2FHY

Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor

Summary for 2FHY

Entry DOI	10.2210/pdb2fhy/pdb
Related	2FIE 2FIX
Descriptor	Fructose-1,6-bisphosphatase 1, MAGNESIUM ION, 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE (3 entities in total)
Functional Keywords	allosteric inhibitors human fbpase, benzoxazole, intersubunit allosteric inhibition of human fpbase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	165587.29
Authors	Abad-Zapatero, C. (deposition date: 2005-12-27, release date: 2006-02-21, Last modification date: 2024-02-14)
Primary citation	von Geldern, T.W.,Lai, C.,Gum, R.J.,Daly, M.,Sun, C.,Fry, E.H.,Abad-Zapatero, C. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. Bioorg.Med.Chem.Lett., 16:1811-1815, 2006 Cited by PubMed Abstract: We have identified benzoxazole benzenesulfonamide 1 as a novel allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). X-ray crystallographic and biological studies of 1 indicate a distinct binding mode that recapitulates features of several previously reported FBPase-1 inhibitor classes. PubMed: 16442285 DOI: 10.1016/j.bmcl.2006.01.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation