Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.8 A resolution

Summary for 2A0K

DescriptorNucleoside 2-deoxyribosyltransferase, SULFATE ION, GLYCEROL, ... (4 entities in total)
Functional Keywordssgpp, structural genomics, psi, protein structure initiative, nucleoside 2-deoxyribosyltransferase, structural genomics of pathogenic protozoa consortium, transferase
Biological sourceTrypanosoma brucei
Total number of polymer chains2
Total molecular weight37704.45
Bosch, J.,Robien, M.A.,Hol, W.G.J.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (deposition date: 2005-06-16, release date: 2005-07-26, Last modification date: 2011-07-13)
Primary citation
Bosch, J.,Robien, M.A.,Mehlin, C.,Boni, E.,Riechers, A.,Buckner, F.S.,Van Voorhis, W.C.,Myler, P.J.,Worthey, E.A.,DeTitta, G.,Luft, J.R.,Lauricella, A.,Gulde, S.,Anderson, L.A.,Kalyuzhniy, O.,Neely, H.M.,Ross, J.,Earnest, T.N.,Soltis, M.,Schoenfeld, L.,Zucker, F.,Merritt, E.A.,Fan, E.,Verlinde, C.L.,Hol, W.G.J.
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
J.Med.Chem., 49:5939-5946, 2006
PubMed: 17004709 (PDB entries with the same primary citation)
DOI: 10.1021/jm060429m
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.206202.2%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2a0k
no rotation
Molmil generated image of 2a0k
rotated about x axis by 90°
Molmil generated image of 2a0k
rotated about y axis by 90°
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