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2NY5
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HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) Complexed with CD4 and Antibody 17b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ...
Authors:Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D.
Deposit date:2006-11-20
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature, 445, 2007
2NXZ
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BU of 2nxz by Molmil
HIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody 17b
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, ...
Authors:Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D.
Deposit date:2006-11-20
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature, 445, 2007
2NY1
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BU of 2ny1 by Molmil
HIV-1 gp120 Envelope Glycoprotein (I109C, T257S, S334A, S375W, Q428C) Complexed with CD4 and Antibody 17b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ...
Authors:Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D.
Deposit date:2006-11-20
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature, 445, 2007
3MUG
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BU of 3mug by Molmil
Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody PG16 Heavy Chain, ...
Authors:Pejchal, R, Walker, L.M, Burton, D.R, Wilson, I.A.
Deposit date:2010-05-03
Release date:2010-06-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MUH
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BU of 3muh by Molmil
Crystal structure of PG9 light chain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody PG9 light chain
Authors:Pejchal, R, Walker, L.M, Burton, D.R, Wilson, I.A.
Deposit date:2010-05-03
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OAZ
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BU of 3oaz by Molmil
A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity
Descriptor: CHLORIDE ION, Fab 2G12, heavy chain, ...
Authors:Doores, K.J, Fulton, Z, Hong, V, Patel, M.K, Scanlan, C.N, Wormald, M.R, Finn, M.G, Burton, D.R, Wilson, I.A, Davis, B.G.
Deposit date:2010-08-06
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OAY
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BU of 3oay by Molmil
A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity
Descriptor: Fab 2G12, heavy chain, light chain, ...
Authors:Doores, K.J, Fulton, Z, Hong, V, Patel, M.K, Scanlan, C.N, Wormald, M.R, Finn, M.G, Burton, D.R, Wilson, I.A, Davis, B.G.
Deposit date:2010-08-05
Release date:2011-01-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OAU
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BU of 3oau by Molmil
Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Non-Domain-Exchanged Forms, but only binds the HIV-1 Glycan Shield if Domain-Exchanged
Descriptor: Fab 2G12, heavy chain, light chain, ...
Authors:Doores, K.J, Fulton, Z, Huber, M, Wilson, I.A, Burton, D.R.
Deposit date:2010-08-05
Release date:2011-01-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged.
J.Virol., 84, 2010
3OB0
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BU of 3ob0 by Molmil
A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity
Descriptor: 7-deoxy-L-glycero-alpha-D-manno-heptopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose, Fab 2G12, heavy chain, ...
Authors:Doores, K.J, Fulton, Z, Hong, V, Patel, M.K, Scanlan, C.N, Wormald, M.R, Finn, M.G, Burton, D.R, Wilson, I.A, Davis, B.G.
Deposit date:2010-08-06
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proc.Natl.Acad.Sci.USA, 107, 2010
4JY6
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BU of 4jy6 by Molmil
Crystal structure of human Fab PGT123, a broadly reactive and potent HIV-1 neutralizing antibody
Descriptor: GLYCEROL, PGT123 heavy chain, PGT123 light chain, ...
Authors:Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A.
Deposit date:2013-03-29
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans.
Plos Pathog., 9, 2013
4JY5
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BU of 4jy5 by Molmil
Crystal structure of human Fab PGT122, a broadly reactive and potent HIV-1 neutralizing antibody
Descriptor: GLYCEROL, PGT122 heavy chain, PGT122 light chain
Authors:Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A.
Deposit date:2013-03-29
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Plos Pathog., 9, 2013
4JY4
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BU of 4jy4 by Molmil
Crystal structure of human Fab PGT121, a broadly reactive and potent HIV-1 neutralizing antibody
Descriptor: GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PGT121 heavy chain, ...
Authors:Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A.
Deposit date:2013-03-29
Release date:2013-05-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Plos Pathog., 9, 2013
6OHY
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BU of 6ohy by Molmil
Chimpanzee SIV Env trimeric ectodomain.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pallesen, J, Andrabi, R, de Val, N, Burton, D.R, Ward, A.B.
Deposit date:2019-04-08
Release date:2019-06-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template.
Cell Rep, 27, 2019
7KCR
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BU of 7kcr by Molmil
Cryo-EM structure of Zika virus in complex with E protein cross-linking human monoclonal antibody ADI30056
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADI30056 Fab heavy chain variable region, ADI30056 Fab light chain variable region, ...
Authors:Sevvana, M, Rogers, T.F, Miller, A.S, Long, F, Klose, T, Beutler, N, Lai, Y.C, Parren, M, Walker, L.M, Buda, G, Burton, D.R, Rossmann, M.G, Kuhn, R.J.
Deposit date:2020-10-07
Release date:2020-12-16
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural Basis of Zika Virus Specific Neutralization in Subsequent Flavivirus Infections.
Viruses, 12, 2020
6XY4
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BU of 6xy4 by Molmil
Structural insight into sheep-pox virus mediated inhibition of apoptosis
Descriptor: Activator of apoptosis harakiri, anti-apoptotic membrane protein
Authors:Suraweera, C.D, Hinds, M.G, Kvansakul, M.
Deposit date:2020-01-29
Release date:2020-07-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.04623151 Å)
Cite:Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax.
Febs Lett., 594, 2020
6XY6
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BU of 6xy6 by Molmil
Structural insight into sheep-pox virus mediated inhibition of apoptosis
Descriptor: Apoptosis regulator BAX, anti-apoptotic membrane protein
Authors:Suraweera, C.D, Hinds, M.G, Kvansakul, M.
Deposit date:2020-01-29
Release date:2020-07-29
Method:X-RAY DIFFRACTION (2.91414642 Å)
Cite:Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax.
Febs Lett., 594, 2020
8DGV
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BU of 8dgv by Molmil
Crystal structure of MERS-CoV spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC99.103 isolated from a vaccinated COVID-19 convalescent
Descriptor: Antibody CC99.103 Fab heavy chain, Antibody CC99.103 Fab light chain, Spike protein S2'
Authors:Liu, H, Wilson, I.A.
Deposit date:2022-06-24
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Immunity, 56, 2023
8DGW
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Crystal structure of HCoV-HKU1 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC95.108 isolated from a vaccinated COVID-19 convalescent
Descriptor: Antibody CC95.108 Fab heavy chain, Antibody CC95.108 Fab light chain, Spike protein S2'
Authors:Liu, H, Wilson, I.A.
Deposit date:2022-06-24
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Immunity, 56, 2023
8DGU
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BU of 8dgu by Molmil
Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC25.106 isolated from a vaccinated COVID-19 convalescent
Descriptor: Antibody CC25.106 Fab heavy chain, Antibody CC25.106 Fab light chain, GLYCEROL, ...
Authors:Liu, H, Wilson, I.A.
Deposit date:2022-06-24
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Immunity, 56, 2023
8DGX
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BU of 8dgx by Molmil
Crystal structure of MERS-CoV spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC68.109 isolated from a vaccinated COVID-19 convalescent
Descriptor: Antibody CC68.109 Fab heavy chain, Antibody CC68.109 Fab light chain, Spike protein S2'
Authors:Liu, H, Wilson, I.A.
Deposit date:2022-06-24
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Immunity, 56, 2023
2HH0
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BU of 2hh0 by Molmil
Structure of an Anti-PrP Fab, P-Clone, in Complex with its Cognate Bovine Peptide Epitope.
Descriptor: Heavy Chain, P-Clone Fab, Chimera, ...
Authors:Kanyo, Z.K.
Deposit date:2006-06-27
Release date:2006-12-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation
J.Mol.Biol., 363, 2006
6BF4
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BU of 6bf4 by Molmil
Crystal Structure of HIV-1 Clade AE Strain CNE55 gp120 Core in Complex with Neutralizing Antibody VRC-PG05 that Targets the Center of the Silent Face on the Outer Domain of gp120
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2017-10-25
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.
Immunity, 48, 2018
4DGV
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BU of 4dgv by Molmil
Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody HCV1, P2(1) form
Descriptor: E2 peptide, HCV1 Heavy Chain, HCV1 Light Chain, ...
Authors:Kong, L, Wilson, I.A, Law, M.
Deposit date:2012-01-26
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.805 Å)
Cite:Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1.
Proc.Natl.Acad.Sci.USA, 109, 2012
4DGY
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BU of 4dgy by Molmil
Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody HCV1, C2 form
Descriptor: CHLORIDE ION, E2 peptide, GLYCEROL, ...
Authors:Kong, L, Wilson, I.A, Law, M.
Deposit date:2012-01-27
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1.
Proc.Natl.Acad.Sci.USA, 109, 2012
4DQO
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Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109
Descriptor: 1FD6-V1V2 scaffold ZM109 HIV-1 strain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG16 Fab Heavy Chain, ...
Authors:Pancera, M, McLellan, J.S, Kwong, P.D.
Deposit date:2012-02-16
Release date:2013-03-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.438 Å)
Cite:Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
Nat.Struct.Mol.Biol., 20, 2013

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