2I7B

Structure of the naturally occuring mutant of human ABO(H) Blood group B glycosyltransferase: GTB/A268T

Summary for 2I7B

Entry DOI	10.2210/pdb2i7b/pdb
Descriptor	alpha 1-3-galactosyltransferase, MERCURY (II) ION (3 entities in total)
Functional Keywords	glycosyltransferase, blood group, abo allele, hybrid allele, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34841.66
Authors	Letts, J.A.,Evans, S.V. (deposition date: 2006-08-30, release date: 2007-05-22, Last modification date: 2023-08-30)
Primary citation	Hosseini-Maaf, B.,Letts, J.A.,Persson, M.,Smart, E.,Lepennec, P.Y.,Hustinx, H.,Zhao, Z.,Palcic, M.M.,Evans, S.V.,Chester, M.A.,Olsson, M.L. Structural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferase. Transfusion, 47:864-875, 2007 Cited by PubMed Abstract: Four amino-acid-changing polymorphisms differentiate the blood group A and B alleles. Multiple missense mutations are associated with weak expression of A and B antigens but the structural changes causing subgroups have not been studied. PubMed: 17465952 DOI: 10.1111/j.1537-2995.2007.01203.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation