1ZW9
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6OLX
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![BU of 6olx by Molmil](/molmil-images/mine/6olx) | Hsp90-alpha S52A bound to PU-11-trans | Descriptor: | 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-alpha | Authors: | Gewirth, D.T, Huck, J.D. | Deposit date: | 2019-04-17 | Release date: | 2019-07-03 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.43760586 Å) | Cite: | Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins, 87, 2019
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3O2F
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3O0I
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6N8X
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![BU of 6n8x by Molmil](/molmil-images/mine/6n8x) | Hsp90-alpha bound to PU-11-trans | Descriptor: | 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-alpha | Authors: | Huck, J.D, Que, N.L.S, Gewirth, D.T. | Deposit date: | 2018-11-30 | Release date: | 2019-07-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.49484479 Å) | Cite: | Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins, 87, 2019
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6N8W
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6N8Y
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![BU of 6n8y by Molmil](/molmil-images/mine/6n8y) | Hsp90-beta bound to PU-11-trans | Descriptor: | 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-beta | Authors: | Huck, J.D, Que, N.L.S, Gewirth, D.T. | Deposit date: | 2018-11-30 | Release date: | 2019-07-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.553908 Å) | Cite: | Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins, 87, 2019
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6D1X
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![BU of 6d1x by Molmil](/molmil-images/mine/6d1x) | N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine | Descriptor: | Endoplasmin, N-PROPYL CARBOXYAMIDO ADENOSINE, TETRAETHYLENE GLYCOL | Authors: | Gewirth, D.T, Immormino, R.M. | Deposit date: | 2018-04-12 | Release date: | 2018-05-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90. J.Biol.Chem., 294, 2019
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6CYG
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![BU of 6cyg by Molmil](/molmil-images/mine/6cyg) | Hsp90-alpha N-domain bound to NEOCA | Descriptor: | 5'-N-(2-HYDROXYL)ETHYL CARBOXYAMIDO ADENOSINE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | Authors: | Huck, J.D, Campomizzi, C, Gewirth, D.T. | Deposit date: | 2018-04-05 | Release date: | 2019-04-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.503922 Å) | Cite: | NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90. J.Biol.Chem., 294, 2019
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6CYH
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![BU of 6cyh by Molmil](/molmil-images/mine/6cyh) | Hsp90-alpha N-domain bound to NEACA | Descriptor: | 5'-N-[(2-AMINO)ETHYL CARBOXAMIDO] ADENOSINE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | Authors: | Huck, J.D, Campomizzi, C, Gewirth, D.T. | Deposit date: | 2018-04-05 | Release date: | 2019-04-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90. J.Biol.Chem., 294, 2019
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6CYI
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![BU of 6cyi by Molmil](/molmil-images/mine/6cyi) | Grp94 N-domain bound to NEOCA | Descriptor: | 5'-N-(2-HYDROXYL)ETHYL CARBOXYAMIDO ADENOSINE, Endoplasmin, TETRAETHYLENE GLYCOL, ... | Authors: | Huck, J.D, Aw, W.J, Gewirth, D.T. | Deposit date: | 2018-04-05 | Release date: | 2019-04-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.7565825 Å) | Cite: | NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90. J.Biol.Chem., 294, 2019
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2FWZ
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2FWY
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2H55
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![BU of 2h55 by Molmil](/molmil-images/mine/2h55) | |