4LH6

Crystal structure of a LigA inhibitor

Summary for 4LH6

• Entry DOI: 10.2210/pdb4lh6/pdb
• Related: 4LH7
• Descriptor: DNA ligase, 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... (6 entities in total)
• Functional Keywords: protein-inhibitor complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Enterococcus faecalis
• Total number of polymer chains: 1
• Total formula weight: 37574.79

Authors

Benenato, K.,Wang, H.,Mcguire, H.M.,Davis, H.,Gao, N.,Prince, D.B.,Jahic, H.,Stokes, S.S.,Boriack-Sjodin, P.A. (deposition date: 2013-06-30, release date: 2013-12-25, Last modification date: 2024-02-28)

• Primary citation: Murphy-Benenato, K.,Wang, H.,McGuire, H.M.,Davis, H.E.,Gao, N.,Prince, D.B.,Jahic, H.,Stokes, S.S.,Boriack-Sjodin, P.A.; Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations.; Bioorg.Med.Chem.Lett., 24:360-366, 2014; PubMed: 24287382; DOI: 10.1016/j.bmcl.2013.11.007

Experimental method

X-RAY DIFFRACTION (1.65 Å)