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Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	CHLORIDE ION, Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-28
Release date:	2019-10-02
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

6PJA

Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-28
Release date:	2019-10-02
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

6PJ5

Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-27
Release date:	2019-10-02
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

6PJ9

Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-28
Release date:	2019-10-02
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

6PJ7

Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-28
Release date:	2019-10-02
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

6PJQ

Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-28
Release date:	2019-11-27
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

6PJ8

Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-28
Release date:	2019-10-02
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

6PJP

Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-28
Release date:	2019-10-02
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

6PJ4

Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor:	Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2019-06-27
Release date:	2019-10-02
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019

5F5B

Structure of E.Coli GlpG complexed with peptidic inhibitor Ac-VRMA-CHO
Descriptor:	Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde
Authors:	Urban, S, Cho, S, Dickey, S.W.
Deposit date:	2015-12-04
Release date:	2016-02-17
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016

5F5G

Structure of E.Coli GlpG Y205F mutant complexed with peptidic inhibitor Ac-RMA-CHO in the DMPC/CHAPSO bicelle
Descriptor:	ACE-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S, Dickey, S.W.
Deposit date:	2015-12-04
Release date:	2016-04-06
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016

5F5J

E.coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle
Descriptor:	Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde
Authors:	Urban, S, Cho, S, Dickey, S.
Deposit date:	2015-12-04
Release date:	2016-02-10
Last modified:	2016-02-17
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016

5F5D

Crystal structures and Inhibition kinetics reveal a two-state catalytic mechanism with drug design implications for rhomboid proteolysis
Descriptor:	Rhomboid protease GlpG
Authors:	Urban, S, Cho, S, Dickey, S.W.
Deposit date:	2015-12-04
Release date:	2016-02-24
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016

5F5K

E.Coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle
Descriptor:	Peptidic derivative of Gurken: ACE-ARG-LYS-VAL-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG
Authors:	Urban, S, Cho, S, Dickey, S.W.
Deposit date:	2015-12-04
Release date:	2016-02-10
Last modified:	2016-02-17
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016

3G8K

Crystal structure of murine natural killer cell receptor, Ly49L4
Descriptor:	Lectin-related NK cell receptor LY49L1
Authors:	Cho, S.
Deposit date:	2009-02-12
Release date:	2009-11-17
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis. Immunity, 31, 2009

3G8L

Crystal structure of murine natural killer cell receptor, Ly49L4
Descriptor:	Lectin-related NK cell receptor LY49L1
Authors:	Cho, S.
Deposit date:	2009-02-12
Release date:	2009-11-17
Last modified:	2021-10-20
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis. Immunity, 31, 2009

4Z1A

Structure of apo form KDO8PS from H.pylori
Descriptor:	2-dehydro-3-deoxyphosphooctonate aldolase
Authors:	Lee, B.J, Cho, S, Im, H, Yoon, H.J.
Deposit date:	2015-03-27
Release date:	2016-03-09
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS). Eur.J.Med.Chem., 108, 2016

4Z1D

Structure of PEP and zinc bound KDO8PS from H.pylori
Descriptor:	2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE, ZINC ION
Authors:	Lee, B.J, Cho, S, Im, H, Yoon, H.J.
Deposit date:	2015-03-27
Release date:	2016-03-09
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS). Eur.J.Med.Chem., 108, 2016

4Z1B

Structure of H204A mutant KDO8PS from H.pylori
Descriptor:	2-dehydro-3-deoxyphosphooctonate aldolase
Authors:	Lee, B.J, Cho, S, Im, H, Yoon, H.J.
Deposit date:	2015-03-27
Release date:	2016-03-09
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS). Eur.J.Med.Chem., 108, 2016

4Z1C

Structure of Cadmium bound KDO8PS from H.pylori
Descriptor:	2-dehydro-3-deoxyphosphooctonate aldolase, CADMIUM ION
Authors:	Lee, B.J, Cho, S, Im, H, Yoon, H.J.
Deposit date:	2015-03-27
Release date:	2016-03-09
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (1.93 Å)
Cite:	Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS). Eur.J.Med.Chem., 108, 2016

3CAD

Crystal structure of Natural Killer Cell Receptor, Ly49G
Descriptor:	Lectin-related NK cell receptor LY49G1
Authors:	Cho, S.
Deposit date:	2008-02-19
Release date:	2008-04-08
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Molecular Architecture of the Major Histocompatibility Complex Class I-binding Site of Ly49 Natural Killer Cell Receptors. J.Biol.Chem., 283, 2008

6VJ8

Crystal structure of GlpG in complex with peptide chloromethylketone inhibitor
Descriptor:	Peptide chloromethylketone inhibitor, Rhomboid family intramembrane serine protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2020-01-15
Release date:	2020-09-16
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020

6VJ9

Crystal structure of GlpG in complex with peptide boronate inhibitor
Descriptor:	ACE-VAL-ARG-MET-B2A, Rhomboid family intramembrane serine protease GlpG
Authors:	Urban, S, Cho, S.
Deposit date:	2020-01-15
Release date:	2020-09-16
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020

6XRP

Crystal structure of GlpG in complex with peptide ketoamide inhibitor, Ac-RVWHA-ketoamide-phenylbutyl
Descriptor:	N-(4-phenylbutyl)formamide, Rhomboid protease GlpG, peptide ketoamide inhibitor
Authors:	Urban, S, Cho, S.
Deposit date:	2020-07-13
Release date:	2020-09-16
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020

6XRO

Crystal structure of GlpG in complex with peptide boronate inhibitor, Ac-KRFRSMQYSA-B(OH)2
Descriptor:	CHLORIDE ION, Rhomboid protease GlpG, SODIUM ION, ...
Authors:	Urban, S, Cho, S.
Deposit date:	2020-07-13
Release date:	2020-09-16
Last modified:	2024-04-24
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020

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