6KBE
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![BU of 6kbe by Molmil](/molmil-images/mine/6kbe) | Structure of Deubiquitinase | Descriptor: | Polyubiquitin-C, Ubiquitin thioesterase | Authors: | Lu, L.N, Liu, L, Wang, F. | Deposit date: | 2019-06-24 | Release date: | 2020-06-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.339 Å) | Cite: | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains Nat Commun, 13, 2022
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6VII
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6VPR
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2OUH
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![BU of 2ouh by Molmil](/molmil-images/mine/2ouh) | Crystal structure of the Thrombospondin-1 N-terminal domain in complex with fractionated Heparin DP10 | Descriptor: | SULFATE ION, Thrombospondin-1 | Authors: | Tan, K, Joachimiak, A, Wang, J, Lawler, J. | Deposit date: | 2007-02-11 | Release date: | 2008-01-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain. J.Biol.Chem., 283, 2008
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4QO8
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![BU of 4qo8 by Molmil](/molmil-images/mine/4qo8) | Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 104 | Descriptor: | (5S)-2-[(2-chlorophenyl)sulfanyl]-5-(2,6-dichlorophenyl)-3-hydroxycyclohex-2-en-1-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2014-06-19 | Release date: | 2014-07-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 24, 2014
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4QO7
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5GUF
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8JHQ
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![BU of 8jhq by Molmil](/molmil-images/mine/8jhq) | Cryo-EM structure of human S1P transporter SPNS2 bound with S1P | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2,GlgA glycogen synthase | Authors: | Pang, B, Yu, L.Y, Ren, R.B. | Deposit date: | 2023-05-25 | Release date: | 2024-01-10 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport. Cell Res., 34, 2024
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8JHR
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![BU of 8jhr by Molmil](/molmil-images/mine/8jhr) | Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d | Descriptor: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2 | Authors: | Pang, B, Yu, L.Y, Ren, R.B. | Deposit date: | 2023-05-25 | Release date: | 2024-01-10 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport. Cell Res., 34, 2024
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6K4V
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![BU of 6k4v by Molmil](/molmil-images/mine/6k4v) | The solution structure of the smart chimeric peptide G6 | Descriptor: | smart chimeric peptide G6 | Authors: | Wang, J.H, Liu, X.H. | Deposit date: | 2019-05-27 | Release date: | 2019-06-12 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Development of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli. Commun Biol, 3, 2020
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6K8I
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![BU of 6k8i by Molmil](/molmil-images/mine/6k8i) | Crystal structure of Arabidopsis thaliana CRY2 | Descriptor: | Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Ma, L, Wang, X, Guan, Z, Yin, P. | Deposit date: | 2019-06-12 | Release date: | 2020-05-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.697 Å) | Cite: | Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. Nat.Struct.Mol.Biol., 27, 2020
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6KYB
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![BU of 6kyb by Molmil](/molmil-images/mine/6kyb) | Crystal structure of Atg18 from Saccharomyces cerevisiae | Descriptor: | Autophagy-related protein 18 | Authors: | Tang, D, Lei, Y, Liao, G, Chen, Q, Xu, L, Lu, K, Qi, S. | Deposit date: | 2019-09-17 | Release date: | 2020-09-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The crystal structure of Atg18 reveals a new binding site for Atg2 in Saccharomyces cerevisiae. Cell.Mol.Life Sci., 78, 2021
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6LGW
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![BU of 6lgw by Molmil](/molmil-images/mine/6lgw) | Structure of Rabies virus glycoprotein in complex with neutralizing antibody 523-11 at acidic pH | Descriptor: | Glycoprotein, scFv 523-11 | Authors: | Yang, F.L, Lin, S, Ye, F, Yang, J, Qi, J.X, Chen, Z.J, Lin, X, Wang, J.C, Yue, D, Cheng, Y.W, Chen, Z.M, Chen, H, You, Y, Zhang, Z.L, Yang, Y, Yang, M, Sun, H.L, Li, Y.H, Cao, Y, Yang, S.Y, Wei, Y.Q, Gao, G.F, Lu, G.W. | Deposit date: | 2019-12-06 | Release date: | 2020-02-19 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9037 Å) | Cite: | Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody. Cell Host Microbe, 27, 2020
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6LGX
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![BU of 6lgx by Molmil](/molmil-images/mine/6lgx) | Structure of Rabies virus glycoprotein at basic pH | Descriptor: | Glycoprotein,Glycoprotein,Glycoprotein | Authors: | Yang, F.L, Lin, S, Ye, F, Yang, J, Qi, J.X, Chen, Z.J, Lin, X, Wang, J.C, Yue, D, Cheng, Y.W, Chen, Z.M, Chen, H, You, Y, Zhang, Z.L, Yang, Y, Yang, M, Sun, H.L, Li, Y.H, Cao, Y, Yang, S.Y, Wei, Y.Q, Gao, G.F, Lu, G.W. | Deposit date: | 2019-12-06 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.097 Å) | Cite: | Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody. Cell Host Microbe, 27, 2020
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8FZ5
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![BU of 8fz5 by Molmil](/molmil-images/mine/8fz5) | The PI31-free Bovine 20S proteasome | Descriptor: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | Authors: | Hsu, H.-C, Li, H. | Deposit date: | 2023-01-27 | Release date: | 2023-07-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.23 Å) | Cite: | Eta igh-resolution structure of mammalian PI31-20S proteasome complex reveals mechanism of proteasome inhibition. J.Biol.Chem., 299, 2023
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5FDL
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![BU of 5fdl by Molmil](/molmil-images/mine/5fdl) | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899 | Descriptor: | P51 Reverse transcriptase, P66 Reverse transcriptase, methyl (R)-(2-carbamoyl-5-chloro-1H-indol-3-yl)[3-(2-cyanoethyl)-5-methylphenyl]phosphinate | Authors: | Dousson, C.B, Alexandre, F.-R, Convard, T, Fisher, M, Lamers, M.B.A.C, Leonard, P.M. | Deposit date: | 2015-12-16 | Release date: | 2016-02-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor. J.Med.Chem., 59, 2016
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4TZ7
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![BU of 4tz7 by Molmil](/molmil-images/mine/4tz7) | Crystal structure of type I phosphatidylinositol 4-phosphate 5-kinase alpha from Zebrafish | Descriptor: | Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | Authors: | Hu, J, Qin, Y, Wang, J, Li, L, Wu, D, Ha, Y. | Deposit date: | 2014-07-09 | Release date: | 2015-09-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.31 Å) | Cite: | Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled. Nat Commun, 6, 2015
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3A2O
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![BU of 3a2o by Molmil](/molmil-images/mine/3a2o) | Crystal Structure of HIV-1 Protease Complexed with KNI-1689 | Descriptor: | (4R)-3-[(2S,3S)-3-{[(4-amino-2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylprop -2-en-1-yl)-1,3-thiazolidine-4-carboxamide, GLYCEROL, PROTEASE | Authors: | Adachi, M, Tamada, T, Hidaka, K, Kimura, T, Kiso, Y, Kuroki, R. | Deposit date: | 2009-05-26 | Release date: | 2010-03-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (0.88 Å) | Cite: | Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket. J.Med.Chem., 52, 2009
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7YIM
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![BU of 7yim by Molmil](/molmil-images/mine/7yim) | Cryo-EM structure of human Alpha-fetoprotein | Descriptor: | Alpha-fetoprotein | Authors: | Liu, N, Liu, K, Wu, C, Liu, Z, Li, M, Wang, J, Wang, H.W. | Deposit date: | 2022-07-17 | Release date: | 2023-01-18 | Last modified: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Uniform thin ice on ultraflat graphene for high-resolution cryo-EM. Nat.Methods, 20, 2023
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4HCP
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8FZ6
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![BU of 8fz6 by Molmil](/molmil-images/mine/8fz6) | The human PI31 complexed with bovine 20S proteasome | Descriptor: | Proteasome inhibitor PI31 subunit, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | Authors: | Hsu, H.-C, Li, H. | Deposit date: | 2023-01-27 | Release date: | 2023-07-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Eta igh-resolution structure of mammalian PI31-20S proteasome complex reveals mechanism of proteasome inhibition. J.Biol.Chem., 299, 2023
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3QUY
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![BU of 3quy by Molmil](/molmil-images/mine/3quy) | Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex | Descriptor: | (2S,3R,4S,5R,6S)-6-[(2S,3S,4R)-2-(hexacosanoylamino)-3,4-dihydroxy-octadecoxy]-3,4,5-trihydroxy-N-(phenylmethyl)oxane-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, Y, Girardi, E, Yu, E.D, Zajonc, D.M. | Deposit date: | 2011-02-24 | Release date: | 2011-06-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis. Embo J., 30, 2011
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6K8K
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![BU of 6k8k by Molmil](/molmil-images/mine/6k8k) | Crystal structure of Arabidopsis thaliana BIC2-CRY2 complex | Descriptor: | ADENOSINE MONOPHOSPHATE, Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Wang, X, Ma, L, Guan, Z, Yin, P. | Deposit date: | 2019-06-12 | Release date: | 2020-05-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. Nat.Struct.Mol.Biol., 27, 2020
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7E2R
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![BU of 7e2r by Molmil](/molmil-images/mine/7e2r) | The ligand-free structure of Arabidopsis thaliana GUN4 | Descriptor: | Tetrapyrrole-binding protein, chloroplastic | Authors: | Liu, L, Hu, J. | Deposit date: | 2021-02-07 | Release date: | 2021-08-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis of bilin binding by the chlorophyll biosynthesis regulator GUN4. Protein Sci., 30, 2021
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5T5G
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![BU of 5t5g by Molmil](/molmil-images/mine/5t5g) | human SETD8 in complex with MS2177 | Descriptor: | 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION | Authors: | Yu, W, Tempel, W, Babault, N, Ma, A, Butler, K.V, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2016-08-30 | Release date: | 2016-09-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J. Med. Chem., 59, 2016
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