6B3T
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a 1,2,4-triazino[5,6b]indole-3-thioether inhibitor analogue 39b
Summary for 6B3T
Entry DOI | 10.2210/pdb6b3t/pdb |
Descriptor | N-acetyltransferase Eis, COENZYME A, 8-fluoro-5-methyl-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole, ... (6 entities in total) |
Functional Keywords | transferase, tuberculosis, aminoglycoside, resistance, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 1 |
Total formula weight | 47231.14 |
Authors | Gajadeera, C.S.,Hou, C.,Garneau-Tsodikova, S.,Ngo, H.X.,Tsodikov, O.V. (deposition date: 2017-09-24, release date: 2018-04-04, Last modification date: 2023-10-04) |
Primary citation | Ngo, H.X.,Green, K.D.,Gajadeera, C.S.,Willby, M.J.,Holbrook, S.Y.L.,Hou, C.,Garzan, A.,Mayhoub, A.S.,Posey, J.E.,Tsodikov, O.V.,Garneau-Tsodikova, S. Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis. ACS Infect Dis, 4:1030-1040, 2018 Cited by PubMed: 29601176DOI: 10.1021/acsinfecdis.8b00074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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