5EA6
| Crystal Structure of Inhibitor BTA-9881 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | (9~{b}~{R})-9~{b}-(4-chlorophenyl)-1-pyridin-3-ylcarbonyl-2,3-dihydroimidazo[5,6]pyrrolo[1,2-~{a}]pyridin-5-one, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Fusion glycoprotein F0, ... | Authors: | Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. | Deposit date: | 2015-10-15 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
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5EA5
| Crystal Structure of Inhibitor TMC-353121 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, D(-)-TARTARIC ACID, ... | Authors: | Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. | Deposit date: | 2015-10-15 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
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5EA7
| Crystal Structure of Inhibitor BMS-433771 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 1-cyclopropyl-3-[[1-(4-oxidanylbutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Fusion glycoprotein F0, ... | Authors: | Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. | Deposit date: | 2015-10-15 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.851 Å) | Cite: | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
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5EA8
| Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, D(-)-TARTARIC ACID, Fusion glycoprotein F0, ... | Authors: | Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. | Deposit date: | 2015-10-15 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
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5EA4
| Crystal Structure of Inhibitor JNJ-49153390 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 3-[[5-bromanyl-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-1-cyclopropyl-imidazo[4,5-c]pyridin-2-one, Fusion glycoprotein F0, ... | Authors: | Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P. | Deposit date: | 2015-10-15 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
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5EA3
| Crystal Structure of Inhibitor JNJ-2408068 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[2-[[1-(2-azanylethyl)piperidin-4-yl]amino]-4-methyl-benzimidazol-1-yl]methyl]-6-methyl-pyridin-3-ol, Fusion glycoprotein F0, ... | Authors: | Battles, M.B, McLellan, J.S, Arnoult, E, Langedijk, J.P, Roymans, D. | Deposit date: | 2015-10-15 | Release date: | 2015-12-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat.Chem.Biol., 12, 2016
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5FHA
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5FHB
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5FHC
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3R0M
| Crystal structure of anti-HIV llama VHH antibody A12 | Descriptor: | Llama VHH A12, SULFATE ION | Authors: | Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D. | Deposit date: | 2011-03-08 | Release date: | 2012-03-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Single-Headed Immunoglobulins Efficiently Penetrate CD4-Binding Site and Effectively Neutralize HIV-1 To be Published
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3RJQ
| Crystal structure of anti-HIV llama VHH antibody A12 in complex with C186 gp120 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C186 gp120, Llama VHH A12 | Authors: | Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D. | Deposit date: | 2011-04-15 | Release date: | 2012-05-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Crystal structure of anti-HIV A12 VHH of llama antibody in complex with C1086 gp120 To be Published
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3RY8
| Structural basis for norovirus inhibition and fucose mimicry by citrate | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, Capsid protein | Authors: | Hansman, G.S, McLellan, J.S, Kwong, P.D. | Deposit date: | 2011-05-11 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural basis for norovirus inhibition and fucose mimicry by citrate. J.Virol., 86, 2012
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7KBB
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7KBA
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6APC
| Crystal Structure of Infant Antibody ADI-19425 | Descriptor: | Epididymis luminal protein 214, IGL@ protein, SULFATE ION | Authors: | Gilman, M.S.A, McLellan, J.S. | Deposit date: | 2017-08-17 | Release date: | 2018-03-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity, 48, 2018
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6APD
| Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 | Descriptor: | AM22 Fab Heavy Chain,IGH@ protein, AM22 Fab Light Chain,Uncharacterized protein, Fusion glycoprotein F0,Envelope glycoprotein, ... | Authors: | Wrapp, D, McLellan, J.S. | Deposit date: | 2017-08-17 | Release date: | 2018-03-21 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity, 48, 2018
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6APB
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3V7A
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7L3N
| SARS-CoV 2 Spike Protein bound to LY-CoV555 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LY-CoV555 Fab heavy chain, ... | Authors: | Goldsmith, J.A, McLellan, J.S. | Deposit date: | 2020-12-18 | Release date: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection. Biorxiv, 2020
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5W24
| Crystal Structure of 5C4 Fab | Descriptor: | (R,R)-2,3-BUTANEDIOL, 5C4 Fab Heavy Chain, 5C4 Fab Light Chain | Authors: | Battles, M.B, McLellan, J.S, Taher, N.M. | Deposit date: | 2017-06-05 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein. Nat Commun, 8, 2017
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7L7R
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7KX4
| Anti-CCHFV ADI-36121 Fab | Descriptor: | ADI-36121 Fab heavy chain, ADI-36121 Fab light chain | Authors: | Mishra, A.K, McLellan, J.S. | Deposit date: | 2020-12-03 | Release date: | 2021-12-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies. Science, 375, 2022
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7LVW
| Structure of RSV F in Complex with VHH Cl184 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, F-VHH-Cl184, ... | Authors: | Hsieh, C.-L, McLellan, J.S. | Deposit date: | 2021-02-26 | Release date: | 2021-03-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody. J.Virol., 95, 2021
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7LVU
| Structure of RSV F-directed VHH Cl184 | Descriptor: | F-VHH-Cl184 | Authors: | Hsieh, C.-L, McLellan, J.S. | Deposit date: | 2021-02-26 | Release date: | 2021-03-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody. J.Virol., 95, 2021
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7LUC
| Cryo-EM structure of RSV preF bound by Fabs 32.4K and 01.4B | Descriptor: | 01.4B Fab Heavy chain, 01.4B Fab Light chain, 32.4K Fab Heavy chain, ... | Authors: | Wrapp, D, McLellan, J.S. | Deposit date: | 2021-02-22 | Release date: | 2021-04-21 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses. Immunity, 54, 2021
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