5TFN

CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE in super-open conformation

Summary for 5TFN

• Entry DOI: 10.2210/pdb5tfn/pdb
• Descriptor: NS2B-NS3 Protease CHIMERA,Genome polyprotein (2 entities in total)
• Functional Keywords: flavivirus, serine protease, zika virus, viral protein
• Biological source: Zika virus (ZIKV); More
• Cellular location: Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: Q32ZE1
• Total number of polymer chains: 2
• Total formula weight: 51024.83

Authors

Aleshin, A.E.,Bankston, L.,Liddington, R.C. (deposition date: 2016-09-26, release date: 2017-10-25, Last modification date: 2023-10-04)

• Primary citation: Aleshin, A.E.,Bankston, L.,Shiryaev, S.A.,Terskikh, A.,Strongin, A.,Liddington, R.C.; A novel conformation for the Zika virus NS2B-NS3 protease offers new insights into biological regulation and inhibitor design.; To Be Published,

Experimental method

X-RAY DIFFRACTION (3 Å)