8EFO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8efo by Molmil](/molmil-images/mine/8efo) | PZM21-bound mu-opioid receptor-Gi complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | Deposit date: | 2022-09-08 | Release date: | 2022-11-09 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
|
|
8EFL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8efl by Molmil](/molmil-images/mine/8efl) | SR17018-bound mu-opioid receptor-Gi complex | Descriptor: | 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | Deposit date: | 2022-09-08 | Release date: | 2022-11-09 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
|
|
8EFQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8efq by Molmil](/molmil-images/mine/8efq) | DAMGO-bound mu-opioid receptor-Gi complex | Descriptor: | DAMGO, ETHANOLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | Deposit date: | 2022-09-08 | Release date: | 2022-11-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor. Cell, 185, 2022
|
|
5CJ3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cj3 by Molmil](/molmil-images/mine/5cj3) | Crystal structure of the zorbamycin binding protein (ZbmA) from Streptomyces flavoviridis with zorbamycin | Descriptor: | CHLORIDE ION, COPPER (II) ION, Zbm binding protein, ... | Authors: | Chang, C, Bigelow, L, Clancy, S, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Rudolf, J.D, Ma, M, Chang, C.-Y, Lohman, J.R, Yang, D, Shen, B, Enzyme Discovery for Natural Product Biosynthesis, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | Deposit date: | 2015-07-13 | Release date: | 2015-07-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6499 Å) | Cite: | Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. Biochemistry, 54, 2015
|
|
3WY0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3wy0 by Molmil](/molmil-images/mine/3wy0) | The I375W mutant of CsyB complexed with CoA-SH | Descriptor: | COENZYME A, Putative uncharacterized protein csyB | Authors: | Mori, T, Yang, D, Matsui, T, Morita, H, Fujii, I, Abe, I. | Deposit date: | 2014-08-13 | Release date: | 2015-01-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural basis for the formation of acylalkylpyrones from two beta-ketoacyl units by the fungal type III polyketide synthase CsyB. J.Biol.Chem., 290, 2015
|
|
3WXY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3wxy by Molmil](/molmil-images/mine/3wxy) | Crystal structure of CsyB complexed with CoA-SH | Descriptor: | COENZYME A, Putative uncharacterized protein csyB | Authors: | Mori, T, Yang, D, Matsui, T, Morita, H, Fujii, I, Abe, I. | Deposit date: | 2014-08-13 | Release date: | 2015-01-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.706 Å) | Cite: | Structural basis for the formation of acylalkylpyrones from two beta-ketoacyl units by the fungal type III polyketide synthase CsyB. J.Biol.Chem., 290, 2015
|
|
1TN5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1tn5 by Molmil](/molmil-images/mine/1tn5) | Structure of bacterorhodopsin mutant K41P | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Yohannan, S, Yang, D, Faham, S, Boulting, G, Whitelegge, J, Bowie, J.U. | Deposit date: | 2004-06-11 | Release date: | 2004-10-19 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Proline substitutions are not easily accommodated in a membrane protein J.Mol.Biol., 341, 2004
|
|
1TN0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1tn0 by Molmil](/molmil-images/mine/1tn0) | Structure of bacterorhodopsin mutant A51P | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Yohannan, S, Yang, D, Faham, S, Boulting, G, Whitelegge, J, Bowie, J.U. | Deposit date: | 2004-06-11 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Proline substitutions are not easily accommodated in a membrane protein J.Mol.Biol., 341, 2004
|
|
3SQJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3sqj by Molmil](/molmil-images/mine/3sqj) | Recombinant human serum albumin from transgenic plant | Descriptor: | MYRISTIC ACID, Serum albumin | Authors: | He, Y, Yang, D. | Deposit date: | 2011-07-05 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Large-scale production of functional human serum albumin from transgenic rice seeds. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
7MYN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7myn by Molmil](/molmil-images/mine/7myn) | Cryo-EM Structure of p110alpha in complex with p85alpha | Descriptor: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K. | Deposit date: | 2021-05-21 | Release date: | 2021-11-10 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7MYO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7myo by Molmil](/molmil-images/mine/7myo) | Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719 | Descriptor: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K. | Deposit date: | 2021-05-21 | Release date: | 2021-11-10 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
3HAR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3har by Molmil](/molmil-images/mine/3har) | |
6W2C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w2c by Molmil](/molmil-images/mine/6w2c) | Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site | Descriptor: | 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, I-paroxetine, ... | Authors: | Coleman, J.A, Navratna, V, Yang, D. | Deposit date: | 2020-03-05 | Release date: | 2020-03-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (6.3 Å) | Cite: | Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Elife, 9, 2020
|
|
3HAO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hao by Molmil](/molmil-images/mine/3hao) | |
1M8A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1m8a by Molmil](/molmil-images/mine/1m8a) | Human MIP-3alpha/CCL20 | Descriptor: | ISOPROPYL ALCOHOL, Small inducible cytokine A20 | Authors: | Hoover, D.M, Boulegue, C, Yang, D, Oppenheim, J.J, Tucker, K, Lu, W, Lubkowski, J. | Deposit date: | 2002-07-24 | Release date: | 2002-07-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins J.Biol.Chem., 277, 2002
|
|
6V0L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6v0l by Molmil](/molmil-images/mine/6v0l) | PDGFR-b Promoter Forms a G-Vacancy Quadruplex that Can be Complemented by dGMP: Molecular Structure and Recognition of Guanine Derivatives and Metabolites | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*(3D1)P*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*GP*CP*GP*GP*GP*AP*CP*A)-3') | Authors: | Wang, K.B, Dickerhoff, J, Wu, G, Yang, D. | Deposit date: | 2019-11-18 | Release date: | 2020-03-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | PDGFR-beta Promoter Forms a Vacancy G-Quadruplex that Can Be Filled in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs. J.Am.Chem.Soc., 142, 2020
|
|
3HAQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3haq by Molmil](/molmil-images/mine/3haq) | Crystal structure of bacteriorhodopsin mutant I148A crystallized from bicelles | Descriptor: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Bacteriorhodopsin, DECANE, ... | Authors: | Joh, N.H, Yang, D, Bowie, J.U. | Deposit date: | 2009-05-02 | Release date: | 2009-09-22 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Similar energetic contributions of packing in the core of membrane and water-soluble proteins. J.Am.Chem.Soc., 131, 2009
|
|
3HAN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3han by Molmil](/molmil-images/mine/3han) | |
3HAS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3has by Molmil](/molmil-images/mine/3has) | Crystal structure of bacteriorhodopsin mutant L152A crystallized from bicelles | Descriptor: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Bacteriorhodopsin, DECANE, ... | Authors: | Joh, N.H, Yang, D, Bowie, J.U. | Deposit date: | 2009-05-02 | Release date: | 2009-09-22 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Similar energetic contributions of packing in the core of membrane and water-soluble proteins. J.Am.Chem.Soc., 131, 2009
|
|
3HAP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hap by Molmil](/molmil-images/mine/3hap) | Crystal structure of bacteriorhodopsin mutant L111A crystallized from bicelles | Descriptor: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Bacteriorhodopsin, DECANE, ... | Authors: | Joh, N.H, Yang, D, Bowie, J.U. | Deposit date: | 2009-05-02 | Release date: | 2009-09-22 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Similar energetic contributions of packing in the core of membrane and water-soluble proteins. J.Am.Chem.Soc., 131, 2009
|
|
1PXR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1pxr by Molmil](/molmil-images/mine/1pxr) | Structure of Pro50Ala mutant of Bacteriorhodopsin | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Faham, S, Yang, D, Bare, E, Yohannan, S, Whitelegge, J.P, Bowie, J.U. | Deposit date: | 2003-07-06 | Release date: | 2003-12-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Side-chain Contributions to Membrane Protein Structure and Stability. J.Mol.Biol., 335, 2004
|
|
1PY6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1py6 by Molmil](/molmil-images/mine/1py6) | Bacteriorhodopsin crystallized from bicells | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Faham, S, Yang, D, Bare, E, Yohannan, S, Whitelegge, J.P, Bowie, J.U. | Deposit date: | 2003-07-08 | Release date: | 2003-12-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Side-chain Contributions to Membrane Protein Structure and Stability. J.Mol.Biol., 335, 2004
|
|
1Q5I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1q5i by Molmil](/molmil-images/mine/1q5i) | Crystal structure of bacteriorhodopsin mutant P186A crystallized from bicelles | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Yohannan, S, Faham, S, Yang, D, Whitelegge, J.P, Bowie, J.U. | Deposit date: | 2003-08-07 | Release date: | 2004-01-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors. Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
1PXS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1pxs by Molmil](/molmil-images/mine/1pxs) | Structure of Met56Ala mutant of Bacteriorhodopsin | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Faham, S, Yang, D, Bare, E, Yohannan, S, Whitelegge, J.P, Bowie, J.U. | Deposit date: | 2003-07-06 | Release date: | 2003-12-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Side-chain Contributions to Membrane Protein Structure and Stability. J.Mol.Biol., 335, 2004
|
|
1Q5J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1q5j by Molmil](/molmil-images/mine/1q5j) | Crystal structure of bacteriorhodopsin mutant P91A crystallized from bicelles | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Yohannan, S, Faham, S, Yang, D, Whitelegge, J.P, Bowie, J.U. | Deposit date: | 2003-08-07 | Release date: | 2004-01-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors. Proc.Natl.Acad.Sci.USA, 101, 2004
|
|