
分子名称:	ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者	Yin, Y, Li, H.
登録日	2020-03-16
公開日	2021-05-26
最終更新日	2021-12-08
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021

6W6E

The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with a locally refined ClpB middle domain and a DnaK nucleotide binding domain
分子名称:	ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, Chaperone protein DnaK, ...
著者	Yin, Y, Li, H.
登録日	2020-03-16
公開日	2021-05-26
最終更新日	2021-12-08
実験手法	ELECTRON MICROSCOPY (3.7 Å)
主引用文献	Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021

6W6J

The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with a locally refined N-terminal domain in the presence of DnaK chaperone and a model substrate
分子名称:	ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者	Yin, Y, Li, H.
登録日	2020-03-17
公開日	2021-05-26
最終更新日	2021-12-08
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021

6W6I

The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation T in the presence of DnaK chaperone and a model substrate
分子名称:	ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者	Yin, Y, Li, H.
登録日	2020-03-17
公開日	2021-05-26
最終更新日	2021-12-08
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021

8D6X

Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ATP-bound Mpa ATPase
分子名称:	AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta, ...
著者	Xiao, X, Li, H.
登録日	2022-06-06
公開日	2022-08-03
最終更新日	2022-11-09
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022

8D6V

Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of the ATP-bound Mpa ATPase
分子名称:	Proteasome subunit alpha, Proteasome subunit beta, Proteasome-associated ATPase
著者	Xiao, X, Li, H.
登録日	2022-06-06
公開日	2022-08-03
最終更新日	2022-11-09
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022

8D6Y

Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ADP-bound Mpa ATPase
分子名称:	AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta, ...
著者	Xiao, X, Li, H.
登録日	2022-06-06
公開日	2022-08-03
最終更新日	2023-08-16
実験手法	ELECTRON MICROSCOPY (10 Å)
主引用文献	The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022

8D6W

Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of the ADP-bound Mpa ATPase
分子名称:	Proteasome subunit alpha, Proteasome subunit beta, Proteasome-associated ATPase
著者	Xiao, X, Li, H.
登録日	2022-06-06
公開日	2022-08-03
最終更新日	2022-11-09
実験手法	ELECTRON MICROSCOPY (3 Å)
主引用文献	The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation. Msphere, 7, 2022

6WZW

Ash1L SET domain in complex with AS-85
分子名称:	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histone-lysine N-methyltransferase ASH1L, N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide, ...
著者	Li, H, Deng, J, Cierpicki, T, Grembecka, J.
登録日	2020-05-14
公開日	2021-04-07
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.69 Å)
主引用文献	Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12, 2021

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