5F5K

E.Coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle

Summary for 5F5K

Entry DOI	10.2210/pdb5f5k/pdb
Related	5F5B 5F5D 5F5G 5F5J
Descriptor	Rhomboid protease GlpG, Peptidic derivative of Gurken: ACE-ARG-LYS-VAL-ARG-MET-ALA-aldehyde (3 entities in total)
Functional Keywords	glpg, rhomboid, intramembrane protease, bicelle, aldehyde inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli More
Cellular location	Cell inner membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein : A0A0J2E248
Total number of polymer chains	2
Total formula weight	24573.16
Authors	Urban, S.,Cho, S.,Dickey, S.W. (deposition date: 2015-12-04, release date: 2016-02-10, Last modification date: 2016-02-17)
Primary citation	Cho, S.,Dickey, S.W.,Urban, S. Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61:329-340, 2016 Cited by PubMed: 26805573 DOI: 10.1016/j.molcel.2015.12.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation