8V1L

Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule

Summary for 8V1L

• Entry DOI: 10.2210/pdb8v1l/pdb
• Descriptor: Ras GTPase-activating protein-binding protein 1, N-[(2S)-2-fluoro-4,4-dimethylpentanoyl]-3-hydroxy-L-valyl-(betaS)-beta-methyl-L-phenylalanyl-D-alanyl-N-benzyl-N,O-dimethyl-L-homoserinamide (3 entities in total)
• Functional Keywords: small molecule, complex, ntf2l, g3bp1 faz compound, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 99677.73

Authors

Hughes, M.P.,Taylor, J.P. (deposition date: 2023-11-20, release date: 2024-02-14)

• Primary citation: Freibaum, B.D.,Messing, J.,Nakamura, H.,Yurtsever, U.,Wu, J.,Kim, H.J.,Hixon, J.,Lemieux, R.M.,Duffner, J.,Huynh, W.,Wong, K.,White, M.,Lee, C.,Meyers, R.E.,Parker, R.,Taylor, J.P.; Identification of small molecule inhibitors of G3BP-driven stress granule formation.; J.Cell Biol., 223:-, 2024; PubMed: 38284934; DOI: 10.1083/jcb.202308083

Experimental method

X-RAY DIFFRACTION (2.68 Å)