5SWH

c-Src V281C kinase domain in complex with Rao-IV-151

Summary for 5SWH

• Entry DOI: 10.2210/pdb5swh/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, (2R)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanami de (3 entities in total)
• Functional Keywords: active conformation, covalently-linked inihibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 66343.16

Authors

Merritt, E.A.,Dieter, E.M. (deposition date: 2016-08-08, release date: 2017-08-16, Last modification date: 2023-10-04)

• Primary citation: Register, A.C.,Maly, D.J.; A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions; Mol.Cell, 2019

Experimental method

X-RAY DIFFRACTION (2.5 Å)