2OJL
| Crystal structure of Q7WAF1_BORPA from Bordetella parapertussis. Northeast Structural Genomics target BpR68. | 分子名称: | Hypothetical protein | 著者 | Benach, J, Neely, H, Seetharaman, J, Wang, H, Fang, Y, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-01-12 | 公開日 | 2007-01-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of Q7WAF1_BORPA from Bordetella parapertussis To be Published
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2OTA
| Crystal structure of the UPF0352 protein CPS_2611 from Colwellia psychrerythraea. NESG target CsR4. | 分子名称: | UPF0352 protein CPS_2611 | 著者 | Vorobiev, S.M, Zhou, W, Su, M, Seetharaman, J, Wang, H, Janjua, H, Cunningham, K, Ma, L.-C, Xiao, R, Liu, C, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-02-07 | 公開日 | 2007-02-20 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of the UPF0352 protein CPS_2611 from Colwellia psychrerythraea. NESG target CsR4. To be Published
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8BYQ
| RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W) | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Abril-Garrido, J, Dienemann, C, Grabbe, F, Velychko, T, Lidschreiber, M, Wang, H, Cramer, P. | 登録日 | 2022-12-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Mol.Cell, 83, 2023
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8BZ1
| RNA polymerase II core pre-initiation complex with the proximal +1 nucleosome (cPIC-Nuc10W) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | Abril-Garrido, J, Dienemann, C, Grabbe, F, Velychko, T, Lidschreiber, M, Wang, H, Cramer, P. | 登録日 | 2022-12-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Mol.Cell, 83, 2023
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8BVW
| RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Abril-Garrido, J, Dienemann, C, Grabbe, F, Velychko, T, Lidschreiber, M, Wang, H, Cramer, P. | 登録日 | 2022-12-20 | 公開日 | 2023-05-03 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Mol.Cell, 83, 2023
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8T8M
| Quis-bound intermediate mGlu5 | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nb43 | 著者 | Krishna Kumar, K, Wang, H, Kobilka, B.K. | 登録日 | 2023-06-22 | 公開日 | 2023-10-11 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Stepwise activation of a metabotropic glutamate receptor. Nature, 2024
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8T6J
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8T7H
| Quis-bound intermediate mGlu5 | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nanobody 43 | 著者 | Krishna Kumar, K, Wang, H, Kobilka, B.K. | 登録日 | 2023-06-20 | 公開日 | 2023-10-11 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Stepwise activation of a metabotropic glutamate receptor. Nature, 2024
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2RBL
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2RB8
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3G3N
| PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one | 分子名称: | 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, MAGNESIUM ION, ... | 著者 | Castano, T, Wang, H. | 登録日 | 2009-02-02 | 公開日 | 2009-04-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors Chemmedchem, 4, 2009
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3ISP
| Crystal structure of ArgP from Mycobacterium tuberculosis | 分子名称: | HTH-type transcriptional regulator Rv1985c/MT2039 | 著者 | Zhou, X, Lou, Z, Sheng, F, Bartlam, M, Wang, H, Rao, Z. | 登録日 | 2009-08-27 | 公開日 | 2010-02-16 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal Structure of ArgP from Mycobacterium tuberculosis Confirms Two Distinct Conformations of Full-length LysR Transcriptional Regulators and Reveals Its Function in DNA Binding and Transcriptional Regulation. J.Mol.Biol., 2009
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2QC3
| Crystal structure of MCAT from Mycobacterium tuberculosis | 分子名称: | ACETIC ACID, Malonyl CoA-acyl carrier protein transacylase | 著者 | Li, Z, Huang, Y, Ge, J, Bartlam, M, Wang, H, Rao, Z. | 登録日 | 2007-06-19 | 公開日 | 2007-08-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Crystal Structure of MCAT from Mycobacterium tuberculosis Reveals Three New Catalytic Models. J.Mol.Biol., 371, 2007
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7T2G
| CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP) | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Seven, A.B, Qu, Q, Robertson, M.J, Wang, H, Kobilka, B.K, Skiniotis, G. | 登録日 | 2021-12-04 | 公開日 | 2022-12-07 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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4KUL
| Crystal structure of N-terminal acetylated yeast Sir3 BAH domain V83P mutant | 分子名称: | Regulatory protein SIR3 | 著者 | Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M. | 登録日 | 2013-05-22 | 公開日 | 2013-08-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol., 20, 2013
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4KUI
| Crystal structure of N-terminal acetylated yeast Sir3 BAH domain | 分子名称: | ACETIC ACID, ISOPROPYL ALCOHOL, Regulatory protein SIR3 | 著者 | Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M. | 登録日 | 2013-05-22 | 公開日 | 2013-08-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol., 20, 2013
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4KUD
| Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast nucleosome core particle | 分子名称: | Histone H2A.2, Histone H2B.1, Histone H3, ... | 著者 | Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M. | 登録日 | 2013-05-22 | 公開日 | 2013-08-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.203 Å) | 主引用文献 | N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol., 20, 2013
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4LH6
| Crystal structure of a LigA inhibitor | 分子名称: | 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide, ACETATE ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... | 著者 | Benenato, K, Wang, H, Mcguire, H.M, Davis, H, Gao, N, Prince, D.B, Jahic, H, Stokes, S.S, Boriack-Sjodin, P.A. | 登録日 | 2013-06-30 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations. Bioorg.Med.Chem.Lett., 24, 2014
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3NGW
| Crystal Structure of Molybdopterin-guanine dinucleotide biosynthesis protein A from Archaeoglobus fulgidus, Northeast Structural Genomics Consortium Target GR189 | 分子名称: | CALCIUM ION, Molybdopterin-guanine dinucleotide biosynthesis protein A (MobA) | 著者 | Forouhar, F, Neely, H, Seetharaman, J, Patel, P, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-06-13 | 公開日 | 2010-08-11 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target GR189 To be Published
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3QFI
| X-ray crystal structure of transcriptional regulator (EF0465) from Enterococcus faecalis, Northeast Structural Genomics Consortium Target EfR190 | 分子名称: | Transcriptional regulator | 著者 | Forouhar, F, Neely, H, Seetharaman, J, Wang, H, Ciccosanti, C, Mao, L, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Tong, L, Hun, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-01-21 | 公開日 | 2011-03-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | X-ray crystal structure of transcriptional regulator (EF0465) from Enterococcus faecalis, Northeast Structural Genomics Consortium Target EfR190 To be Published
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3QWE
| Crystal structure of the N-terminal domain of the GEM interacting protein | 分子名称: | GEM-interacting protein, UNKNOWN ATOM OR ION | 著者 | Guan, X, Tempel, W, Tong, Y, Shen, L, Wang, H, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-02-28 | 公開日 | 2011-03-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the N-terminal domain of the GEM interacting protein to be published
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5A8H
| cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB OF BROADLY NEUTRALIZING ANTIBODY 17B, FAB OF BROADLY NEUTRALIZING ANTIBODY 8ANC195 VARIANT G52K5, ... | 著者 | Scharf, L, Wang, H, Gao, H, Chen, S, McDowall, A, Bjorkman, P. | 登録日 | 2015-07-15 | 公開日 | 2015-08-05 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (23 Å) | 主引用文献 | Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env. Cell, 162, 2015
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5A7X
| negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB OF BROADLY NEUTRALIZING ANTIBODY 17B, FAB OF BROADLY NEUTRALIZING ANTIBODY 8ANC195, ... | 著者 | Scharf, L, Wang, H, Gao, H, Chen, S, McDowall, A, Bjorkman, P. | 登録日 | 2015-07-10 | 公開日 | 2015-08-05 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (17 Å) | 主引用文献 | Broadly Neutralizing Antibody 8Anc195 Recognizes Closed and Open States of HIV-1 Env. Cell(Cambridge,Mass.), 162, 2015
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1Q2I
| NMR SOLUTION STRUCTURE OF A PEPTIDE FROM THE MDM-2 BINDING DOMAIN OF THE P53 PROTEIN THAT IS SELECTIVELY CYTOTOXIC TO CANCER CELLS | 分子名称: | PNC27 | 著者 | Rosal, R, Pincus, M.R, Brandt-Rauf, P.W, Fine, R.L, Wang, H. | 登録日 | 2003-07-24 | 公開日 | 2004-03-16 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells Biochemistry, 43, 2004
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8HLM
| Crystal structure of p53/BCL2 fusion complex (complex 2) | 分子名称: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | 著者 | Guo, M, Wang, H, Wei, H, Chen, Y. | 登録日 | 2022-11-30 | 公開日 | 2023-07-26 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.522 Å) | 主引用文献 | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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