2P3U

Crystal structure of human factor XA complexed with 3-chloro-N-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1H-imidazol-2-yl)methyl]thiophene-2-carboxamide {Pfizer 320663}

Summary for 2P3U

• Entry DOI: 10.2210/pdb2p3u/pdb
• Related: 1EZQ 1F0R 1F0S 1FJS 1MQ5 1MQ6 2p3t
• Descriptor: Coagulation factor X, CALCIUM ION, 3-CHLORO-N-(4-CHLORO-2-{[(5-CHLOROPYRIDIN-2-YL)AMINO]CARBONYL}-6-METHOXYPHENYL)-4-[(1-METHYL-1H-IMIDAZOL-2-YL)METHYL]THIOPHENE-2-CARBOXAMIDE, ... (5 entities in total)
• Functional Keywords: protein inhibitor complex, coagulation cofactor, protease, blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32566.24

Authors

Adler, M.,Whitlow, M. (deposition date: 2007-03-09, release date: 2007-09-11, Last modification date: 2023-08-30)

• Primary citation: Crystal Structures of Two Potent Nonamidine Inhibitors Bound to Factor Xa; Biochemistry, 41:15514-15523, 2002

Experimental method

X-RAY DIFFRACTION (1.62 Å)