6M2B
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416 | Descriptor: | 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Li, H. | Deposit date: | 2020-02-27 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell, 11, 2020
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5YU9
| Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib | Descriptor: | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, CHLORIDE ION, Epidermal growth factor receptor | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2017-11-21 | Release date: | 2017-12-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation. Oncotarget, 7, 2016
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7EOD
| MITF HLHLZ Delta AKE | Descriptor: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | Authors: | Li, P, Liu, Z, Fang, P, Wang, J. | Deposit date: | 2021-04-22 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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8BS9
| Structure of USP36 in complex with Ubiquitin-PA | Descriptor: | Polyubiquitin-B, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 36, ... | Authors: | O'Dea, R, Gersch, M. | Deposit date: | 2022-11-24 | Release date: | 2023-07-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nat.Chem.Biol., 19, 2023
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8BS3
| Structure of USP36 in complex with Fubi-PA | Descriptor: | 40S ribosomal protein S30, Ubiquitin carboxyl-terminal hydrolase 36, ZINC ION, ... | Authors: | O'Dea, R, Gersch, M. | Deposit date: | 2022-11-24 | Release date: | 2023-07-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nat.Chem.Biol., 19, 2023
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8BRA
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8BRB
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5HYZ
| Crystal Structure of SCL7 in Oryza sativa | Descriptor: | GRAS family transcription factor containing protein, expressed | Authors: | Wu, Y, Li, S, Zhao, Y, Sun, L. | Deposit date: | 2016-02-02 | Release date: | 2016-04-27 | Last modified: | 2016-06-29 | Method: | X-RAY DIFFRACTION (1.822 Å) | Cite: | Crystal Structure of the GRAS Domain of SCARECROW-LIKE7 in Oryza sativa. Plant Cell, 28, 2016
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2P3U
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2P3T
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5XGV
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7D32
| The TBA-Pb2+ complex in P41212 space group | Descriptor: | DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3'), LEAD (II) ION | Authors: | Liu, H.H, Gao, Y.Q, Sheng, J, Gan, J.H. | Deposit date: | 2020-09-18 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.707 Å) | Cite: | Structure-guided development of Pb 2+ -binding DNA aptamers. Sci Rep, 12, 2022
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7D31
| The TBA-Pb2+ complex in P41212 space group | Descriptor: | DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3'), LEAD (II) ION | Authors: | Liu, H.H, Gao, Y.Q, Sheng, J, Gan, J.H. | Deposit date: | 2020-09-18 | Release date: | 2021-09-22 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.396 Å) | Cite: | Structure-guided development of Pb 2+ -binding DNA aptamers. Sci Rep, 12, 2022
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7D33
| The Pb2+ complexed structure of TBA G8C mutant | Descriptor: | DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*CP*TP*GP*GP*TP*TP*GP*G)-3'), LEAD (II) ION | Authors: | Liu, H.H, Gao, Y.Q, Sheng, J, Gan, J.H. | Deposit date: | 2020-09-18 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.117 Å) | Cite: | Structure-guided development of Pb 2+ -binding DNA aptamers. Sci Rep, 12, 2022
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7E8O
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7E8J
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7E8K
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8Y0R
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8Y0Q
| Complex of FMDV O/18074 and inter-serotype broadly neutralizing antibodies pOA-2 | Descriptor: | VP1 of capsid protein, VP2 of capsid protein, VP3 of capsid protein, ... | Authors: | Wu, S, Lei, D. | Deposit date: | 2024-01-23 | Release date: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.44 Å) | Cite: | Discovery, evolution and recognizing antigenic structures of cross-serotype broadly neutralizing antibodies from porcine B-cell repertoires against foot-and-mouth disease virus To Be Published
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4CKR
| Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1 | Descriptor: | 1,2-ETHANEDIOL, 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide, EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 | Authors: | Canning, P, Elkins, J.M, Goubin, S, Mahajan, P, Krojer, T, Newman, J.A, Dixon-Clarke, S, Chaikuad, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | Deposit date: | 2014-01-07 | Release date: | 2014-01-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor. Acs Chem.Biol., 8, 2013
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6WIN
| Type 6 secretion amidase effector 2 (Tae2) | Descriptor: | Type 6 secretion amidase effector 2 | Authors: | Chou, S, Radkov, A.D. | Deposit date: | 2020-04-10 | Release date: | 2020-04-22 | Last modified: | 2021-05-05 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin. Cell, 183, 2020
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2I7B
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1QA0
| BOVINE TRYPSIN 2-AMINOBENZIMIDAZOLE COMPLEX | Descriptor: | 2H-BENZOIMIDAZOL-2-YLAMINE, CALCIUM ION, TRYPSIN | Authors: | Whitlow, M. | Deposit date: | 1999-04-09 | Release date: | 2000-04-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin. Acta Crystallogr.,Sect.D, 55, 1999
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1QB6
| BOVINE TRYPSIN 3,3'-[3,5-DIFLUORO-4-METHYL-2, 6-PYRIDINEDIYLBIS(OXY)]BIS(BENZENECARBOXIMIDAMIDE) (ZK-805623) COMPLEX | Descriptor: | 3,3'-[3,5-DIFLUORO-4-METHYL-2,6-PYRIDYLENEBIS(OXY)]-BIS(BENZENECARBOXIMIDAMIDE), CALCIUM ION, POTASSIUM ION, ... | Authors: | Whitlow, M. | Deposit date: | 1999-04-29 | Release date: | 2000-04-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin. Acta Crystallogr.,Sect.D, 55, 1999
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1QB1
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