8G5X

Structure of the Class II Fructose-1,6-Bisphophatase from Francisella tularensis complexed with native metal cofactor Mn++ and substrate Fructose-1,6-Bisphosphate

Summary for 8G5X

Entry DOI	10.2210/pdb8g5x/pdb
Related	7js3
Descriptor	Fructose-1,6-bisphosphatase, GLYCEROL, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	class ii fbpases; fructose-1, 6-bisphosphatase; francisella tularensis; mycobacterium tuberculosis; gluconeogenesis; antibiotic targets, hydrolase, hydrolase-product complex
Biological source	Francisella cf. tularensis subsp. novicida 3523
Total number of polymer chains	4
Total formula weight	149869.34
Authors	Abad-Zapatero, C.,Selezneva, A.I. (deposition date: 2023-02-14, release date: 2023-06-28, Last modification date: 2023-07-05)
Primary citation	Selezneva, A.I.,Harding, L.N.M.,Gutka, H.J.,Movahedzadeh, F.,Abad-Zapatero, C. New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class. Plos One, 18:e0274723-e0274723, 2023 Cited by PubMed: 37352301 DOI: 10.1371/journal.pone.0274723 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation