3UD6
| Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design | 分子名称: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, RETRO-ALDOLASE, SULFATE ION | 著者 | Baker, D, Stoddard, B.L, Althoff, E.A, Wang, L, Jiang, L, Moody, J, Bolduc, J, Lassila, J, Hilvert, D. | 登録日 | 2011-10-27 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
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8VC8
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8T5E
| De novo design of high-affinity protein binders to bioactive helical peptides | 分子名称: | Bcl-2-like protein 11, Bim_fulldiff | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | 登録日 | 2023-06-13 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
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8T5F
| De novo design of high-affinity protein binders to bioactive helical peptides | 分子名称: | Parathyroid hormone | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | 登録日 | 2023-06-13 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
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8TCG
| Integrin alpha-v beta-6 in complex with minibinder B6_BP_dslf | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-V heavy chain, ... | 著者 | Campbell, M.G, Fernandez, A, Roy, A, Kraft, J, Baker, D. | 登録日 | 2023-06-30 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8. Nat Commun, 14, 2023
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8TCF
| Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Campbell, M.G, Fernandez, A, Roy, A, Kraft, J, Baker, D. | 登録日 | 2023-06-30 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8. Nat Commun, 14, 2023
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8UB3
| DpHF7 filament | 分子名称: | DpHF7 filament | 著者 | Lynch, E.M, Farrell, D, Shen, H, Kollman, J.M, DiMaio, F, Baker, D. | 登録日 | 2023-09-22 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | De novo design of pH-responsive self-assembling helical protein filaments. Nat Nanotechnol, 2024
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8UBG
| DpHF19 filament | 分子名称: | DpHF19,Green fluorescent protein (Fragment) | 著者 | Lynch, E.M, Shen, H, Kollman, J.M, Baker, D. | 登録日 | 2023-09-22 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | De novo design of pH-responsive self-assembling helical protein filaments. Nat Nanotechnol, 2024
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8UAO
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6O0I
| NMR ensemble of computationally designed protein XAA | 分子名称: | Design construct XAA | 著者 | Wei, K.Y, Moschidi, D, Nerli, S, Sgourakis, N, Baker, D. | 登録日 | 2019-02-16 | 公開日 | 2020-04-22 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. Proc.Natl.Acad.Sci.USA, 117, 2020
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6O0C
| NMR ensemble of computationally designed protein XAA_GVDQ mutant M4L | 分子名称: | Design construct XAA_GVDQ mutant M4L | 著者 | Wei, K.Y, Moschidi, D, Nerli, S, Sgourakis, N, Baker, D. | 登録日 | 2019-02-15 | 公開日 | 2020-04-22 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. Proc.Natl.Acad.Sci.USA, 117, 2020
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8G9J
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8G9K
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8GA6
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8GA7
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8UGC
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8U5A
| Improving protein expression, stability, and function with ProteinMPNN | 分子名称: | Designed myoglobin, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Kalvet, I, Bera, A.K, Baker, D. | 登録日 | 2023-09-12 | 公開日 | 2024-01-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Improving Protein Expression, Stability, and Function with ProteinMPNN. J.Am.Chem.Soc., 146, 2024
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8SKD
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8SKE
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8SKX
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8E1E
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8F4X
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8F54
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8F53
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8FIT
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