8CZH
| Human BAK in complex with the dM2 peptide | 分子名称: | Bcl-2 homologous antagonist/killer, DM2 peptide | 著者 | Aguilar, F, Keating, A.E. | 登録日 | 2022-05-24 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization. Structure, 31, 2023
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8CZG
| Human BAK in complex with the dF3 peptide | 分子名称: | Bcl-2 homologous antagonist/killer, dF3 peptide | 著者 | Aguilar, F, Keating, A.E. | 登録日 | 2022-05-24 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization. Structure, 31, 2023
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6OB1
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5L9U
| Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | 登録日 | 2016-06-11 | 公開日 | 2016-09-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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5L9T
| Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | 登録日 | 2016-06-11 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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6JDD
| Crystal structure of the cypemycin decarboxylase CypD. | 分子名称: | Cypemycin cysteine dehydrogenase (decarboxylating), DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Zhang, Q, Yuan, H. | 登録日 | 2019-02-01 | 公開日 | 2019-03-06 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis. FEBS Lett., 593, 2019
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4Z7P
| X-ray structure of racemic ShK Q16K toxin | 分子名称: | Potassium channel toxin kappa-stichotoxin-She1a, SULFATE ION | 著者 | Sickmier, E.A. | 登録日 | 2015-04-07 | 公開日 | 2015-09-09 | 最終更新日 | 2015-09-23 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. J.Med.Chem., 58, 2015
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8ITE
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8JE1
| An asymmetry dimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complexed with BEX2 | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | 著者 | Dai, Z, Liang, L, Yin, Y.X. | 登録日 | 2023-05-15 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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8JE2
| Cryo-EM structure of neddylated Cul2-Rbx1-EloBC-FEM1B complexed with FNIP1-FLCN | 分子名称: | Cullin-2, Elongin-B, Elongin-C, ... | 著者 | Dai, Z, Liang, L, Yin, Y.X. | 登録日 | 2023-05-15 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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6KK0
| Crystal structure of PDE4D catalytic domain complexed with compound 4e | 分子名称: | 7-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-9-yl]oxyheptanoic acid, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.20008755 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
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6NXL
| Ubiquitin binding variants | 分子名称: | Polyubiquitin-B | 著者 | Miller, D.J, Watson, E.R. | 登録日 | 2019-02-08 | 公開日 | 2020-01-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | 主引用文献 | Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc.Natl.Acad.Sci.USA, 116, 2019
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6NXK
| Ubiquitin binding variants | 分子名称: | Anaphase-promoting complex subunit 2, Polyubiquitin-C | 著者 | Miller, D.J, Watson, E.R. | 登録日 | 2019-02-08 | 公開日 | 2020-01-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc.Natl.Acad.Sci.USA, 116, 2019
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6KJZ
| Crystal structure of PDE4D catalytic domain complexed with compound 1 | 分子名称: | 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.200001 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
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8IJ1
| Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | 著者 | Dai, Z, Liang, L, Yin, Y.X. | 登録日 | 2023-02-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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5X5Y
| A membrane protein complex | 分子名称: | Probable ATP-binding component of ABC transporter, Uncharacterized protein | 著者 | Luo, Q, Yang, X, Huang, Y. | 登録日 | 2017-02-18 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.465 Å) | 主引用文献 | Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG Nat. Struct. Mol. Biol., 24, 2017
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5Z1W
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2GLX
| Crystal Structure Analysis of bacterial 1,5-AF Reductase | 分子名称: | 1,5-anhydro-D-fructose reductase, ACETATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Dambe, T.R, Scheidig, A.J. | 登録日 | 2006-04-05 | 公開日 | 2006-08-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of NADP(H)-Dependent 1,5-Anhydro-d-fructose Reductase from Sinorhizobium morelense at 2.2 A Resolution: Construction of a NADH-Accepting Mutant and Its Application in Rare Sugar Synthesis Biochemistry, 45, 2006
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7V4J
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7V4I
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7V4H
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7V4K
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7V4L
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