1ZAP
 
 | | SECRETED ASPARTIC PROTEASE FROM C. ALBICANS | | 分子名称: | N-ethyl-N-[(4-methylpiperazin-1-yl)carbonyl]-D-phenylalanyl-N-[(1S,2S,4R)-4-(butylcarbamoyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]-L-norleucinamide, SECRETED ASPARTIC PROTEINASE, ZINC ION | | 著者 | Abad-Zapatero, C, Muchmore, S.W. | | 登録日 | 1996-01-16 | | 公開日 | 1997-04-21 | | 最終更新日 | 2012-01-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents.
Protein Sci., 5, 1996
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8LDH
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6LDH
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3PEP
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2NO3
 | | Novel 4-anilinopyrimidines as potent JNK1 Inhibitors | | 分子名称: | 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE, C-JUN-AMINO-TERMINAL KINASE-INTERACTING protein 1, Mitogen-activated protein kinase 8, ... | | 著者 | Abad-Zapatero, C. | | 登録日 | 2006-10-24 | | 公開日 | 2007-04-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
Bioorg.Med.Chem.Lett., 17, 2007
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6UCR
 | | Structure of ClpC1-NTD L92S L96P | | 分子名称: | ACETATE ION, Negative regulator of genetic competence ClpC/mecB | | 著者 | Abad-Zapatero, C, Wolf, N.M. | | 登録日 | 2019-09-17 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions.
Acta Crystallogr D Struct Biol, 76, 2020
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8G5W
 | | Structure of the Class II Fructose-1,6-Bisphophatase from Francisella tularensis complexed with native metal cofactor Mn++ | | 分子名称: | Fructose-1,6-bisphosphatase, GLYCEROL, MANGANESE (II) ION | | 著者 | Abad-Zapatero, C, Selezneva, A.I. | | 登録日 | 2023-02-14 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-07-05 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
Plos One, 18, 2023
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8G5X
 | | Structure of the Class II Fructose-1,6-Bisphophatase from Francisella tularensis complexed with native metal cofactor Mn++ and substrate Fructose-1,6-Bisphosphate | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase, GLYCEROL, ... | | 著者 | Abad-Zapatero, C, Selezneva, A.I. | | 登録日 | 2023-02-14 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-07-05 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
Plos One, 18, 2023
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6CN8
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7TXB
 | | Structure of the Class II Fructose-1,6-Bisphophatase from Mycobacterium tuberculosis complexed with substrate F1,6BP | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase class 2, GLYCEROL, ... | | 著者 | Abad-Zapatero, C, Selezneva, A.I, Gutka, H.J. | | 登録日 | 2022-02-08 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.71 Å) | | 主引用文献 | New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
Plos One, 18, 2023
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7TXA
 | | Structure of the Class II Fructose-1,6-Bisphophatase from Francisella tularensis complexed with native metal cofactor Mn++ and product F6P | | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase, MANGANESE (II) ION | | 著者 | Abad-Zapatero, C, Selezneva, A.I. | | 登録日 | 2022-02-08 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
Plos One, 18, 2023
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7TXG
 | | Structure of the Class II Fructose-1,6-Bisphosphatase from Francisella tularensis with native Mn++ divalent cation and partially occupied product F6P | | 分子名称: | Fructose-1,6-bisphosphatase, GLYCEROL, MANGANESE (II) ION, ... | | 著者 | Abad-Zapatero, C, Selezneva, A.I, Harding, L.N.M, Movahedzadeh, F. | | 登録日 | 2022-02-09 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
Plos One, 18, 2023
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7JS3
 | | Structure of the Class II Fructose-1,6-Bisphophatase from Francisella tularensis | | 分子名称: | Fructose-1,6-bisphosphatase, GLYCEROL, MAGNESIUM ION | | 著者 | Abad-Zapatero, C, Wolf, N.M, Movahedzadeh, F, Gutka, H, Selezneva, A. | | 登録日 | 2020-08-13 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and biochemical characterization of the class II fructose-1,6-bisphosphatase from Francisella tularensis.
Acta Crystallogr.,Sect.F, 76, 2020
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6PBA
 | | Structure of ClpC1-NTD | | 分子名称: | ATP-dependent Clp protease ATP-binding subunit ClpC1 | | 著者 | Abad-Zapatero, C, Wolf, N.M. | | 登録日 | 2019-06-13 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions.
Acta Crystallogr D Struct Biol, 76, 2020
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6PBQ
 | | Structure of ClpC1-NTD | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ATP-dependent Clp protease ATP-binding subunit ClpC1, PHOSPHATE ION | | 著者 | Abad-Zapatero, C, Wolf, N.M. | | 登録日 | 2019-06-14 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions.
Acta Crystallogr D Struct Biol, 76, 2020
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2H96
 | | Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors | | 分子名称: | 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE, C-jun-amino-terminal kinase-interacting protein 1, GLYCEROL, ... | | 著者 | Abad-Zapatero, C. | | 登録日 | 2006-06-09 | | 公開日 | 2006-07-25 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
J.Med.Chem., 49, 2006
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6PBS
 | | Structure of ClpC1-NTD in complex with Ecumicin | | 分子名称: | ACETATE ION, ATP-dependent Clp protease ATP-binding subunit ClpC1, ecumicin | | 著者 | Abad-Zapatero, C, Wolf, N.M. | | 登録日 | 2019-06-14 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions.
Acta Crystallogr D Struct Biol, 76, 2020
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2FIE
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2FIX
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2FHY
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3O17
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3O2M
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2GMX
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6AYY
 | | Crystal structure of Apo fructose-1,6-bisphosphatase from Mycobacterium tuberculosis | | 分子名称: | CITRIC ACID, Fructose-1,6-bisphosphatase class 2, GLYCEROL, ... | | 著者 | Abad-Zapatero, C, Wolf, N, Gutka, H.J, Movahedzadeh, F. | | 登録日 | 2017-09-08 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | Structures of the Mycobacterium tuberculosis GlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition.
Acta Crystallogr D Struct Biol, 74, 2018
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6AYU
 | | Crystal structure of fructose-1,6-bisphosphatase T84S from Mycobacterium tuberculosis | | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase class 2, GLYCEROL, ... | | 著者 | Abad-Zapatero, C, Wolf, N, Gutka, H.J, Movahedzadeh, F. | | 登録日 | 2017-09-08 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of the Mycobacterium tuberculosis GlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition.
Acta Crystallogr D Struct Biol, 74, 2018
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