2LZ3
 
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2LZ4
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3DSH
 | | Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain | | 分子名称: | Interferon regulatory factor 5 | | 著者 | Chen, W, Lam, S.S, Srinath, H, Jiang, Z, Correia, J.J, Schiffer, C, Fitzgerald, K.A, Lin, K, Royer Jr, W.E. | | 登録日 | 2008-07-12 | | 公開日 | 2008-10-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Nat.Struct.Mol.Biol., 15, 2008
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5HZQ
 | | Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate | | 分子名称: | 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, Cellular retinoic acid-binding protein 2, GLYCEROL | | 著者 | Chen, W, Mortenson, D.E, Wilson, I.A, Kelly, J.W. | | 登録日 | 2016-02-02 | | 公開日 | 2016-06-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
J.Am.Chem.Soc., 138, 2016
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3GBL
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8P8X
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7WJN
 | | CryoEM structure of chitin synthase 1 mutant E495A from Phytophthora sojae complexed with UDP-GlcNAc | | 分子名称: | Chitin synthase, MANGANESE (II) ION, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | | 著者 | Chen, W, Cao, P, Gong, Y, Yang, Q. | | 登録日 | 2022-01-07 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for directional chitin biosynthesis.
Nature, 610, 2022
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7X05
 | | CryoEM structure of chitin synthase 1 from Phytophthora sojae complexed with the nascent chitooligosaccharide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitin synthase, MANGANESE (II) ION, ... | | 著者 | Chen, W, Cao, P, Gong, Y, Yang, Q. | | 登録日 | 2022-02-21 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis for directional chitin biosynthesis.
Nature, 610, 2022
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7WJO
 | | CryoEM structure of chitin synthase 1 from Phytophthora sojae complexed with nikkomycin Z | | 分子名称: | (2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name), Chitin synthase | | 著者 | Chen, W, Cao, P, Gong, Y, Yang, Q. | | 登録日 | 2022-01-07 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for directional chitin biosynthesis.
Nature, 610, 2022
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7X06
 | | CryoEM structure of chitin synthase 1 from Phytophthora sojae complexed with UDP | | 分子名称: | Chitin synthase, MAGNESIUM ION, URIDINE-5'-DIPHOSPHATE | | 著者 | Chen, W, Cao, P, Gong, Y, Yang, Q. | | 登録日 | 2022-02-21 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for directional chitin biosynthesis.
Nature, 610, 2022
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7WJM
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5Y2B
 | | Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with HEPTA-N-ACETYLCHITOOCTAOSE (NAG)7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, insect group II chitinase | | 著者 | Chen, W, Qu, M.B, Zhou, Y, Yang, Q. | | 登録日 | 2017-07-24 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
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5Y2C
 | | Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 2 E2180L mutant in complex with PENTA-N-ACETYLCHITOOCTAOSE (NAG)5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, insect group II chitinase | | 著者 | Chen, W, Qu, M.B, Zhou, Y, Yang, Q. | | 登録日 | 2017-07-24 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
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5Y2A
 | | Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 2 | | 分子名称: | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, insect group II chitinase | | 著者 | Chen, W, Qu, M.B, Zhou, Y, Yang, Q. | | 登録日 | 2017-07-24 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
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5Y29
 | | Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, insect group II chitinase | | 著者 | Chen, W, Qu, M.B, Zhou, Y, Yang, Q. | | 登録日 | 2017-07-24 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
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6JAW
 | | Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with a napthalimide derivative | | 分子名称: | 2-[3-(morpholin-4-yl)propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, Group II chitinase | | 著者 | Chen, W, Zhou, Y, Yang, Q. | | 登録日 | 2019-01-25 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.981 Å) | | 主引用文献 | Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
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6JAV
 | | Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with a piperidine-thienopyridine derivative | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-chlorophenyl)methyl]sulfanyl}-7-methyl-N-(prop-2-en-1-yl)-7,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine, Group II chitinase | | 著者 | Chen, W, Zhou, Y, Yang, Q. | | 登録日 | 2019-01-25 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.437 Å) | | 主引用文献 | Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
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6JAY
 | | Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with a dipyrido-pyrimidine derivative | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-1-[(furan-2-yl)methyl]-5-oxo-3-({[(2S)-oxolan-2-yl]methyl}carbamoyl)-5H-dipyrido[1,2-a:2',3'-d]pyrimidin-1-ium, Group II chitinase | | 著者 | Chen, W, Zhou, Y, Yang, Q. | | 登録日 | 2019-01-25 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.498 Å) | | 主引用文献 | Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
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6JAX
 | | Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with chitooctaose [(GlcN)8] | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, Group II chitinase | | 著者 | Chen, W, Zhou, Y, Yang, Q. | | 登録日 | 2019-01-25 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
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6K3Z
 | | Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM) | | 分子名称: | CRISPR-associated endonuclease Cas9, DNA (28-MER), DNA (5'-D(*AP*AP*AP*TP*GP*AP*TP*AP*TP*TP*G)-3'), ... | | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | 登録日 | 2019-05-22 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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6K4P
 | | Crystal structure of xCas9 in complex with sgRNA and DNA (TGG PAM) | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), PHOSPHATE ION, ... | | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | 登録日 | 2019-05-25 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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6K4U
 | | Crystal structure of xCas9 in complex with sgRNA and DNA (TGA PAM) | | 分子名称: | CRISPR-associated endonuclease Cas9, non-target DNA, sgRNA, ... | | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | 登録日 | 2019-05-27 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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6K4S
 | | Crystal structure of xCas9 in complex with sgRNA and DNA (TGC PAM) | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, non-targeted DNA, sgRNA, ... | | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | 登録日 | 2019-05-26 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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6K57
 | | Crystal structure of dCas9 in complex with sgRNA and DNA (CGA PAM) | | 分子名称: | CRISPR-associated endonuclease Cas9, non-target DNA, sgRNA, ... | | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | 登録日 | 2019-05-28 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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6K4Q
 | | Crystal structure of xCas9 in complex with sgRNA and DNA (CGG PAM) | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), DNA (5'-D(*AP*AP*AP*CP*GP*GP*TP*AP*TP*TP*G)-3'), ... | | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | 登録日 | 2019-05-26 | | 公開日 | 2019-09-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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