6B3T

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a 1,2,4-triazino[5,6b]indole-3-thioether inhibitor analogue 39b

Summary for 6B3T

• Entry DOI: 10.2210/pdb6b3t/pdb
• Descriptor: N-acetyltransferase Eis, COENZYME A, 8-fluoro-5-methyl-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole, ... (6 entities in total)
• Functional Keywords: transferase, tuberculosis, aminoglycoside, resistance, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 47231.14

Authors

Gajadeera, C.S.,Hou, C.,Garneau-Tsodikova, S.,Ngo, H.X.,Tsodikov, O.V. (deposition date: 2017-09-24, release date: 2018-04-04, Last modification date: 2023-10-04)

• Primary citation: Ngo, H.X.,Green, K.D.,Gajadeera, C.S.,Willby, M.J.,Holbrook, S.Y.L.,Hou, C.,Garzan, A.,Mayhoub, A.S.,Posey, J.E.,Tsodikov, O.V.,Garneau-Tsodikova, S.; Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.; ACS Infect Dis, 4:1030-1040, 2018; PubMed: 29601176; DOI: 10.1021/acsinfecdis.8b00074

Experimental method

X-RAY DIFFRACTION (2.4 Å)