2NNQ

Crystal structure of human adipocyte fatty acid binding protein in complex with ((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-3-biphenylyl)oxy)acetic acid

Summary for 2NNQ

Entry DOI	10.2210/pdb2nnq/pdb
Descriptor	Fatty acid-binding protein, adipocyte, SULFATE ION, ((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC ACID, ... (4 entities in total)
Functional Keywords	transport, lipid-binding, lipid transport
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15090
Total number of polymer chains	1
Total formula weight	15275.38
Authors	Jacobson, B.L. (deposition date: 2006-10-24, release date: 2007-06-12, Last modification date: 2024-04-03)
Primary citation	Sulsky, R.,Magnin, D.R.,Huang, Y.,Simpkins, L.,Taunk, P.,Patel, M.,Zhu, Y.,Stouch, T.R.,Bassolino-Klimas, D.,Parker, R.,Harrity, T.,Stoffel, R.,Taylor, D.S.,Lavoie, T.B.,Kish, K.,Jacobson, B.L.,Sheriff, S.,Adam, L.P.,Ewing, W.R.,Robl, J.A. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg.Med.Chem.Lett., 17:3511-3515, 2007 Cited by PubMed: 17502136 DOI: 10.1016/j.bmcl.2006.12.044 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation