8BD4
 
 | | TniQ-capped Tns-ATP-dsDNA complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*C)-3'), MAGNESIUM ION, ... | | 著者 | Querques, I, Schmitz, M, Oberli, S, Chanez, C, Jinek, M. | | 登録日 | 2022-10-18 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-01-04 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Structural basis for the assembly of the type V CRISPR-associated transposon complex.
Cell, 185, 2022
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8BD6
 | | Cas12k-sgRNA-dsDNA-TnsC non-productive complex. | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cas12k, DNA, ... | | 著者 | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | | 登録日 | 2022-10-18 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural basis for the assembly of the type V CRISPR-associated transposon complex.
Cell, 185, 2022
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7ZY4
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4BK0
 | | Crystal structure of the KIX domain of human RECQL5 (domain-swapped dimer) | | 分子名称: | ATP-DEPENDENT DNA HELICASE Q5, DI(HYDROXYETHYL)ETHER | | 著者 | Kassube, S.A, Jinek, M, Fang, J, Tsutakawa, S, Nogales, E. | | 登録日 | 2013-04-21 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Mimicry in Transcription Regulation of Human RNA Polymerase II by the DNA Helicase Recql5
Nat.Struct.Mol.Biol., 20, 2013
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5L6D
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5L6E
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6FUW
 | | Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ... | | 著者 | Clerici, M, Faini, M, Jinek, M. | | 登録日 | 2018-02-28 | | 公開日 | 2018-03-21 | | 最終更新日 | 2023-02-22 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Nat. Struct. Mol. Biol., 25, 2018
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6F9N
 | | CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | | 著者 | Clerici, M, Jinek, M. | | 登録日 | 2017-12-14 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
Elife, 6, 2017
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7Z4E
 | | SpCas9 bound to 8-nucleotide complementary DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 8 nucleotide complementary DNA substrate, Target strand of 8 nucleotide complementary DNA substrate, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-03-03 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-14 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4K
 | | SpCas9 bound to 10-nucleotide complementary DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 10-nucleotide complementary DNA substrate, Target strand of 10-nucleotide complementary DNA substrate, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-03-04 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-14 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4G
 | | SpCas9 bound to 12-nucleotide complementary DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 12-nucleotide complementary DNA substrate, Target strand of 12-nucleotide complementary DNA substrate, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-03-03 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-14 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4D
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7Z4I
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7Z4H
 | | SpCas9 bound to 14-nucleotide complementary DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 14-nucleotide complementary DNA substrate, Target strand of 14-nucleotide complementary DNA substrate, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-03-03 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-14 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4J
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7Z4L
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7Z4C
 | | SpCas9 bound to 6 nucleotide complementary DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 6 nucleotide complementary DNA substrate, Target strand of 6 nucleotide complementary DNA substrate, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-03-03 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-14 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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3ICQ
 | | Karyopherin nuclear state | | 分子名称: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | | 登録日 | 2009-07-18 | | 公開日 | 2009-08-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
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3IBV
 | | Karyopherin cytosolic state | | 分子名称: | CALCIUM ION, Exportin-T | | 著者 | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | | 登録日 | 2009-07-17 | | 公開日 | 2009-08-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
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5FQ5
 | | Crystal structure of Cas9-sgRNA-DNA complex solved by native SAD phasing | | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | 著者 | Olieric, V, Weinert, T, Finke, A, Anders, C, Jinek, M, Wang, M. | | 登録日 | 2015-12-07 | | 公開日 | 2016-03-23 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.136 Å) | | 主引用文献 | Data-Collection Strategy for Challenging Native Sad Phasing.
Acta Crystallogr.,Sect.D, 72, 2016
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5AF2
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5NFV
 | | Crystal structure of catalytically inactive FnCas12 mutant bound to an R-loop structure containing a pre-crRNA mimic and full-length DNA target | | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CRISPR-associated endonuclease Cpf1, DNA non-target strand, ... | | 著者 | Swarts, D.C, van der Oost, J, Jinek, M. | | 登録日 | 2017-03-16 | | 公開日 | 2017-06-14 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.
Mol. Cell, 66, 2017
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5NG6
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6QZK
 | | Structure of Clostridium butyricum Argonaute bound to a guide DNA (5' deoxycytidine) and a 19-mer target DNA | | 分子名称: | Clostridium butyricum Argonaute, DNA target (5'-D(T*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*T)-3'), FORMIC ACID, ... | | 著者 | Swarts, D.C, Jinek, M, Hegge, J.W, Van der Oost, J. | | 登録日 | 2019-03-11 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.548 Å) | | 主引用文献 | DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.
Nucleic Acids Res., 47, 2019
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6RVZ
 | | Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate | | 分子名称: | ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ... | | 著者 | Kroupova, A, Jinek, M. | | 登録日 | 2019-06-03 | | 公開日 | 2020-05-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Science, 369, 2020
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