6X7T
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6X9M
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6X7J
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6X7Y
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6X8Y
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6XAC
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6X7X
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6XAQ
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1DF0
| Crystal structure of M-Calpain | Descriptor: | CALPAIN, M-CALPAIN | Authors: | Hosfield, C.M, Elce, J.S, Davies, P.L, Jia, Z. | Deposit date: | 1999-11-16 | Release date: | 2000-06-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation. EMBO J., 18, 1999
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5C7R
| Revealing surface waters on an antifreeze protein by fusion protein crystallography | Descriptor: | Fusion protein of Maltose-binding periplasmic protein and Type-3 ice-structuring protein HPLC 12, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Sun, T, Gauthier, S, Campbell, R.L, Davies, P.L. | Deposit date: | 2015-06-24 | Release date: | 2015-09-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Revealing Surface Waters on an Antifreeze Protein by Fusion Protein Crystallography Combined with Molecular Dynamic Simulations. J.Phys.Chem.B, 119, 2015
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1EWW
| SOLUTION STRUCTURE OF SPRUCE BUDWORM ANTIFREEZE PROTEIN AT 30 DEGREES CELSIUS | Descriptor: | ANTIFREEZE PROTEIN | Authors: | Graether, S.P, Kuiper, M.J, Gagne, S.M, Walker, V.K, Jia, Z, Sykes, B.D, Davies, P.L. | Deposit date: | 2000-04-27 | Release date: | 2000-07-27 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Beta-helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect. Nature, 406, 2000
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2AFP
| THE SOLUTION STRUCTURE OF TYPE II ANTIFREEZE PROTEIN REVEALS A NEW MEMBER OF THE LECTIN FAMILY | Descriptor: | PROTEIN (SEA RAVEN TYPE II ANTIFREEZE PROTEIN) | Authors: | Gronwald, W, Loewen, M.C, Lix, B, Daugulis, A.J, Sonnichsen, F.D, Davies, P.L, Sykes, B.D. | Deposit date: | 1998-12-14 | Release date: | 1998-12-23 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of type II antifreeze protein reveals a new member of the lectin family. Biochemistry, 37, 1998
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4KDV
| Crystal structure of a bacterial immunoglobulin-like domain from the M. primoryensis ice-binding adhesin | Descriptor: | Antifreeze protein, CALCIUM ION | Authors: | Guo, S, Garnham, C.P, Karunan, S.P, Campbell, R.L, Allingham, J.S, Davies, P.L. | Deposit date: | 2013-04-25 | Release date: | 2013-10-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Role of Ca(2+) in folding the tandem beta-sandwich extender domains of a bacterial ice-binding adhesin. Febs J., 280, 2013
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6XNR
| Crystal structure of Rhagium Mordax antifreeze protein | Descriptor: | 1,2-ETHANEDIOL, Antifreeze protein | Authors: | Ye, Q, Eves, R, Campbell, R.L, Davies, P.L. | Deposit date: | 2020-07-04 | Release date: | 2020-08-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of an insect antifreeze protein reveals ordered waters on the ice-binding surface. Biochem.J., 477, 2020
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6XI1
| Crystal structure of tetra-tandem repeat in extending RTX adhesin from Aeromonas hydrophila | Descriptor: | CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Ye, Q, Vance, T.D.R, Conroy, B, Davies, P.L. | Deposit date: | 2020-06-19 | Release date: | 2020-10-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Essential role of calcium in extending RTX adhesins to their target. J Struct Biol X, 4, 2020
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6XI3
| Crystal structure of tetra-tandem repeat in extending region of large adhesion protein | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Ye, Q, Vance, T.D.R, Davies, P.L. | Deposit date: | 2020-06-19 | Release date: | 2020-10-14 | Last modified: | 2022-08-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Essential role of calcium in extending RTX adhesins to their target. J Struct Biol X, 4, 2020
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5MSI
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2G8J
| Calpain 1 proteolytic core in complex with SNJ-1945, a alpha-ketoamide-type inhibitor. | Descriptor: | ((1S)-1-((((1S)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2,3-DIOXOPROPYL)AMINO)CARBONYL)-3-METHYLBUTYL)CARBAMIC ACID 5-METHOXY-3-OXAPENTYL ESTER, CALCIUM ION, Calpain-1 catalytic subunit | Authors: | Cuerrier, D, Moldoveanu, T, Davies, P.L, Campbell, R.L. | Deposit date: | 2006-03-02 | Release date: | 2006-06-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography Biochemistry, 45, 2006
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2G8E
| Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Calpain-1 catalytic subunit, ... | Authors: | Cuerrier, D, Moldoveanu, T, Davies, P.L, Campbell, R.L. | Deposit date: | 2006-03-02 | Release date: | 2006-06-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography Biochemistry, 45, 2006
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1NP8
| 18-k C-terminally trunucated small subunit of calpain | Descriptor: | CADMIUM ION, Calcium-dependent protease, small subunit | Authors: | Leinala, E.K, Arthur, J.S, Grochulski, P, Davies, P.L, Elce, J.S, Jia, Z. | Deposit date: | 2003-01-17 | Release date: | 2003-11-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A second binding site revealed by C-terminal truncation of calpain small subunit, a penta-EF-hand protein PROTEINS: STRUCT.,FUNCT.,GENET., 53, 2003
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2NQI
| Calpain 1 proteolytic core inactivated by WR13(R,R), an epoxysuccinyl-type inhibitor. | Descriptor: | CALCIUM ION, Calpain-1 catalytic subunit, N~2~-[(2S)-2-{[(2R)-4-ETHOXY-2-HYDROXY-4-OXOBUTANOYL]AMINO}PENT-4-ENOYL]-L-ARGINYL-L-TRYPTOPHANAMIDE | Authors: | Cuerrier, D, Davies, P.L, Campbell, R.L, Moldoveanu, T. | Deposit date: | 2006-10-31 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries J.Biol.Chem., 282, 2007
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2NQG
| Calpain 1 proteolytic core inactivated by WR18(S,S), an epoxysuccinyl-type inhibitor. | Descriptor: | 5-AZANYLIDYNE-N-[(2S)-4-ETHOXY-2-HYDROXY-4-OXOBUTANOYL]-L-NORVALYL-L-ARGINYL-L-TRYPTOPHANAMIDE, CALCIUM ION, Calpain-1 catalytic subunit | Authors: | Cuerrier, D, Davies, P.L, Campbell, R.L, Moldoveanu, T. | Deposit date: | 2006-10-31 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries J.Biol.Chem., 282, 2007
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2MSI
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2R9C
| Calpain 1 proteolytic core inactivated by ZLAK-3001, an alpha-ketoamide | Descriptor: | CALCIUM ION, CHLORIDE ION, Calpain-1 catalytic subunit, ... | Authors: | Qian, J, Campbell, R.L, Davies, P.L. | Deposit date: | 2007-09-12 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions. J.Med.Chem., 51, 2008
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2R9F
| Calpain 1 proteolytic core inactivated by ZLAK-3002, an alpha-ketoamide | Descriptor: | CALCIUM ION, CHLORIDE ION, Calpain-1 catalytic subunit, ... | Authors: | Qian, J, Campbell, R.L, Davies, P.L. | Deposit date: | 2007-09-12 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions. J.Med.Chem., 51, 2008
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