1LVG
| Crystal structure of mouse guanylate kinase in complex with GMP and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Guanylate kinase, ... | Authors: | Sekulic, N, Shuvalova, L, Spangenberg, O, Konrad, M, Lavie, A. | Deposit date: | 2002-05-28 | Release date: | 2002-12-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characterization of the closed
conformation of mouse guanylate kinase. J.Biol.Chem., 277, 2002
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2HAZ
| Crystal structure of the first fibronectin domain of human NCAM1 | Descriptor: | Neural cell adhesion molecule 1, SODIUM ION | Authors: | Sekulic, N, Lavie, A. | Deposit date: | 2006-06-13 | Release date: | 2006-10-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation. J.Biol.Chem., 281, 2006
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5DND
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5DNE
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5DNC
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1XYM
| THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID | Descriptor: | D-glucose, HYDROXIDE ION, MAGNESIUM ION, ... | Authors: | Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D. | Deposit date: | 1993-12-07 | Release date: | 1994-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid. Biochemistry, 33, 1994
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1XYL
| THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID | Descriptor: | HYDROXIDE ION, MAGNESIUM ION, XYLOSE ISOMERASE | Authors: | Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D. | Deposit date: | 1993-12-07 | Release date: | 1994-05-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid. Biochemistry, 33, 1994
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6AQB
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6C4S
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6C4U
| Engineered FHA with Myc-pTBD peptide | Descriptor: | Forkhead-associated 1, GLYCEROL, Myc-pTBD peptide | Authors: | Kall, S.L, Lavie, A. | Deposit date: | 2018-01-12 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Generating a recombinant phosphothreonine-binding domain for a phosphopeptide of the human transcription factor, c-Myc. N Biotechnol, 45, 2018
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6CQ7
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5K28
| Structure of the unbound SH3 domain of MLK3 | Descriptor: | Mitogen-activated protein kinase kinase kinase 11 | Authors: | Kall, S.K, Lavie, A. | Deposit date: | 2016-05-18 | Release date: | 2017-12-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3. J. Biol. Chem., 293, 2018
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5K26
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5HW0
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5I4B
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3HP1
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5I3Z
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5I48
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5F52
| Erwinia chrysanthemi L-asparaginase + Aspartic acid | Descriptor: | ASPARTIC ACID, DI(HYDROXYETHYL)ETHER, L-asparaginase | Authors: | Nguyen, H.A, Lavie, A. | Deposit date: | 2015-12-04 | Release date: | 2016-04-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Structural Insight into Substrate Selectivity of Erwinia chrysanthemi l-Asparaginase. Biochemistry, 55, 2016
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3KFX
| Human dCK complex with 5-Me dC and ADP | Descriptor: | 5-METHYL-2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase | Authors: | Hazra, S, Lavie, A. | Deposit date: | 2009-10-28 | Release date: | 2010-09-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry, 49, 2010
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2A2Z
| Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine diphosphate | Descriptor: | 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase, ... | Authors: | Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A. | Deposit date: | 2005-06-23 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization. Biochemistry, 45, 2006
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4PVQ
| Crystal structure of sulfate-bound human l-asparaginase protein | Descriptor: | IODIDE ION, Isoaspartyl peptidase/L-asparaginase, SODIUM ION, ... | Authors: | Nomme, J, Lavie, A. | Deposit date: | 2014-03-18 | Release date: | 2014-03-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. Biochemistry, 51, 2012
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4Q1B
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4Q1D
| Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 9 {2-{[(1R)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine} | Descriptor: | (R)-2-((1-(2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-propylthiazol-4-yl)ethyl)thio)pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | Authors: | Nomme, J, Lavie, A. | Deposit date: | 2014-04-03 | Release date: | 2015-02-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. J.Med.Chem., 57, 2014
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4PVP
| Crystal structure of malonate-bound human L-asparaginase protein | Descriptor: | Isoaspartyl peptidase/L-asparaginase, MALONATE ION, SODIUM ION | Authors: | Nomme, J, Lavie, A. | Deposit date: | 2014-03-18 | Release date: | 2014-03-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. Biochemistry, 51, 2012
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