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Human carbonic anhydrase II with a sulfonamide inhibitor
分子名称:	(4-SULFAMOYL-PHENYL)-THIOCARBAMIC ACID O-(2-THIOPHEN-3-YL-ETHYL) ESTER, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, ...
著者	Behnke, C.A, Le Trong, I, Merritt, E.A, Teller, D.C, Stenkamp, R.E.
登録日	2009-10-01
公開日	2010-05-12
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (0.9 Å)
主引用文献	Atomic resolution studies of carbonic anhydrase II. Acta Crystallogr.,Sect.D, 66, 2010

3KFL

Leishmania major methionyl-tRNA synthetase in complex with methionyladenylate and pyrophosphate
分子名称:	1,2-ETHANEDIOL, FORMIC ACID, MAGNESIUM ION, ...
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-10-27
公開日	2010-10-27
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie, 93, 2011

3KKK

Y92C catalytic residue mutant of Phosphoglycerate Mutase from Plasmodium falciparum
分子名称:	Phosphoglycerate mutase
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-11-05
公開日	2009-11-17
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.08 Å)
主引用文献	Structure of a phosphoglycerate mutase from Plasmodium falciparum To be Published

3LSQ

Trypanosoma brucei seryl-tRNA synthetase
分子名称:	MALONATE ION, SODIUM ION, Seryl-tRNA synthetase
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2010-02-12
公開日	2010-03-02
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei. to be published

3LSS

Trypanosoma brucei seryl-tRNA synthetase in complex with ATP
分子名称:	ADENOSINE-5'-TRIPHOSPHATE, MALONATE ION, SODIUM ION, ...
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2010-02-12
公開日	2010-03-02
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei. to be published

3LX3

Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS) in complex with xanthopterin
分子名称:	2-amino-1,5-dihydropteridine-4,6-dione, 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2010-02-24
公開日	2010-03-09
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.55 Å)
主引用文献	Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites. to be published

3M0N

Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS), E37A catalytic residue mutant
分子名称:	PTERINE, Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2010-03-03
公開日	2010-04-07
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites. to be published

3M4P

Entamoeba histolytica asparaginyl-tRNA synthetase (AsnRS) in complex with asparaginyl-adenylate
分子名称:	4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, Asparaginyl-tRNA synthetase, putative, ...
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2010-03-11
公開日	2010-03-23
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.83 Å)
主引用文献	X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica. to be published

3LZE

Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS), E37C catalytic residue mutant
分子名称:	PTERINE, Putative 6-pyruvoyl tetrahydrobiopterin synthase, ZINC ION
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2010-03-01
公開日	2010-04-07
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structural analysis of the dual-functional 6-pyruvoyltetrahydropterin synthase from Malaria parasites. to be published

3M4Q

Entamoeba histolytica asparaginyl-tRNA synthetase (AsnRS)
分子名称:	Asparaginyl-tRNA synthetase, putative
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2010-03-11
公開日	2010-03-23
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica. to be published

5SWH

c-Src V281C kinase domain in complex with Rao-IV-151
分子名称:	(2R)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanami de, Proto-oncogene tyrosine-protein kinase Src
著者	Merritt, E.A, Dieter, E.M.
登録日	2016-08-08
公開日	2017-08-16
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions Mol.Cell, 2019

2CBP

CUCUMBER BASIC PROTEIN, A BLUE COPPER PROTEIN
分子名称:	COPPER (II) ION, CUCUMBER BASIC PROTEIN
著者	Guss, J.M, Freeman, H.C.
登録日	1996-03-16
公開日	1997-04-21
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	The structure of a phytocyanin, the basic blue protein from cucumber, refined at 1.8 A resolution. J.Mol.Biol., 262, 1996

2B4T

Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Angstrom resolution reveals intriguing extra electron density in the active site
分子名称:	4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, glyceraldehyde-3-phosphate dehydrogenase
著者	Robien, M.A, Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2005-09-26
公開日	2005-10-04
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site Proteins, 62, 2006

2F67

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.6 A resolution with BENZO[CD]INDOL-2(1H)-ONE bound
分子名称:	BENZO[CD]INDOL-2(1H)-ONE, GLYCEROL, Nucleoside 2-deoxyribosyltransferase, ...
著者	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2005-11-28
公開日	2005-12-06
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2F62

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.5 A resolution with (2-ETHYLPHENYL)METHANOL bound
分子名称:	(2-ETHYLPHENYL)METHANOL, GLYCEROL, Nucleoside 2-deoxyribosyltransferase, ...
著者	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2005-11-28
公開日	2005-12-06
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2F2T

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.7 A resolution with 5-Aminoisoquinoline bound
分子名称:	GLYCEROL, ISOQUINOLIN-5-AMINE, Nucleoside 2-deoxyribosyltransferase, ...
著者	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2005-11-17
公開日	2005-11-22
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2F64

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.6 A resolution with 1-METHYLQUINOLIN-2(1H)-ONE bound
分子名称:	1-METHYLQUINOLIN-2(1H)-ONE, GLYCEROL, Nucleoside 2-deoxyribosyltransferase, ...
著者	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2005-11-28
公開日	2005-12-06
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2A0K

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.8 A resolution
分子名称:	GLYCEROL, Nucleoside 2-deoxyribosyltransferase, SULFATE ION
著者	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2005-06-16
公開日	2005-07-26
最終更新日	2021-10-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2B4R

Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Angstrom Resolution reveals intriguing extra electron density in the active site
分子名称:	4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者	Robien, M.A, Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2005-09-26
公開日	2005-10-04
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site Proteins, 62, 2006

2GJF

NMR structure of the computationally designed procarboxypeptidase-A (1AYE) domain
分子名称:	DESIGNED PROTEIN
著者	Reichow, S.
登録日	2006-03-30
公開日	2007-01-16
最終更新日	2022-03-09
実験手法	SOLUTION NMR
主引用文献	High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. J.Mol.Biol., 366, 2007

1LT3

HEAT-LABILE ENTEROTOXIN DOUBLE MUTANT N40C/G166C
分子名称:	HEAT-LABILE ENTEROTOXIN, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者	Van Den Akker, F, Hol, W.G.J.
登録日	1997-04-12
公開日	1997-07-07
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit. Protein Sci., 6, 1997

1LTG

THE ARG7LYS MUTANT OF HEAT-LABILE ENTEROTOXIN EXHIBITS GREAT FLEXIBILITY OF ACTIVE SITE LOOP 47-56 OF THE A SUBUNIT
分子名称:	HEAT-LABILE ENTEROTOXIN
著者	Van Den Akker, F, Hol, W.G.J.
登録日	1995-06-13
公開日	1995-09-15
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit. Biochemistry, 34, 1995

5T0P

c-Src kinase domain in complex with Rao-IV-151
分子名称:	(2E)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src
著者	Dieter, E.M, Merritt, E.A, Maly, D.J.
登録日	2016-08-16
公開日	2017-08-23
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	A chemical genetic method for conformation-selective kinase inhibition To Be Published

5SYS

c-Src V281C bound to N-[3-({6-[(1E)-2-cyano-3-(methylamino)-3-oxoprop-1-en-1-yl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide inhibitor
分子名称:	N-[3-({6-[(2S)-2-cyano-3-(methylamino)-3-oxopropyl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide, Proto-oncogene tyrosine-protein kinase Src
著者	Dieter, E.M, Merritt, E.A, Maly, D.J.
登録日	2016-08-11
公開日	2017-08-16
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions Mol.Cell, 2019

5TEH

c-Src V281C kinase domain in complex with Rao-IV-156
分子名称:	(2S)-3-[4-amino-7-(2-methoxyethyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanamide, Proto-oncogene tyrosine-protein kinase Src
著者	Dieter, E.M, Merritt, E.A, Maly, D.J.
登録日	2016-09-21
公開日	2017-09-27
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.99 Å)
主引用文献	A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions Mol.Cell, 2019

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