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8OU0
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BU of 8ou0 by Molmil
bovine sperm endpiece singlet microtubules (one tubulin dimer and associated microtubule inner proteins)
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Leung, M.R, Zeev-Ben-Mordehai, T.
Deposit date:2023-04-21
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural specializations of the sperm tail.
Cell, 186, 2023
8OTZ
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BU of 8otz by Molmil
48-nm repeat of the native axonemal doublet microtubule from bovine sperm
Descriptor: ATP6V1F neighbor, CFAP97 domain containing 1, Chromosome 13 C20orf85 homolog, ...
Authors:Leung, M.R, Zeng, J, Zhang, R, Zeev-Ben-Mordehai, T.
Deposit date:2023-04-21
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural specializations of the sperm tail.
Cell, 186, 2023
7KZM
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BU of 7kzm by Molmil
Outer dynein arm bound to doublet microtubules from C. reinhardtii
Descriptor: DC1, DC2, Dynein 11 kDa light chain, ...
Authors:Walton, T, Wu, H, Brown, A.B.
Deposit date:2020-12-10
Release date:2021-01-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:Structure of a microtubule-bound axonemal dynein.
Nat Commun, 12, 2021
8OS5
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BU of 8os5 by Molmil
Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction
Descriptor: Coagulation factor XII-Mie
Authors:Li, C, Saleem, M, Kaira, B.G, Brown, A, Wilson, C, Philippou, H, Emsley, J.
Deposit date:2023-04-18
Release date:2024-03-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.
Blood, 136, 2020
6RW2
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BU of 6rw2 by Molmil
Bicycle Toxin Conjugate bound to EphA2
Descriptor: 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, ALA-ARG-ASP-CYS-PRO-LEU-VAL-ASN-PRO-LEU-CYS-LEU-HIS-PRO-GLY-TRP-THR-CYS, Ephrin type-A receptor 2, ...
Authors:Brown, D.G, Schroeder, S, Chen, L.
Deposit date:2019-06-03
Release date:2020-04-08
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads.
J.Med.Chem., 63, 2020
7KZO
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BU of 7kzo by Molmil
Outer dynein arm docking complex bound to doublet microtubules from C. reinhardtii
Descriptor: Dynein gamma chain, flagellar outer arm, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Walton, T, Wu, H, Brown, A.B.
Deposit date:2020-12-10
Release date:2021-01-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of a microtubule-bound axonemal dynein.
Nat Commun, 12, 2021
4EZK
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BU of 4ezk by Molmil
Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
Descriptor: 2-(1-{[2-(2H-indazol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Murray, J.M.
Deposit date:2012-05-02
Release date:2013-04-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012
4EZL
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BU of 4ezl by Molmil
Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
Descriptor: 2-(1-{[2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Murray, J.M.
Deposit date:2012-05-02
Release date:2013-04-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012
4EZJ
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BU of 4ezj by Molmil
Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
Descriptor: 2-(1-{[2-(5-fluoro-1H-indol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Murray, J.M.
Deposit date:2012-05-02
Release date:2013-04-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012
4J23
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BU of 4j23 by Molmil
Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex
Descriptor: Fibroblast growth factor 1, Fibroblast growth factor receptor 2
Authors:Kudlinzki, D, Saxena, K, Sreeramulu, S, Schieborr, U, Dreyer, M, Schreuder, H, Schwalbe, H.
Deposit date:2013-02-04
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.882 Å)
Cite:Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Cancer Cell, 23, 2013
7KZN
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BU of 7kzn by Molmil
Outer dynein arm core subcomplex from C. reinhardtii
Descriptor: DC1, DC2, Dynein 11 kDa light chain, ...
Authors:Walton, T, Wu, H, Brown, A.B.
Deposit date:2020-12-10
Release date:2021-01-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of a microtubule-bound axonemal dynein.
Nat Commun, 12, 2021
3JAS
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BU of 3jas by Molmil
Cryo-EM structure of dynamic GDP-microtubule (14 protofilaments) decorated with kinesin
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zhang, R, Nogales, E.
Deposit date:2015-06-19
Release date:2015-08-12
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAT
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BU of 3jat by Molmil
Cryo-EM structure of GMPCPP-microtubule (14 protofilaments) decorated with kinesin
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Zhang, R, Nogales, E.
Deposit date:2015-06-20
Release date:2015-08-12
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAR
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BU of 3jar by Molmil
Cryo-EM structure of GDP-microtubule co-polymerized with EB3
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zhang, R, Nogales, E.
Deposit date:2015-06-19
Release date:2015-08-12
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAW
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BU of 3jaw by Molmil
Atomic model of a microtubule seam based on a cryo-EM reconstruction of the EB3-bound microtubule (merged dataset containing tubulin bound to GTPgammaS, GMPCPP, and GDP)
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zhang, R, Nogales, E.
Deposit date:2015-06-30
Release date:2015-08-12
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAL
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BU of 3jal by Molmil
Cryo-EM structure of GMPCPP-microtubule co-polymerized with EB3
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Microtubule-associated protein RP/EB family member 3, ...
Authors:Zhang, R, Nogales, E.
Deposit date:2015-06-16
Release date:2015-08-12
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAK
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BU of 3jak by Molmil
Cryo-EM structure of GTPgammaS-microtubule co-polymerized with EB3 (merged dataset with and without kinesin bound)
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zhang, R, Nogales, E.
Deposit date:2015-06-16
Release date:2015-08-12
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
4HS6
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BU of 4hs6 by Molmil
Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody MRCT10.v362
Descriptor: E2-peptide, MRCT10.v362 Fab heavy chain, MRCT10.v362 Fab light chain
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2012-10-29
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Glycan shifting on hepatitis C virus (HCV) e2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.
J.Mol.Biol., 425, 2013
4HS8
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BU of 4hs8 by Molmil
Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody hu5B3.v3
Descriptor: E2-peptide, GLYCEROL, SULFATE ION, ...
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2012-10-29
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Glycan shifting on hepatitis C virus (HCV) e2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.
J.Mol.Biol., 425, 2013
4AHC
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BU of 4ahc by Molmil
Crystal Structure of an Evolved Replicating DNA Polymerase
Descriptor: DNA POLYMERASE, GLYCEROL
Authors:Wynne, S.A, Holliger, P, Leslie, A.G.W.
Deposit date:2012-02-06
Release date:2012-03-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of an Apo and a Binary Complex of an Evolved Archeal B Family DNA Polymerase Capable of Synthesising Highly Cy-Dye Labelled DNA.
Plos One, 8, 2013
4AIL
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BU of 4ail by Molmil
Crystal Structure of an Evolved Replicating DNA Polymerase
Descriptor: 5'-D(*AP*CP*GP*GP*GP*TP*AP*AP*GP*CP*AP)-3', 5'-D(*TP*GP*CP*TP*TP*AP*CP*DOCP)-3', DNA POLYMERASE
Authors:Wynne, S.A, Holliger, P, Leslie, A.G.W.
Deposit date:2012-02-10
Release date:2012-03-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of an Apo and a Binary Complex of an Evolved Archeal B Family DNA Polymerase Capable of Synthesising Highly Cy-Dye Labelled DNA.
Plos One, 8, 2013
3JBO
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BU of 3jbo by Molmil
Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ...
Authors:Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3JBP
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BU of 3jbp by Molmil
Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ...
Authors:Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3JBN
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BU of 3jbn by Molmil
Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ...
Authors:Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
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