3MUG

Crystal structure of human Fab PG16, a broadly reactive and potent HIV-1 neutralizing antibody

Summary for 3MUG

• Entry DOI: 10.2210/pdb3mug/pdb
• Related: 3MUH
• Descriptor: Antibody PG16 Light Chain, Antibody PG16 Heavy Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: pg16, fab, sulfotyrosine, hiv, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 294886.45

Authors

Pejchal, R.,Walker, L.M.,Burton, D.R.,Wilson, I.A. (deposition date: 2010-05-03, release date: 2010-06-16, Last modification date: 2023-11-22)

• Primary citation: Pejchal, R.,Walker, L.M.,Stanfield, R.L.,Phogat, S.K.,Koff, W.C.,Poignard, P.,Burton, D.R.,Wilson, I.A.; Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.; Proc.Natl.Acad.Sci.USA, 107:11483-11488, 2010; PubMed: 20534513; DOI: 10.1073/pnas.1004600107

Experimental method

X-RAY DIFFRACTION (2.49 Å)