5TCA

Complement Factor D inhibited with JH3

Summary for 5TCA

• Entry DOI: 10.2210/pdb5tca/pdb
• Related: 5TCC
• Descriptor: Complement factor D, 1-(2-{(2S)-2-[(6-bromopyridin-2-yl)carbamoyl]-1,3-thiazolidin-3-yl}-2-oxoethyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: serine protease, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 7
• Total formula weight: 175484.65

Authors

Stuckey, J.A. (deposition date: 2016-09-14, release date: 2016-10-19, Last modification date: 2023-10-04)

• Primary citation: Yang, C.Y.,Phillips, J.G.,Stuckey, J.A.,Bai, L.,Sun, H.,Delproposto, J.,Brown, W.C.,Chinnaswamy, K.; Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.; ACS Med Chem Lett, 7:1092-1096, 2016; PubMed: 27994744; DOI: 10.1021/acsmedchemlett.6b00299

Experimental method

X-RAY DIFFRACTION (3.15 Å)