1PCP
 
 | | SOLUTION STRUCTURE OF A TREFOIL-MOTIF-CONTAINING CELL GROWTH FACTOR, PORCINE SPASMOLYTIC PROTEIN | | 分子名称: | PORCINE SPASMOLYTIC PROTEIN | | 著者 | Carr, M.D, Bauer, C.J, Gradwell, M.J, Feeney, J. | | 登録日 | 1993-02-04 | | 公開日 | 1994-05-31 | | 最終更新日 | 2017-11-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein.
Proc.Natl.Acad.Sci.USA, 91, 1994
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1NYO
 | | Solution structure of the antigenic TB protein MPT70/MPB70 | | 分子名称: | Immunogenic protein MPT70 | | 著者 | Bloemink, M.J, Dentten, E, Hewinson, R.G, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2003-02-13 | | 公開日 | 2003-08-19 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease
J.Biol.Chem., 278, 2003
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1A5J
 | | CHICKEN B-MYB DNA BINDING DOMAIN, REPEAT 2 AND REPEAT3, NMR, 32 STRUCTURES | | 分子名称: | B-MYB | | 著者 | Mcintosh, P.B, Carr, M.D, Wollborn, U, Frenkiel, T.A, Feeney, J, Mccormick, J.E, Klempnauer, K.H. | | 登録日 | 1998-02-16 | | 公開日 | 1998-07-01 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the B-Myb DNA-binding domain: a possible role for conformational instability of the protein in DNA binding and control of gene expression.
Biochemistry, 37, 1998
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5O57
 | | Solution Structure of the N-terminal Region of Dkk4 | | 分子名称: | Dickkopf-related protein 4 | | 著者 | Waters, L.C, Patel, S, Barkell, A.M, Muskett, F.W, Robinson, M.K, Holdsworth, G, Carr, M.D. | | 登録日 | 2017-06-01 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293, 2018
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7OW1
 | | Crystal Structure of TAP01 in complex with amyloid beta peptide | | 分子名称: | Amyloid-beta precursor protein, CITRATE ANION, TAP01 family antibody heavy chain, ... | | 著者 | Hall, G, Cowan, R, Carr, M.D. | | 登録日 | 2021-06-16 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
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7OXN
 | | Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide | | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta precursor protein, TAP01 family antibody heavy chain, ... | | 著者 | Hall, G, Cowan, R, Carr, M.D. | | 登録日 | 2021-06-22 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
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2TMP
 | | N-TERMINAL DOMAIN OF TISSUE INHIBITOR OF METALLOPROTEINASE-2 (N-TIMP-2), NMR, 49 STRUCTURES | | 分子名称: | TISSUE INHIBITOR OF METALLOPROTEINASES-2 | | 著者 | Muskett, F.W, Frenkiel, T.A, Feeney, J, Freedman, R.B, Carr, M.D, Williamson, R.A. | | 登録日 | 1998-05-26 | | 公開日 | 1998-12-09 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3.
J.Biol.Chem., 273, 1998
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1WA8
 | | Solution Structure of the CFP-10.ESAT-6 Complex. Major Virulence Determinants of Pathogenic Mycobacteria | | 分子名称: | 6 KDA EARLY SECRETORY ANTIGENIC TARGET (ESAT-6), ESAT-6 LIKE PROTEIN ESXB | | 著者 | Renshaw, P.S, Lightbody, K.L, Veverka, V, Muskett, F.W, Kelly, G, Frenkiel, T.A, Gordon, S.V, Hewinson, R.G, Burke, B, Norman, J, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2004-10-25 | | 公開日 | 2005-06-27 | | 最終更新日 | 2019-08-21 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Function of the Complex Formed by the Tuberculosis Virulence Factors Cfp-10 and Esat-6
Embo J., 24, 2005
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2HM8
 | | Solution Structure of the C-terminal MA-3 domain of Pdcd4 | | 分子名称: | Pdcd4 C-terminal MA-3 domain | | 著者 | Waters, L.C, Veverka, V, Bohm, M, Muskett, F.W, Choong, P.T, Klempnauer, K.H, Carr, M.D. | | 登録日 | 2006-07-11 | | 公開日 | 2007-02-20 | | 最終更新日 | 2022-03-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A
Oncogene, 26, 2007
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2KH2
 | | Solution structure of a scFv-IL-1B complex | | 分子名称: | Interleukin-1 beta, scFv | | 著者 | Wilkinson, I.C, Hall, C.J, Veverka, V, Muskett, F.W, Stephens, P.E, Taylor, R.J, Henry, A.J, Carr, M.D. | | 登録日 | 2009-03-23 | | 公開日 | 2009-09-08 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284, 2009
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2K8P
 | | Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation | | 分子名称: | Sclerostin | | 著者 | Veverka, V, Henry, A.J, Slocombe, P.M, Ventom, A, Mulloy, B, Muskett, F.W, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, R.J, Robinson, M.K, Carr, M.D. | | 登録日 | 2008-09-18 | | 公開日 | 2009-02-17 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
J.Biol.Chem., 284, 2009
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2L3Y
 | | Solution structure of mouse IL-6 | | 分子名称: | Interleukin-6 | | 著者 | Veverka, V, Redpath, N.T, Carrington, B, Muskett, F.W, Taylor, R.J, Henry, A.J, Carr, M.D. | | 登録日 | 2010-09-25 | | 公開日 | 2011-09-28 | | 最終更新日 | 2013-01-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
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2KZT
 | | Structure of the Tandem MA-3 Region of Pdcd4 | | 分子名称: | Programmed cell death protein 4 | | 著者 | Waters, L.C, Strong, S.L, Oka, O, Muskett, F.W, Veverka, V, Banerjee, S, Schmedt, T, Henry, A.J, Klempnauer, K.H, Carr, M.D. | | 登録日 | 2010-06-24 | | 公開日 | 2011-03-16 | | 最終更新日 | 2011-11-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor
J.Biol.Chem., 286, 2011
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2M4V
 | | Mycobacterium tuberculosis RNA polymerase binding protein A (RbpA) and its interactions with sigma factors | | 分子名称: | Putative uncharacterized protein | | 著者 | Bortoluzzi, A, Muskett, F.W, Waters, L.C, Addis, P.W, Rieck, B, Munder, T, Schleier, S, Forti, F, Ghisotti, D, Carr, M.D, O'Hare, H.M. | | 登録日 | 2013-02-11 | | 公開日 | 2013-04-17 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
J.Biol.Chem., 288, 2013
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2M2D
 | | Human programmed cell death 1 receptor | | 分子名称: | Programmed cell death protein 1 | | 著者 | Veverka, V, Cheng, X, Waters, L.C, Muskett, F.W, Morgan, S, Lesley, A, Griffiths, M, Stubberfield, C, Griffin, R, Henry, A.J, Robinson, M.K, Jansson, A, Ladbury, J.E, Ikemizu, S, Davis, S.J, Carr, M.D. | | 登録日 | 2012-12-18 | | 公開日 | 2013-02-27 | | 最終更新日 | 2013-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
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2NPU
 | | The solution structure of the rapamycin-binding domain of mTOR (FRB) | | 分子名称: | FKBP12-rapamycin complex-associated protein | | 著者 | Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D. | | 登録日 | 2006-10-30 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
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7BNV
 | | Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-300 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, Light Chain, ... | | 著者 | Hall, G, Cowan, R, Carr, M. | | 登録日 | 2021-01-22 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
Front Immunol, 12, 2021
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8B3K
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8BB7
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8BF4
 | | Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 and VHH14 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Cowan, R, Hall, G, Carr, M. | | 登録日 | 2022-10-24 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling.
J.Biol.Chem., 299, 2023
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7NP1
 | | Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoblobulin light chain, Immunoglobulin gamma-1 heavy chain, ... | | 著者 | Hall, G, Cowan, R, Carr, M. | | 登録日 | 2021-02-26 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
Front Immunol, 12, 2021
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1E9T
 | | High resolution solution structure of human intestinal trefoil factor | | 分子名称: | INTESTINAL TREFOIL FACTOR | | 著者 | Lemercinier, X, Muskett, F, Cheeseman, B, McIntosh, P, Carr, M. | | 登録日 | 2000-10-26 | | 公開日 | 2000-12-08 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High-Resolution Solution Structure of Human Intestinal Trefoil Factor and Functional Insights from Detailed Structural Comparisons with the Other Members of the Trefoil Family of Mammalian Cell Motility Factors
Biochemistry, 40, 2001
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6SS4
 | | Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021181 | | 分子名称: | Arginase-2, mitochondrial, Fab C0021181 heavy chain (IgG1), ... | | 著者 | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | | 登録日 | 2019-09-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mabs, 12
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6SS2
 | | Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021158 | | 分子名称: | Arginase-2, mitochondrial, Fab C0021158 heavy chain (IgG1), ... | | 著者 | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | | 登録日 | 2019-09-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mabs, 12
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6SS5
 | | Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0020187 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | | 登録日 | 2019-09-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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