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5ZB3
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BU of 5zb3 by Molmil
Dimeric crystal structure of ORF57 from KSHV
Descriptor: ORF57, ZINC ION
Authors:Gao, Z.Q, Yuan, F, Dong, Y.H, Lan, K.
Deposit date:2018-02-09
Release date:2018-08-08
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.506 Å)
Cite:The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function.
PLoS Pathog., 14, 2018
7SSA
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BU of 7ssa by Molmil
Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome
Descriptor: Centromere-binding protein 1, DNA (137-MER), Histone H2A.1, ...
Authors:Eek, P, Tan, S.
Deposit date:2021-11-10
Release date:2023-04-05
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions.
Mol.Cell, 83, 2023
5D4U
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BU of 5d4u by Molmil
SAM-bound HcgC from Methanocaldococcus jannaschii
Descriptor: S-ADENOSYLMETHIONINE, SULFATE ION, Uncharacterized protein MJ0489
Authors:Fujishiro, T, Ermler, U, Shima, S.
Deposit date:2015-08-09
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of HcgC as a SAM-Dependent Pyridinol Methyltransferase in [Fe]-Hydrogenase Cofactor Biosynthesis.
Angew.Chem.Int.Ed.Engl., 55, 2016
5D5O
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BU of 5d5o by Molmil
HcgC from Methanocaldococcus jannaschii
Descriptor: SULFATE ION, Uncharacterized protein MJ0489
Authors:Fujishiro, T, Ermler, U, Shima, S.
Deposit date:2015-08-11
Release date:2016-07-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Identification of HcgC as a SAM-Dependent Pyridinol Methyltransferase in [Fe]-Hydrogenase Cofactor Biosynthesis.
Angew.Chem.Int.Ed.Engl., 55, 2016
5D4T
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BU of 5d4t by Molmil
SeMet-labelled HcgC from Methanocaldococcus jannaschii in space group P212121
Descriptor: Uncharacterized protein MJ0489
Authors:Fujishiro, T, Ermler, U, Shima, S.
Deposit date:2015-08-09
Release date:2016-07-20
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of HcgC as a SAM-Dependent Pyridinol Methyltransferase in [Fe]-Hydrogenase Cofactor Biosynthesis.
Angew.Chem.Int.Ed.Engl., 55, 2016
7UC7
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BU of 7uc7 by Molmil
Stat5a Core in complex with Compound 17
Descriptor: GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1-benzofuran-5-yl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A
Authors:Meagher, J.L, Stuckey, J.A.
Deposit date:2022-03-16
Release date:2023-02-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
J.Med.Chem., 66, 2023
5D4V
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BU of 5d4v by Molmil
HcgC with SAH and a guanylylpyridinol (GP) derivative
Descriptor: 5'-O-[(R)-[(3,6-dimethyl-2-oxo-1,2-dihydropyridin-4-yl)oxy](hydroxy)phosphoryl]guanosine, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Fujishiro, T, Ermler, U, Shima, S.
Deposit date:2015-08-09
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of HcgC as a SAM-Dependent Pyridinol Methyltransferase in [Fe]-Hydrogenase Cofactor Biosynthesis.
Angew.Chem.Int.Ed.Engl., 55, 2016
5D5T
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BU of 5d5t by Molmil
SeMet-labelled HcgC from Methanocaldococcus jannaschii in P1 space group
Descriptor: Uncharacterized protein MJ0489
Authors:Fujishiro, T, Ermler, U, Shima, S.
Deposit date:2015-08-11
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of HcgC as a SAM-Dependent Pyridinol Methyltransferase in [Fe]-Hydrogenase Cofactor Biosynthesis.
Angew.Chem.Int.Ed.Engl., 55, 2016
3SP7
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BU of 3sp7 by Molmil
Crystal Structure of Bcl-xL bound to BM903
Descriptor: 5-(4-chlorophenyl)-4-{3-[4-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]amino}phenyl)piperazin-1-yl]phenyl}-1,2-dimethyl-1H-pyrrole-3-carboxylic acid, ACETATE ION, Bcl-2-like protein 1, ...
Authors:Meagher, J.L, Stuckey, J.A.
Deposit date:2011-07-01
Release date:2012-07-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-based design of a new class of potent Bcl-2/Bcl-xL inhibitors
To be Published
3SPF
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BU of 3spf by Molmil
Crystal Structure of Bcl-xL bound to BM501
Descriptor: 4-(4-chlorophenyl)-1-[(3S)-3,4-dihydroxybutyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-phenyl-1H-pyrrole-2-carboxamide, Bcl-2-like protein 1, GLYCEROL
Authors:Meagher, J.L, Stuckey, J.A.
Deposit date:2011-07-01
Release date:2012-06-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold.
J.Med.Chem., 55, 2012
5TCA
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BU of 5tca by Molmil
Complement Factor D inhibited with JH3
Descriptor: 1-(2-{(2S)-2-[(6-bromopyridin-2-yl)carbamoyl]-1,3-thiazolidin-3-yl}-2-oxoethyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide, Complement factor D
Authors:Stuckey, J.A.
Deposit date:2016-09-14
Release date:2016-10-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.
ACS Med Chem Lett, 7, 2016
5U8T
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BU of 5u8t by Molmil
Structure of Eukaryotic CMG Helicase at a Replication Fork and Implications
Descriptor: Cell division control protein 45, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication complex GINS protein PSF1, ...
Authors:Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, Li, H, O'Donnell, M.E.
Deposit date:2016-12-15
Release date:2017-02-08
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U8S
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BU of 5u8s by Molmil
Structure of eukaryotic CMG helicase at a replication fork
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (26-MER), ...
Authors:Li, H, Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, O'Donnell, M.E.
Deposit date:2016-12-14
Release date:2017-01-25
Last modified:2020-01-01
Method:ELECTRON MICROSCOPY (6.101 Å)
Cite:Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6IYO
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BU of 6iyo by Molmil
Crystal Structure of the acyltransferase domain from the second module of the salinomycin polyketide synthase
Descriptor: Type I modular polyketide synthase
Authors:Zhang, F, Zheng, J.
Deposit date:2018-12-17
Release date:2019-07-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Biochemistry, 58, 2019
6IYT
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BU of 6iyt by Molmil
Crystal Structure of the acyltransferase domain from second module 14 of salinomycin polyketide synthase
Descriptor: Type I modular polyketide synthase
Authors:Zhang, F, Zheng, J.
Deposit date:2018-12-17
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Biochemistry, 58, 2019
6J0U
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BU of 6j0u by Molmil
Crystal Structure of the acyltransferase domain from the third module of the ansamitocin polyketide synthase
Descriptor: PHOSPHATE ION, Type 1 modular polyketide synthase
Authors:Zhang, F, Zheng, J.
Deposit date:2018-12-26
Release date:2019-12-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural and Biochemical Insight into the Recruitment of Acyl Carrier Protein-Linked Extender Units in Ansamitocin Biosynthesis.
Chembiochem, 21, 2020
6IYR
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BU of 6iyr by Molmil
Crystal Structure of the acyltransferase domain from module 8 of the salinomycin polyketide synthase
Descriptor: PHOSPHATE ION, Type I modular polyketide synthase
Authors:Zhang, F, Zheng, J.
Deposit date:2018-12-17
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Biochemistry, 58, 2019
3SQO
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BU of 3sqo by Molmil
PCSK9 J16 Fab complex
Descriptor: J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ...
Authors:Strop, P.
Deposit date:2011-07-05
Release date:2012-05-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
J.Pharmacol.Exp.Ther., 340, 2012
7DW5
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BU of 7dw5 by Molmil
Crystal structure of DUX4 HD1-HD2 domain complexed with ERG sites
Descriptor: BROMIDE ION, DNA (5'-D(P*CP*GP*AP*CP*TP*TP*GP*AP*TP*GP*AP*GP*AP*TP*TP*AP*GP*AP*CP*TP*G)-3'), Double homeobox protein 4-like protein 2
Authors:Zhang, H, Cheng, N, Li, Z, Zhang, W, Dong, X, Huang, J, Meng, G.
Deposit date:2021-01-15
Release date:2021-11-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.
Cancer Commun (Lond), 41, 2021
7DEK
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BU of 7dek by Molmil
Pseudomonas aeruginosa FK506-binding protein PaFkbA
Descriptor: Peptidyl-prolyl cis-trans isomerase
Authors:Ynag, J, Huang, Q, Bao, R.
Deposit date:2020-11-04
Release date:2021-09-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural characterization of PaFkbA: A periplasmic chaperone from Pseudomonas aeruginosa .
Comput Struct Biotechnol J, 19, 2021
7VRS
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BU of 7vrs by Molmil
The complex of Acyltransferase and Acyl Carrier Protein Domains from module 9 of Salinomycin Polyketide Synthase
Descriptor: 1,1'-butane-1,4-diylbis(1H-pyrrole-2,5-dione), 4'-PHOSPHOPANTETHEINE, Type I modular polyketide synthase
Authors:Feng, Y, Zheng, J.
Deposit date:2021-10-24
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural visualization of transient interactions between the cis-acting acyltransferase and acyl carrier protein of the salinomycin modular polyketide synthase.
Acta Crystallogr D Struct Biol, 78, 2022
7VT1
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BU of 7vt1 by Molmil
Acyltransferase from the 9th Module of Salinomycin Polyketide Synthase
Descriptor: Type I modular polyketide synthase
Authors:Feng, Y, Zhang, F, Zheng, J.
Deposit date:2021-10-27
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural visualization of transient interactions between the cis-acting acyltransferase and acyl carrier protein of the salinomycin modular polyketide synthase.
Acta Crystallogr D Struct Biol, 78, 2022
7WD9
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BU of 7wd9 by Molmil
SARS-CoV-2 Beta spike in complex with three S3H3 Fabs
Descriptor: Heavy chain of S3H3 Fab, Light chain of S3H3 Fab, Spike glycoprotein
Authors:Wang, Y.F, Cong, Y.
Deposit date:2021-12-21
Release date:2022-02-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein.
Emerg Microbes Infect, 11, 2022
7WD7
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BU of 7wd7 by Molmil
SARS-CoV-2 Beta spike in complex with three S5D2 Fabs
Descriptor: Heavy chain of S5D2 Fab, Light chain of S5D2 Fab, Spike glycoprotein
Authors:Wang, Y.F, Cong, Y.
Deposit date:2021-12-21
Release date:2022-02-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein.
Emerg Microbes Infect, 11, 2022
7WDF
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BU of 7wdf by Molmil
SARS-CoV-2 Beta spike in complex with two S3H3 Fabs
Descriptor: Heavy chain of S3H3 Fab, Light chain of S3H3 Fab, Spike glycoprotein
Authors:Wang, Y.F, Cong, Y.
Deposit date:2021-12-21
Release date:2022-02-02
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein.
Emerg Microbes Infect, 11, 2022

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