1ME1
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![BU of 1me1 by Molmil](/molmil-images/mine/1me1) | Chimeric hairpin with 2',5'-linked RNA loop and RNA stem | Descriptor: | 5'-R(*GP*GP*AP*CP*(U25)P*(U25)P*(C25)P*(5GP)P*GP*UP*CP*C)-3' | Authors: | Denisov, A.Y, Hannoush, R.N, Gehring, K, Damha, M.J. | Deposit date: | 2002-08-07 | Release date: | 2003-08-19 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A Novel RNA Motif Based on the Structure of Unusually Stable 2',5'-Linked r(UUCG) Loops J.AM.CHEM.SOC., 125, 2003
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7ZYX
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![BU of 7zyx by Molmil](/molmil-images/mine/7zyx) | |
8QDU
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![BU of 8qdu by Molmil](/molmil-images/mine/8qdu) | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions | Descriptor: | DNA (5'-D(*(FC)P*GP*(FC)P*GP*(FC)P*G)-3') | Authors: | El-Khoury, R, Cabrero, C, Movilla, S, Thorpe, J.D, Roman, M, Orozco, M, Gonzalez, C, Damha, M.J. | Deposit date: | 2023-08-30 | Release date: | 2024-06-26 | Last modified: | 2024-07-31 | Method: | SOLUTION NMR | Cite: | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions. Nucleic Acids Res., 52, 2024
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1ME0
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![BU of 1me0 by Molmil](/molmil-images/mine/1me0) | Chimeric hairpin with 2',5'-linked RNA loop and DNA stem | Descriptor: | DNA/RNA (5'-D(*GP*GP*AP*C)-R(P*(U25)P*(U25)P*(C25)P*(5GP))-D(P*GP*TP*CP*C)-3') | Authors: | Denisov, A.Y, Hannoush, R.N, Gehring, K, Damha, M.J. | Deposit date: | 2002-08-07 | Release date: | 2003-08-19 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A Novel RNA Motif Based on the Structure of Unusually Stable 2',5'-Linked r(UUCG) Loops J.AM.CHEM.SOC., 125, 2003
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5W5I
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![BU of 5w5i by Molmil](/molmil-images/mine/5w5i) | Human IFIT1 dimer with PPP-AAAA | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(ATP))-R(P*AP*AP*A)-3') | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2017-06-15 | Release date: | 2017-06-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding To Be Published
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5W5H
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![BU of 5w5h by Molmil](/molmil-images/mine/5w5h) | Human IFIT1 dimer with m7Gppp-AAAA | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3') | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2017-06-15 | Release date: | 2017-07-19 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding To Be Published
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4PEH
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![BU of 4peh by Molmil](/molmil-images/mine/4peh) | Dbr1 in complex with synthetic linear RNA | Descriptor: | GLYCEROL, MANGANESE (II) ION, RNA (5'-R(*CP*UP*AP*(A2P)P*AP*CP*AP*A)-3'), ... | Authors: | Montemayor, E.J, Katolik, A, Clark, N.E, Taylor, A.B, Schuermann, J.P, Combs, D.J, Johnsson, R, Holloway, S.P, Stevens, S.W, Damha, M.J, Hart, P.J. | Deposit date: | 2014-04-23 | Release date: | 2014-08-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Res., 42, 2014
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4PEI
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![BU of 4pei by Molmil](/molmil-images/mine/4pei) | Dbr1 in complex with synthetic branched RNA analog | Descriptor: | GLYCEROL, NICKEL (II) ION, RNA (5'-R(*(G46)P*U)-3'), ... | Authors: | Montemayor, E.J, Katolik, A, Clark, N.E, Taylor, A.B, Schuermann, J.P, Combs, D.J, Johnsson, R, Holloway, S.P, Stevens, S.W, Damha, M.J, Hart, P.J. | Deposit date: | 2014-04-23 | Release date: | 2014-08-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Res., 42, 2014
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4PEG
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![BU of 4peg by Molmil](/molmil-images/mine/4peg) | Dbr1 in complex with guanosine-5'-monophosphate | Descriptor: | GLYCEROL, GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Montemayor, E.J, Katolik, A, Clark, N.E, Taylor, A.B, Schuermann, J.P, Combs, D.J, Johnsson, R, Holloway, S.P, Stevens, S.W, Damha, M.J, Hart, P.J. | Deposit date: | 2014-04-23 | Release date: | 2014-08-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Res., 42, 2014
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4PEF
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![BU of 4pef by Molmil](/molmil-images/mine/4pef) | Dbr1 in complex with sulfate | Descriptor: | GLYCEROL, MANGANESE (II) ION, RNA lariat debranching enzyme, ... | Authors: | Montemayor, E.J, Katolik, A, Clark, N.E, Taylor, A.B, Schuermann, J.P, Combs, D.J, Johnsson, R, Holloway, S.P, Stevens, S.W, Damha, M.J, Hart, P.J. | Deposit date: | 2014-04-23 | Release date: | 2014-08-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Res., 42, 2014
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5MJX
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![BU of 5mjx by Molmil](/molmil-images/mine/5mjx) | 2'F-ANA/DNA Chimeric TBA Quadruplex structure | Descriptor: | DNA (5'-D(*GP*GP*(FT)P*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3') | Authors: | Lietard, J, Abou Assi, H, Gomez-Pinto, I, Gonzalez, C, Somoza, M.M, Damha, M.J. | Deposit date: | 2016-12-02 | Release date: | 2017-02-01 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Mapping the affinity landscape of Thrombin-binding aptamers on 2 F-ANA/DNA chimeric G-Quadruplex microarrays. Nucleic Acids Res., 45, 2017
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5UDK
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![BU of 5udk by Molmil](/molmil-images/mine/5udk) | IFIT1 monomeric mutant (L457E/L464E) with PPP-AAAA | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2016-12-27 | Release date: | 2017-03-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UDL
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![BU of 5udl by Molmil](/molmil-images/mine/5udl) | IFIT1 N216A monomeric mutant (L457E/L464E) with m7Gppp-AAAA (anti conformation of cap) | Descriptor: | CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3'), ... | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2016-12-27 | Release date: | 2017-03-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UDI
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![BU of 5udi by Molmil](/molmil-images/mine/5udi) | IFIT1 monomeric mutant (L457E/L464E) with m7Gppp-AAAA (syn and anti conformations of cap) | Descriptor: | CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3'), ... | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2016-12-27 | Release date: | 2017-03-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UDJ
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![BU of 5udj by Molmil](/molmil-images/mine/5udj) | IFIT1 monomeric mutant (L457E/L464E) with Gppp-AAAA | Descriptor: | CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(G3A))-R(P*AP*AP*A)-3'), ... | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2016-12-27 | Release date: | 2017-03-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2M1G
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![BU of 2m1g by Molmil](/molmil-images/mine/2m1g) | Parallel human telomeric quadruplex containing 2'F-ANA substitutions | Descriptor: | 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*(GFL)P*GP*GP*T)-3' | Authors: | Martin-Pintado, N, Yahyaee-Anzahaee, M, Deleavey, G.F, Portella, G, Orozco, M, Damha, M.J, Gonzalez, C. | Deposit date: | 2012-11-27 | Release date: | 2013-05-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Dramatic effect of furanose c2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom. J.Am.Chem.Soc., 135, 2013
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2N89
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![BU of 2n89 by Molmil](/molmil-images/mine/2n89) | Tetrameric i-motif structure of dT-dC-dC-CFL-CFL-dC at acidic pH | Descriptor: | DNA (5'-D(*TP*CP*CP*(CFL)P*(CFL)P*C)-3') | Authors: | Abou-Assi, H, Harkness, R.W, Martin-Pintado, N, Wilds, C.J, Campos-Olivas, R, Mittermaier, A.K, Gonzalez, C, Damha, M.J. | Deposit date: | 2015-10-09 | Release date: | 2016-08-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Stabilization of i-motif structures by 2'-beta-fluorination of DNA. Nucleic Acids Res., 44, 2016
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5VR4
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![BU of 5vr4 by Molmil](/molmil-images/mine/5vr4) | RNA octamer containing 2'-F-4'-OMe U. | Descriptor: | COBALT TETRAAMMINE ION, RNA (5'-R(*CP*GP*AP*AP*(UMO)P*UP*CP*G)-3') | Authors: | Harp, J.M, Egli, M. | Deposit date: | 2017-05-10 | Release date: | 2017-10-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | 4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing. J. Am. Chem. Soc., 139, 2017
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8QE4
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![BU of 8qe4 by Molmil](/molmil-images/mine/8qe4) | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions | Descriptor: | DNA (5'-D(*CP*(FRG)P*CP*(FRG)P*CP*(FRG))-3') | Authors: | El-Khoury, R, Cabrero, C, Movilla, S, Friedland, D, Thorpe, J.D, Roman, M, Orozco, M, Gonzalez, C, Damha, M. | Deposit date: | 2023-08-30 | Release date: | 2024-06-26 | Last modified: | 2024-07-31 | Method: | SOLUTION NMR | Cite: | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions. Nucleic Acids Res., 52, 2024
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8QOR
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![BU of 8qor by Molmil](/molmil-images/mine/8qor) | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions | Descriptor: | DNA (5'-D(*(CFL)P*(FRG)P*(CFL)P*(FRG)P*(CFL)P*(FRG))-3') | Authors: | El-Khoury, R, Cabrero, C, Movilla, S, Friedland, D, Thorpe, J.D, Roman, M, Orozco, M, Gonzalez, C, Damha, M. | Deposit date: | 2023-09-29 | Release date: | 2024-06-26 | Last modified: | 2024-07-31 | Method: | SOLUTION NMR | Cite: | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions. Nucleic Acids Res., 52, 2024
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1HO6
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![BU of 1ho6 by Molmil](/molmil-images/mine/1ho6) | |
1HOQ
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![BU of 1hoq by Molmil](/molmil-images/mine/1hoq) | CHIMERIC RNA/DNA HAIRPIN | Descriptor: | DNA/RNA (5'-R(*GP*GP*AP*C)-D(P*TP*TP*CP*GP*GP*TP*CP*C)-3') | Authors: | Denisov, A.Y, Gehring, K. | Deposit date: | 2000-12-11 | Release date: | 2001-11-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'-fluoro-ANA/RNA and DNA/RNA hybrids. Nucleic Acids Res., 29, 2001
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2LSC
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![BU of 2lsc by Molmil](/molmil-images/mine/2lsc) | Solution structure of 2'F-ANA and ANA self-complementary duplex | Descriptor: | DNA (5'-D(*(CFL)P*(GFL)P*(CFL)P*(GFL)P*(A5O)P*(A5O)P*(UAR)P*(UAR)P*(CFL)P*(GFL)P*(CFL)P*(GFL))-3') | Authors: | Martin-Pintado, N, Yahyaee, M, Campos, R, Noronha, A, Wilds, C, Damha, M, Gonzalez, C. | Deposit date: | 2012-04-26 | Release date: | 2012-07-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The solution structure of double helical arabino nucleic acids (ANA and 2'F-ANA): effect of arabinoses in duplex-hairpin interconversion. Nucleic Acids Res., 40, 2012
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2M8A
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![BU of 2m8a by Molmil](/molmil-images/mine/2m8a) | 2'F-ANA/2'F-RNA alternated sequences | Descriptor: | 2'F-RNA/2'F-ANA chimeric duplex | Authors: | Martin-Pintado, N, Deleavey, G, Portella, G, Campos, R, Orozco, M, Damha, M, Gonzalez, C. | Deposit date: | 2013-05-14 | Release date: | 2013-11-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Backbone FCHO Hydrogen Bonds in 2'F-Substituted Nucleic Acids. Angew.Chem.Int.Ed.Engl., 52, 2013
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2M84
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![BU of 2m84 by Molmil](/molmil-images/mine/2m84) | Structure of 2'F-RNA/2'F-ANA chimeric duplex | Descriptor: | 2'F-RNA/2'F-ANA CHIMERIC DUPLEX | Authors: | Martin-Pintado, N, Deleavey, G, Portella, G, Campos, R, Orozco, M, Damha, M, Gonzalez, C. | Deposit date: | 2013-05-07 | Release date: | 2013-11-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Backbone FCHO Hydrogen Bonds in 2'F-Substituted Nucleic Acids. Angew.Chem.Int.Ed.Engl., 52, 2013
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