4RKY
 
 | | Crystal structure of DJ-1 isoform X1 | | 分子名称: | Protein DJ-1 | | 著者 | Liddington, R.C. | | 登録日 | 2014-10-14 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
J.Neurosci., 34, 2014
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4RKW
 | | Crystal structure of DJ-1 | | 分子名称: | Protein DJ-1 | | 著者 | Liddington, R.C. | | 登録日 | 2014-10-14 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
J.Neurosci., 34, 2014
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6UM3
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6BDN
 | | Crystal structure of human TAO3 kinase binding ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Aleshin, A.E, Bankton, L.A, Pinkerton, A, Courtneidge, S.A, Liddington, R.C. | | 登録日 | 2017-10-23 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of human TAO3 kinase binding ADP
To Be Published
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1A37
 | | 14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE | | 分子名称: | 14-3-3 PROTEIN ZETA, PS-RAF259 PEPTIDE LSQRQRST(SEP)TPNVHM | | 著者 | Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. | | 登録日 | 1998-01-28 | | 公開日 | 1999-03-02 | | 最終更新日 | 2016-08-17 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
J.Biol.Chem., 273, 1998
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7MHE
 | | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7957 | | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]benzene-1-sulfonyl}morpholine, Fatty acid synthase | | 著者 | Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
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7MHD
 | | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635 | | 分子名称: | Fatty acid synthase, N,N-diethyl-4-{2-[(2-fluorophenyl)methyl]-1,3-thiazol-4-yl}benzene-1-sulfonamide | | 著者 | Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
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1A38
 | | 14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE | | 分子名称: | 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP) | | 著者 | Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. | | 登録日 | 1998-01-28 | | 公開日 | 1999-03-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
J.Biol.Chem., 273, 1998
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1AOX
 | | I DOMAIN FROM INTEGRIN ALPHA2-BETA1 | | 分子名称: | INTEGRIN ALPHA 2 BETA, MAGNESIUM ION | | 著者 | Emsley, J, King, S.L, Bergelson, J.M, Liddington, R.C. | | 登録日 | 1997-07-13 | | 公開日 | 1998-11-25 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the I domain from integrin alpha2beta1.
J.Biol.Chem., 272, 1997
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4E0S
 | | Crystal Structure of C5b-6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ... | | 著者 | Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C. | | 登録日 | 2012-03-05 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (4.21 Å) | | 主引用文献 | Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
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3T5O
 | | Crystal Structure of human Complement Component C6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Complement component C6, ... | | 著者 | Aleshin, A.E, Stec, B, Bankston, L.A, DiScipio, R.G, Liddington, R.C. | | 登録日 | 2011-07-27 | | 公開日 | 2012-02-01 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.869 Å) | | 主引用文献 | Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).
J.Biol.Chem., 287, 2012
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5TBP
 | | Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003 | | 分子名称: | ACETATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Aleshin, A.E, Liddington, R.C, Su, Y, Zhang, X. | | 登録日 | 2016-09-12 | | 公開日 | 2017-08-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.
Nat Commun, 8, 2017
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5TFO
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5TFN
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1AB4
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1ACC
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3FKU
 | | Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Neutralizing antibody F10, ... | | 著者 | Hwang, W.C, Santelli, E, Stec, B, Wei, G, Cadwell, G, Bankston, L.A, Sui, J, Perez, S, Aird, D, Chen, L.M, Ali, M, Murakami, A, Yammanuru, A, Han, T, Cox, N, Donis, R.O, Liddington, R.C, Marasco, W.A. | | 登録日 | 2008-12-17 | | 公開日 | 2009-02-24 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.
Nat.Struct.Mol.Biol., 16, 2009
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2M4N
 | | Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans | | 分子名称: | Protein AFD-1, isoform a | | 著者 | Harris, R, Hillerich, B, Ahmed, M, Bonanno, J.B, Chamala, S, Evans, B, Lafleur, J, Hammonds, J, Washington, E, Stead, M, Love, J, Attonito, J, Seidel, R.D, Liddington, R.C, Weis, W.I, Nelson, W.J, Girvin, M.E, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT) | | 登録日 | 2013-02-07 | | 公開日 | 2013-03-20 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans
To be Published
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2O3O
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2OTN
 | | Crystal structure of the catalytically active form of diaminopimelate epimerase from Bacillus anthracis | | 分子名称: | Diaminopimelate epimerase | | 著者 | Matho, M.H, Fukuda, K, Santelli, E, Jaroszewski, L, Liddington, R.C, Roper, D. | | 登録日 | 2007-02-08 | | 公開日 | 2008-03-04 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure and inhibition of a catalytically active form of diaminopimelate epimerase (DapF)from Bacillus anthracis
To be Published
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4N8R
 | | Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008 | | 分子名称: | 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha | | 著者 | Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. | | 登録日 | 2013-10-17 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
Chem.Biol., 21, 2014
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4N5G
 | | Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012 | | 分子名称: | 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha | | 著者 | Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. | | 登録日 | 2013-10-09 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
Chem.Biol., 21, 2014
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3PMD
 | | Crystal structure of the sporulation inhibitor pXO1-118 from Bacillus anthracis | | 分子名称: | CHLORIDE ION, Conserved domain protein, UNDECANOIC ACID | | 著者 | Stranzl, G.R, Santelli, E, Bankston, L.A, La Clair, C, Bobkov, A, Schwarzenbacher, R, Godzik, A, Perego, M, Grynberg, M, Liddington, R.C. | | 登録日 | 2010-11-16 | | 公開日 | 2011-01-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structural Insights into Inhibition of Bacillus anthracis Sporulation by a Novel Class of Non-heme Globin Sensor Domains.
J.Biol.Chem., 286, 2011
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4ON1
 | | Crystal Structure of metalloproteinase-II from Bacteroides fragilis | | 分子名称: | GLYCEROL, Putative metalloprotease II, ZINC ION | | 著者 | Aleshin, A.E, Liddington, R.C, Shiryaev, S.A, Strongin, A.Y. | | 登録日 | 2014-01-28 | | 公開日 | 2014-04-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island.
Febs J., 281, 2014
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3PMC
 | | Crystal structure of the sporulation inhibitor pXO2-61 from Bacillus anthracis | | 分子名称: | CHLORIDE ION, IODIDE ION, Uncharacterized protein pXO2-61/BXB0075/GBAA_pXO2_0075 | | 著者 | Stranzl, G.R, Santelli, E, Bankston, L.A, La Clair, C, Bobkov, A, Schwarzenbacher, R, Godzik, A, Perego, M, Grynberg, M, Liddington, R.C. | | 登録日 | 2010-11-16 | | 公開日 | 2011-01-19 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Structural Insights into Inhibition of Bacillus anthracis Sporulation by a Novel Class of Non-heme Globin Sensor Domains.
J.Biol.Chem., 286, 2011
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