6CYG
Hsp90-alpha N-domain bound to NEOCA
Summary for 6CYG
Entry DOI | 10.2210/pdb6cyg/pdb |
Descriptor | Heat shock protein HSP 90-alpha, 5'-N-(2-HYDROXYL)ETHYL CARBOXYAMIDO ADENOSINE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | hsp90, inhibitor, chaperone, chaperone-inhibitor complex, chaperone/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 57919.19 |
Authors | Huck, J.D.,Campomizzi, C.,Gewirth, D.T. (deposition date: 2018-04-05, release date: 2019-04-10, Last modification date: 2023-10-04) |
Primary citation | Huck, J.D.,Que, N.L.S.,Immormino, R.M.,Shrestha, L.,Taldone, T.,Chiosis, G.,Gewirth, D.T. NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90. J.Biol.Chem., 294:16010-16019, 2019 Cited by PubMed: 31501246DOI: 10.1074/jbc.RA119.009960 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.50392199595 Å) |
Structure validation
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