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6BF4

Crystal Structure of HIV-1 Clade AE Strain CNE55 gp120 Core in Complex with Neutralizing Antibody VRC-PG05 that Targets the Center of the Silent Face on the Outer Domain of gp120

Summary for 6BF4
Entry DOI10.2210/pdb6bf4/pdb
DescriptorHIV-1 clade AE gp120 core, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
Functional Keywordsantibody, hiv-1, silent face, glycan, gp120, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman immunodeficiency virus 1
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Total number of polymer chains6
Total formula weight188011.69
Authors
Zhou, T.,Kwong, P.D. (deposition date: 2017-10-25, release date: 2018-03-07, Last modification date: 2023-10-04)
Primary citationZhou, T.,Zheng, A.,Baxa, U.,Chuang, G.Y.,Georgiev, I.S.,Kong, R.,O'Dell, S.,Shahzad-Ul-Hussan, S.,Shen, C.H.,Tsybovsky, Y.,Bailer, R.T.,Gift, S.K.,Louder, M.K.,McKee, K.,Rawi, R.,Stevenson, C.H.,Stewart-Jones, G.B.E.,Taft, J.D.,Waltari, E.,Yang, Y.,Zhang, B.,Shivatare, S.S.,Shivatare, V.S.,Lee, C.D.,Wu, C.Y.,Mullikin, J.C.,Bewley, C.A.,Burton, D.R.,Polonis, V.R.,Shapiro, L.,Wong, C.H.,Mascola, J.R.,Kwong, P.D.,Wu, X.
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.
Immunity, 48:500-513.e6, 2018
Cited by
PubMed: 29548671
DOI: 10.1016/j.immuni.2018.02.013
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.382 Å)
Structure validation

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