6WDT
 
 | | Enterovirus D68 in complex with human monoclonal antibody EV68-228 | | Descriptor: | EV68-228 heavy chain, EV68-228 light chain, viral protein 1, ... | | Authors: | Fu, J, Vogt, M.R, Klose, T, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2020-04-01 | | Release date: | 2020-07-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
Sci Immunol, 5, 2020
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7MKM
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7MKL
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6XO4
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6XOB
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5KEL
 | | EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ebola surface glycoprotein, ... | | Authors: | Pallesen, J, Murin, C.D, de Val, N, Cottrell, C.A, Hastie, K.M, Turner, H.L, Fusco, M.L, Flyak, A.I, Zeitlin, L, Crowe Jr, J.E, Andersen, K.G, Saphire, E.O, Ward, A.B. | | Deposit date: | 2016-06-09 | | Release date: | 2016-09-07 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
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5KEN
 | | EBOV GP in complex with variable Fab domains of IgGs c4G7 and c13C6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ebola surface glycoprotein, ... | | Authors: | Pallesen, J, Murin, C.D, de Val, N, Cottrell, C.A, Hastie, K.M, Turner, H.L, Fusco, M.L, Flyak, A.I, Zeitlin, L, Crowe Jr, J.E, Andersen, K.G, Saphire, E.O, Ward, A.B. | | Deposit date: | 2016-06-09 | | Release date: | 2016-09-07 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
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6DLB
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6DLA
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7M8L
 | | EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Virion spike glycoprotein 1, ... | | Authors: | Murin, C.D, Ward, A.B. | | Deposit date: | 2021-03-30 | | Release date: | 2021-11-10 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Pan-ebolavirus protective therapy by two multifunctional human antibodies.
Cell, 184, 2021
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8AHN
 | | Sin Nombre virus Gn in complex with Fab SNV-42 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, ... | | Authors: | Stass, R, Bowden, T.A. | | Deposit date: | 2022-07-22 | | Release date: | 2023-05-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody.
Nat Microbiol, 8, 2023
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8AWL
 | | Fab RVFV-268 | | Descriptor: | CITRIC ACID, Heavy chain Fab268, Light chain Fab268 | | Authors: | Hulswit, R.J.G, Bowden, T.A, Stass, R. | | Deposit date: | 2022-08-30 | | Release date: | 2023-09-06 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses.
Nat Commun, 14, 2023
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8AWM
 | | RVFV GnH with Fab268 bound | | Descriptor: | Glycoprotein, Heavy chain Fab268, Light chain Fab268 | | Authors: | Hulswit, R.J.G, Bowden, T.A, Stass, R. | | Deposit date: | 2022-08-30 | | Release date: | 2023-09-06 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses.
Nat Commun, 14, 2023
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7DWT
 | | Cryo-EM structure of Dengue virus serotype 1 strain WestPac 74 in complex with human antibody 1C19 Fab at 37 deg C (Class 1 particle) | | Descriptor: | Anti-dengue virus human monoclonal antibody 1C19 Fab heavy chain, Anti-dengue virus human monoclonal antibody 1C19 Fab light chain, envelope protein | | Authors: | Fibriansah, G, Ng, T.S, Kostyuchenko, V.A, Shi, J, Lok, S.M. | | Deposit date: | 2021-01-18 | | Release date: | 2021-02-17 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (19 Å) | | Cite: | Antibody affinity versus dengue morphology influences neutralization.
Plos Pathog., 17, 2021
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7DWU
 | | Cryo-EM structure of Dengue virus serotype 1 strain WestPac 74 in complex with human antibody 1C19 Fab at 37 deg C (Class 2 particle) | | Descriptor: | Anti-dengue virus human monoclonal antibody 1C19 Fab heavy chain, Anti-dengue virus human monoclonal antibody 1C19 Fab light chain, envelope protein | | Authors: | Fibriansah, G, Ng, T.S, Kostyuchenko, V.A, Shi, J, Lok, S.M. | | Deposit date: | 2021-01-18 | | Release date: | 2021-02-17 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (19 Å) | | Cite: | Antibody affinity versus dengue morphology influences neutralization.
Plos Pathog., 17, 2021
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6WDS
 | | Enterovirus D68 in complex with human monoclonal antibody EV68-159 | | Descriptor: | EV68-159 heavy chain, EV68-159 light chain, viral protein 1, ... | | Authors: | Fu, J, Klose, T, Vogt, M.R, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2020-04-01 | | Release date: | 2020-07-15 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
Sci Immunol, 5, 2020
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6IDI
 | | Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 8.0. | | Descriptor: | Envelope protein, Fab 1H10 heavy chain (V-region), Fab 1H10 light chain (V-region), ... | | Authors: | Wirawan, M, Fibriansah, G, Ng, T.S, Zhang, Q, Kostyuchenko, V.A, Shi, J, Lok, S.M. | | Deposit date: | 2018-09-10 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (12 Å) | | Cite: | Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.
Structure, 27, 2019
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6IDK
 | | Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 5.0 (Class I particle) | | Descriptor: | Envelope protein, Fab 1H10 heavy chain (V-region), Fab 1H10 light chain (V-region), ... | | Authors: | Wirawan, M, Fibriansah, G, Ng, T.S, Zhang, Q, Kostyuchenko, V.A, Shi, J, Lok, S.M. | | Deposit date: | 2018-09-10 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (25 Å) | | Cite: | Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.
Structure, 27, 2019
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6IDL
 | | Cryo-EM structure of Immature Dengue virus serotype 3 in complex with human antibody 1H10 Fab at pH 5.0 (Class II particle) | | Descriptor: | Envelope protein, Fab 1H10 heavy chain (V-region), Fab 1H10 light chain (V-region), ... | | Authors: | Wirawan, M, Fibriansah, G, Ng, T.S, Zhang, Q, Kostyuchenko, V.A, Shi, J, Lok, S.M. | | Deposit date: | 2018-09-10 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (25 Å) | | Cite: | Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.
Structure, 27, 2019
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5KEM
 | | EBOV sGP in complex with variable Fab domains of IgGs c13C6 and BDBV91 | | Descriptor: | BDBV91 variable Fab domain heavy chain, BDBV91 variable Fab domain light chain, Ebola secreted glycoprotein, ... | | Authors: | Pallesen, J, Murin, C.D, de Val, N, Cottrell, C.A, Hastie, K.M, Turner, H.L, Fusco, M.L, Flyak, A.I, Zeitlin, L, Crowe Jr, J.E, Andersen, K.G, Saphire, E.O, Ward, A.B. | | Deposit date: | 2016-06-09 | | Release date: | 2016-09-07 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
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3J6T
 | | Cryo-EM structure of Dengue virus serotype 3 at 37 degrees C | | Descriptor: | envelope protein, membrane protein | | Authors: | Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M. | | Deposit date: | 2014-03-25 | | Release date: | 2015-03-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
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3J6S
 | | Cryo-EM structure of Dengue virus serotype 3 at 28 degrees C | | Descriptor: | envelope protein, membrane protein | | Authors: | Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M. | | Deposit date: | 2014-03-24 | | Release date: | 2015-03-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
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3J6U
 | | Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab | | Descriptor: | Fab 5J7 heavy chain, Fab 5J7 light chain, envelope protein, ... | | Authors: | Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M. | | Deposit date: | 2014-03-26 | | Release date: | 2015-03-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
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6DL8
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6E9I
 | | The crystal structure of bovine ultralong antibody BOV-4 | | Descriptor: | Bovine ultralong antibody BOV-4 heavy chain, Bovine ultralong antibody BOV-4 light chain | | Authors: | Dong, J, Crowe, J.E. | | Deposit date: | 2018-08-01 | | Release date: | 2019-05-01 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains.
Front Immunol, 10, 2019
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