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Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade AE Strain 93TH057 gp120 Core
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Heavy chain of N6, ...
Authors:	Zhou, T, Kwong, P.D.
Deposit date:	2016-09-20
Release date:	2016-11-16
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity, 45, 2016

5TE7

Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade C Strain DU172.17 gp120 Core
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:	Zhou, T, Kwong, P.D.
Deposit date:	2016-09-20
Release date:	2016-11-16
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth. Immunity, 45, 2016

7UPY

An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Zhang, J, Luo, S, Kreutzberger, A, Kirchhausen, T, Chen, B, Haynes, B, Alt, F.
Deposit date:	2022-04-18
Release date:	2022-08-10
Last modified:	2024-02-21
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol, 7, 2022

7UPX

Three RBD-down state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment (local refinement of the RBD and Fab variable domains)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, SP1-77 Fab heavy chain, SP1-77 Fab light chain, ...
Authors:	Zhang, J, Luo, S, Kreutzberger, A, Kirchhausen, T, Chen, B, Haynes, B, Alt, F.
Deposit date:	2022-04-18
Release date:	2022-08-10
Last modified:	2023-08-23
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol, 7, 2022

7UPW

Three RBD-down state of SARS-CoV-2 D614G spike in complex with the SP1-77 neutralizing antibody Fab fragment
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Zhang, J, Luo, S, Kreutzberger, A, Kirchhausen, T, Chen, B, Haynes, B, Alt, F.
Deposit date:	2022-04-18
Release date:	2022-08-10
Last modified:	2023-08-23
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol, 7, 2022

7LWS

UK (B.1.1.7) SARS-CoV-2 S-GSAS-D614G variant spike protein in the 3-RBD-down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-06-30
Method:	ELECTRON MICROSCOPY (3.22 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity. Biorxiv, 2021

5F6H

Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque
Descriptor:	DH427 Antibody Heavy Chain, DH427 Antibody Light Chain
Authors:	Fera, D, Harrison, S.C.
Deposit date:	2015-12-06
Release date:	2016-01-13
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.66 Å)
Cite:	Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep, 14, 2016

5F6J

Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core
Descriptor:	DH427 Antibody Heavy Chain, DH427 Antibody Light Chain, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C
Authors:	Fera, D, Harrison, S.C.
Deposit date:	2015-12-06
Release date:	2016-01-13
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (6.63 Å)
Cite:	Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep, 14, 2016

5DD6

Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques
Descriptor:	ANTI-HIV ANTIBODY DH570.mut58 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570.mut58 FAB LIGHT CHAIN
Authors:	Nicely, N.I, Pemble IV, C.W, Haynes, B.F.
Deposit date:	2015-08-24
Release date:	2016-05-11
Last modified:	2019-12-11
Method:	X-RAY DIFFRACTION (1.699 Å)
Cite:	Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016

5DD3

Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques
Descriptor:	ANTI-HIV ANTIBODY DH570.4 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570.4 FAB LIGHT CHAIN
Authors:	Nicely, N.I, Pemble IV, C.W, Haynes, B.F.
Deposit date:	2015-08-24
Release date:	2016-05-11
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.797 Å)
Cite:	Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016

5DD5

Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques
Descriptor:	ANTI-HIV ANTIBODY DH570.9 FAB HEAVY CHAIN
Authors:	Nicely, N.I, Pemble IV, C.W, Haynes, B.F.
Deposit date:	2015-08-24
Release date:	2016-05-11
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016

5F6I

Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque
Descriptor:	DH428 Antibody Heavy Chain, DH428 Antibody Light Chain
Authors:	Fera, D, Harrison, S.C.
Deposit date:	2015-12-06
Release date:	2016-01-13
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep, 14, 2016

7BH8

3H4-Fab HLA-E-VL9 co-complex
Descriptor:	3H4 Fab heavy chain, 3H4 Fab light chain, Beta-2-microglobulin, ...
Authors:	Walters, L.C, Rozbesky, D.
Deposit date:	2021-01-10
Release date:	2022-04-13
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity. Commun Biol, 5, 2022

5IQ7

Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide.
Descriptor:	10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide
Authors:	Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D.
Deposit date:	2016-03-10
Release date:	2016-04-20
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (3.2869 Å)
Cite:	Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. J.Virol., 90, 2016

4DQO

Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109
Descriptor:	1FD6-V1V2 scaffold ZM109 HIV-1 strain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG16 Fab Heavy Chain, ...
Authors:	Pancera, M, McLellan, J.S, Kwong, P.D.
Deposit date:	2012-02-16
Release date:	2013-03-06
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.438 Å)
Cite:	Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nat.Struct.Mol.Biol., 20, 2013

8V1L

Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule
Descriptor:	N-[(2S)-2-fluoro-4,4-dimethylpentanoyl]-3-hydroxy-L-valyl-(betaS)-beta-methyl-L-phenylalanyl-D-alanyl-N-benzyl-N,O-dimethyl-L-homoserinamide, Ras GTPase-activating protein-binding protein 1
Authors:	Hughes, M.P, Taylor, J.P.
Deposit date:	2023-11-20
Release date:	2024-02-14
Method:	X-RAY DIFFRACTION (2.68 Å)
Cite:	Identification of small molecule inhibitors of G3BP-driven stress granule formation. J.Cell Biol., 223, 2024

2A6T

Crystal structure of S.pombe mRNA decapping enzyme Dcp2p
Descriptor:	SPAC19A8.12
Authors:	She, M, Chen, N, Song, H.
Deposit date:	2005-07-04
Release date:	2005-12-20
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe Nat.Struct.Mol.Biol., 13, 2006

4B6H

Structure of hDcp1a in complex with proline rich sequence of PNRC2
Descriptor:	MRNA-DECAPPING ENZYME 1A, PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR 2
Authors:	Lai, T, Song, H.
Deposit date:	2012-08-13
Release date:	2013-03-06
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural Basis of the Pnrc2-Mediated Link between Mrna Surveillance and Decapping. Structure, 20, 2012

3MCA

Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay
Descriptor:	Elongation factor 1 alpha-like protein, Protein dom34
Authors:	Chen, L, Song, H.
Deposit date:	2010-03-28
Release date:	2010-10-06
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.74 Å)
Cite:	Structure of the Dom34-Hbs1 complex and implications for no-go decay Nat.Struct.Mol.Biol., 17, 2010

2NNQ

Crystal structure of human adipocyte fatty acid binding protein in complex with ((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-3-biphenylyl)oxy)acetic acid
Descriptor:	((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC ACID, Fatty acid-binding protein, adipocyte, ...
Authors:	Jacobson, B.L.
Deposit date:	2006-10-24
Release date:	2007-06-12
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg.Med.Chem.Lett., 17, 2007

1XMM

Structure of human Dcps bound to m7GDP
Descriptor:	7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, N7-METHYL-GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
Authors:	Chen, N, Song, H.
Deposit date:	2004-10-04
Release date:	2005-03-22
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. J.Mol.Biol., 347, 2005

1XML

Structure of human Dcps
Descriptor:	PHOSPHATE ION, heat shock-like protein 1
Authors:	Chen, N, Song, H.
Deposit date:	2004-10-04
Release date:	2005-03-22
Last modified:	2024-05-29
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. J.Mol.Biol., 347, 2005

5IQZ

Crystal structure of N-terminal domain of Human SIRT7
Descriptor:	SIRT7 protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:	Thakur, K.G, Priyanka, A.
Deposit date:	2016-03-11
Release date:	2016-07-27
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.334 Å)
Cite:	Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture Proteins, 84, 2016

4N0A

Crystal structure of Lsm2-3-Pat1C complex from Saccharomyces cerevisiae
Descriptor:	DNA topoisomerase 2-associated protein PAT1, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3
Authors:	Wu, D.H.
Deposit date:	2013-10-01
Release date:	2013-12-04
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (3.15 Å)
Cite:	Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation Cell Res., 24, 2014

1S2M

Crystal Structure of the DEAD box protein Dhh1p
Descriptor:	Putative ATP-dependent RNA helicase DHH1
Authors:	Cheng, Z, Song, H.
Deposit date:	2004-01-09
Release date:	2005-03-01
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal structure and functional analysis of DEAD-box protein Dhh1p. Rna, 11, 2005

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