2PQT
 
 | | Human N-acetyltransferase 1 | | Descriptor: | Arylamine N-acetyltransferase 1, CHLORIDE ION, UNKNOWN ATOM OR ION | | Authors: | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-05-02 | | Release date: | 2007-05-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural Basis of Substrate-binding Specificity of Human Arylamine N-Acetyltransferases.
J.Biol.Chem., 282, 2007
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2OGP
 | | Solution structure of the second PDZ domain of Par-3 | | Descriptor: | Partitioning-defective 3 homolog | | Authors: | Feng, W, Wu, H, Chen, J, Chan, L.-N, Zhang, M. | | Deposit date: | 2007-01-07 | | Release date: | 2007-12-25 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | PDZ domains of par-3 as potential phosphoinositide signaling integrators
Mol.Cell, 28, 2007
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2IJA
 | | Human N-acetyltransferase 1 F125S mutant | | Descriptor: | ACETAMIDE, Arylamine N-acetyltransferase 1, SODIUM ION, ... | | Authors: | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-09-29 | | Release date: | 2006-11-28 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.701 Å) | | Cite: | The Crystal Structure of Human N-acetyltransferase 1 mutant, F125S
To be Published
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2GIV
 | | Human MYST histone acetyltransferase 1 | | Descriptor: | ACETYL COENZYME *A, CHLORIDE ION, Probable histone acetyltransferase MYST1, ... | | Authors: | Min, J, Wu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-03-29 | | Release date: | 2006-04-11 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | The Crystal Structure of Human MYST histone acetyltransferase 1 in complex with acetylcoenzyme A
To be Published
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2B9E
 | | Human NSUN5 protein | | Descriptor: | NOL1/NOP2/Sun domain family, member 5 isoform 2, S-ADENOSYLMETHIONINE | | Authors: | Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2005-10-11 | | Release date: | 2005-10-18 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The Crystal Structure of Human NSUN5 protein in complex with
S-adenosyl-L-methionine
To be Published
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2AVD
 | | Crystal Structure of Human Catechol-O-methyltransferase domain containing 1 | | Descriptor: | Catechol-O-methyltransferase, S-ADENOSYLMETHIONINE | | Authors: | Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2005-08-29 | | Release date: | 2005-09-13 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Crystal Structure of Human Catechol-O-methyltransferase
domain containing 1 in complex with S-adenosyl-L-methionine
To be Published
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4U6V
 | | Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody | | Descriptor: | Alpha-hemolysin, Fab, antigen binding fragment, ... | | Authors: | Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F. | | Deposit date: | 2014-07-29 | | Release date: | 2014-09-17 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
J.Biol.Chem., 289, 2014
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5WCF
 | | Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) | | Descriptor: | (5R)-4-(5-bromofuran-2-carbonyl)-5-(4-fluorophenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Dong, A, Zeng, H, Hutch, A, Seitova, A, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-06-30 | | Release date: | 2017-08-02 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with MTLLE1441
to be published
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5WCI
 | | Human MYST histone acetyltransferase 1 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Histone acetyltransferase KAT8, ... | | Authors: | Dong, A, Zeng, H, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Zheng, Y.G, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-06-30 | | Release date: | 2017-07-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Human MYST histone acetyltransferase 1
to be published
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5WCG
 | | SET and MYND Domain Containing protein 2 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, N-lysine methyltransferase SMYD2, ... | | Authors: | Dong, A, Zeng, H, Walker, J.R, Hutch, A, Seitova, A, Tatlock, J, Kumpf, R, Owen, A, Taylor, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-06-30 | | Release date: | 2017-08-02 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | The crystal structure of SMYD2 in complex with compound MTF003
to be published
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6WM3
 | | Human V-ATPase in state 2 with SidK and ADP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, Renin receptor, ... | | Authors: | Wang, L, Wu, H, Fu, T.M. | | Deposit date: | 2020-04-20 | | Release date: | 2020-11-11 | | Last modified: | 2020-11-18 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
Mol.Cell, 80, 2020
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3M0A
 | | Crystal structure of TRAF2:cIAP2 complex | | Descriptor: | Baculoviral IAP repeat-containing protein 3, TNF receptor-associated factor 2, ZINC ION | | Authors: | Kabaleeswaran, V, Wu, H. | | Deposit date: | 2010-03-02 | | Release date: | 2010-04-28 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Mol.Cell, 38, 2010
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3MEK
 | | Crystal Structure of Human Histone-Lysine N-methyltransferase SMYD3 in Complex with S-adenosyl-L-methionine | | Descriptor: | S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ZINC ION | | Authors: | Lam, R, Dombrovski, L, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2010-03-31 | | Release date: | 2010-04-14 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of Human Histone-Lysine N-methyltransferase SMYD3 in Complex with S-adenosyl-L-methionine
To be Published
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3MOP
 | | The ternary Death Domain complex of MyD88, IRAK4, and IRAK2 | | Descriptor: | Interleukin-1 receptor-associated kinase 4, Interleukin-1 receptor-associated kinase-like 2, Myeloid differentiation primary response protein MyD88 | | Authors: | Lin, S.-C, Lo, Y.-C, Wu, H. | | Deposit date: | 2010-04-23 | | Release date: | 2010-06-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
Nature, 465, 2010
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6DLO
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6DLP
 | | Crystal structure of LRRK2 WD40 domain dimer | | Descriptor: | Leucine-rich repeat serine/threonine-protein kinase 2, PLATINUM (II) ION | | Authors: | Zhang, P, Ru, H, Wang, L, Wu, H. | | Deposit date: | 2018-06-02 | | Release date: | 2019-01-09 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Crystal structure of the WD40 domain dimer of LRRK2.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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4KFP
 | | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | | Descriptor: | 1,2-ETHANEDIOL, N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | | Authors: | Dragovich, P.S, Bair, K.W, Baumeister, T, Ho, Y, Liederer, B.M, Liu, X, O'Brien, T, Oeh, J, Sampath, D, Skelton, N, Wang, L, Wang, W, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X. | | Deposit date: | 2013-04-27 | | Release date: | 2013-08-14 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
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5L08
 | | Cryo-EM structure of Casp-8 tDED filament | | Descriptor: | Caspase-8 | | Authors: | Fu, T.M, Li, Y, Lu, A, Wu, H. | | Deposit date: | 2016-07-26 | | Release date: | 2016-11-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol.Cell, 64, 2016
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8SPB
 | | Caspase-4/Pro-IL-18 complex | | Descriptor: | Caspase-4 subunit p10, Caspase-4 subunit p20, Interleukin-18 | | Authors: | Pascal, D, Dong, Y, Wu, H, Jon, K. | | Deposit date: | 2023-05-02 | | Release date: | 2023-11-22 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into cytokine cleavage by inflammatory caspase-4.
Nature, 624, 2023
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8SV1
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4W6Q
 | | Glycosyltransferase C from Streptococcus agalactiae | | Descriptor: | SERINE, URIDINE-5'-DIPHOSPHATE, glucosyltransferase | | Authors: | Zhu, F, Zhang, H, Wu, H. | | Deposit date: | 2014-08-20 | | Release date: | 2015-07-15 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A conserved domain is crucial for acceptor substrate binding in a family of glucosyltransferases.
J.Bacteriol., 197, 2015
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4U97
 | | Crystal Structure of Asymmetric IRAK4 Dimer | | Descriptor: | Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION | | Authors: | Ferrao, R, Wu, H. | | Deposit date: | 2014-08-05 | | Release date: | 2014-09-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
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4U9A
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2LIT
 | | NMR Solution Structure of Yeast Iso-1-cytochrome c Mutant P71H in reduced states | | Descriptor: | Cytochrome c iso-1, HEME C | | Authors: | Lan, W, Wang, Z, Yang, Z, Zhu, J, Ying, T, Jiang, X, Zhang, X, Wu, H, Liu, M, Tan, X, Cao, C, Huang, Z.X. | | Deposit date: | 2011-08-31 | | Release date: | 2011-12-07 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
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2LIR
 | | NMR Solution Structure of Yeast Iso-1-cytochrome c Mutant P71H in oxidized states | | Descriptor: | Cytochrome c iso-1, HEME C | | Authors: | Lan, W, Wang, Z, Yang, Z, Zhu, J, Ying, T, Jiang, X, Zhang, X, Wu, H, Liu, M, Tan, X, Cao, C, Huang, Z.X. | | Deposit date: | 2011-08-31 | | Release date: | 2011-12-07 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
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