5UDJ

IFIT1 monomeric mutant (L457E/L464E) with Gppp-AAAA

Summary for 5UDJ

• Entry DOI: 10.2210/pdb5udj/pdb
• Related: 5UDI 5UDK 5UDL
• Descriptor: Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(G3A))-R(P*AP*AP*A)-3'), TRIETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: mrna cap, guanosine-triphosphate rna, tetratricopeptide repeat, rna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 57491.71

Authors

Abbas, Y.M.,Martinez-Montero, S.,Damha, M.J.,Nagar, B. (deposition date: 2016-12-27, release date: 2017-03-01, Last modification date: 2024-03-06)

• Primary citation: Abbas, Y.M.,Laudenbach, B.T.,Martinez-Montero, S.,Cencic, R.,Habjan, M.,Pichlmair, A.,Damha, M.J.,Pelletier, J.,Nagar, B.; Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.; Proc. Natl. Acad. Sci. U.S.A., 114:E2106-E2115, 2017; PubMed: 28251928; DOI: 10.1073/pnas.1612444114

Experimental method

X-RAY DIFFRACTION (1.69 Å)