5SWH
c-Src V281C kinase domain in complex with Rao-IV-151
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32730.7 | 2 | UniProt (P00523) Pfam (PF07714) In PDB | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | A, B | (2R)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanami de | non-polymer | 440.9 | 2 | Chemie (71D) | |||
| 3 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A, B: 252 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
| Gln 251 | - | expression tag |
| Cys 281 | Val 281 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65461.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 881.9 | |
| All* | Total formula weight | 66343.2 |
