5W33
 
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5W35
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5W36
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5WMM
 | | Crystal structure of an adenylation domain interrupted by a methylation domain (AMA4) from nonribosomal peptide synthetase TioS | | 分子名称: | (2S)-2-amino-3-methylbutanoyl (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl hydrogen (S)-phosphate, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Pang, A.H, Mori, S, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2017-07-30 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis for backbone N-methylation by an interrupted adenylation domain.
Nat. Chem. Biol., 14, 2018
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5WHF
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4Z74
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4Z71
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4Z72
 | | Crystal structure of inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with two phosphate ions | | 分子名称: | CALCIUM ION, Inorganic pyrophosphatase, PHOSPHATE ION | | 著者 | Pratt, A.C, Biswas, T, Barnard-Britson, S, Tsodikov, O.V. | | 登録日 | 2015-04-06 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.352 Å) | | 主引用文献 | Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis.
J.Struct.Biol., 192, 2015
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4Z70
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4Z73
 | | Crystal structure of inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with a phosphate ion and an inorganic pyrophosphate | | 分子名称: | Inorganic pyrophosphatase, MANGANESE (II) ION, PHOSPHATE ION, ... | | 著者 | Pratt, A.C, Biswas, T, Tsodikov, O.V. | | 登録日 | 2015-04-06 | | 公開日 | 2015-08-26 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis.
J.Struct.Biol., 192, 2015
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6B0U
 | | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a Lys-containing peptide | | 分子名称: | COENZYME A, N-acetyltransferase Eis, Synthetic peptide ATKAPAKKA | | 著者 | Biswas, T, Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2017-09-15 | | 公開日 | 2018-01-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.
Biochemistry, 57, 2018
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6B3T
 | | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a 1,2,4-triazino[5,6b]indole-3-thioether inhibitor analogue 39b | | 分子名称: | 8-fluoro-5-methyl-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole, COENZYME A, N-acetyltransferase Eis, ... | | 著者 | Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Ngo, H.X, Tsodikov, O.V. | | 登録日 | 2017-09-24 | | 公開日 | 2018-04-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.
ACS Infect Dis, 4, 2018
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6BZQ
 | | Crystal structure of halogenase PltM in complex with FAD | | 分子名称: | BROMIDE ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2017-12-25 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10, 2019
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6BZZ
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6BZA
 | | Crystal structure of halogenase PltM in complex with phloroglucinol and FAD | | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Halogenase PltM, ... | | 著者 | Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2017-12-22 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10, 2019
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6BZT
 | | Crystal structure of halogenase PltM L111Y mutant in complex with FAD | | 分子名称: | BROMIDE ION, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2017-12-26 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10, 2019
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6BZN
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6BZI
 | | Crystal structure of halogenase PltM in complex with ethyl mercury and mercury | | 分子名称: | CALCIUM ION, ETHYL MERCURY ION, GLYCEROL, ... | | 著者 | Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2017-12-24 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10, 2019
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5DBJ
 | | Crystal structure of halogenase PltA | | 分子名称: | CHLORIDE ION, FADH2-dependent halogenase PltA, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Pang, A.H, Tsodikov, O.V. | | 登録日 | 2015-08-21 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway.
J.Struct.Biol., 192, 2015
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5E8G
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5EBV
 | | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 11c and CoA | | 分子名称: | 5-(4-chlorophenyl)-~{N}-[3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)propyl]-4-methyl-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine, CHLORIDE ION, COENZYME A, ... | | 著者 | Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2015-10-19 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.
Acs Chem.Biol., 11, 2016
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5EC4
 | | Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 13g and CoA | | 分子名称: | 5-(3-chlorophenyl)-4-methyl-~{N}-(3-morpholin-4-ylpropyl)-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine, COENZYME A, Enhanced intracellular survival protein | | 著者 | Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2015-10-20 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.
Acs Chem.Biol., 11, 2016
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5E8I
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4RPA
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4RV9
 | | Crystal structure of MtmC in complex with SAH | | 分子名称: | ACETATE ION, CHLORIDE ION, D-mycarose 3-C-methyltransferase, ... | | 著者 | Hou, C, Chen, J.-M, Rohr, J, Tsodikov, O.V. | | 登録日 | 2014-11-25 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain.
Biochemistry, 54, 2015
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