4QME
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![BU of 4qme by Molmil](/molmil-images/mine/4qme) | Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe | Descriptor: | (2S)-3-[(S)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, Aminopeptidase N, GLYCEROL, ... | Authors: | Nocek, B, Vassilious, S, Mulligan, R, Berlicki, L, Mucha, A, Joachimiak, A. | Deposit date: | 2014-06-16 | Release date: | 2014-10-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
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7Y8X
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![BU of 7y8x by Molmil](/molmil-images/mine/7y8x) | Crystal structure of AlbEF homolog from Quasibacillus thermotolerans in complex with Ni(II) | Descriptor: | 1,2-ETHANEDIOL, AlbE homolog, AlbF homolog, ... | Authors: | Ishida, K, Nakamura, A, Kojima, S. | Deposit date: | 2022-06-24 | Release date: | 2022-10-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of the AlbEF complex involved in subtilosin A biosynthesis. Structure, 30, 2022
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4QN8
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![BU of 4qn8 by Molmil](/molmil-images/mine/4qn8) | The crystal structure of an effector protein VipE from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 | Descriptor: | BETA-MERCAPTOETHANOL, VipE | Authors: | Tan, K, Xu, X, Cui, H, Liu, S, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-06-17 | Release date: | 2014-07-16 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | The crystal structure of an effector protein VipE from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 To be Published
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7YF6
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![BU of 7yf6 by Molmil](/molmil-images/mine/7yf6) | Crystal structure of HIV-1 protease in complex with macrocyclic peptide | Descriptor: | MAGNESIUM ION, Macrocyclic Peptide, Protease | Authors: | Kusumoto, Y, Sato, S, Yamada, T, Kozono, I, Nakata, Z, Asada, N, Mitsuki, S, Wakasa-Morimoto, C, Tohru, M, Watanabe, A, Hayashi, K, Mikamiyama, H. | Deposit date: | 2022-07-07 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization. Acs Med.Chem.Lett., 13, 2022
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4RTE
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![BU of 4rte by Molmil](/molmil-images/mine/4rte) | |
3CQY
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![BU of 3cqy by Molmil](/molmil-images/mine/3cqy) | Crystal structure of a functionally unknown protein (SO_1313) from Shewanella oneidensis MR-1 | Descriptor: | Anhydro-N-acetylmuramic acid kinase, CHLORIDE ION, SUCCINIC ACID | Authors: | Tan, K, Evdokimova, E, Kudritska, M, Savchenko, A, Edwards, A.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-04-03 | Release date: | 2008-04-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The structure of a functionally unknown protein (SO_1313) from Shewanella oneidensis MR-1. To be Published
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2QCB
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![BU of 2qcb by Molmil](/molmil-images/mine/2qcb) | T7-tagged full-length streptavidin complexed with ruthenium ligand | Descriptor: | N-(4-{[(2-AMINOETHYL)AMINO]SULFONYL}PHENYL)-5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANAMIDE-(1,2,3,4,5,6-ETA)-BENZENE-CHLORO-RUTHENIUM(III), Streptavidin | Authors: | Le Trong, I, Creus, M, Pordea, A, Ward, T.R, Stenkamp, R.E. | Deposit date: | 2007-06-19 | Release date: | 2008-04-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | X-ray structure and designed evolution of an artificial transfer hydrogenase Angew.Chem.Int.Ed.Engl., 47, 2008
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4S38
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![BU of 4s38 by Molmil](/molmil-images/mine/4s38) | IspG in complex MEcPP | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, ... | Authors: | Quitterer, F, Frank, A, Wang, K, Guodong, R, O'Dowd, B, Li, J, Guerra, F, Abdel-Azeim, S, Bacher, A, Eppinger, J, Oldfield, E, Groll, M. | Deposit date: | 2015-01-26 | Release date: | 2015-04-29 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE). J.Mol.Biol., 427, 2015
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3CUO
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![BU of 3cuo by Molmil](/molmil-images/mine/3cuo) | Crystal structure of the predicted DNA-binding transcriptional regulator from E. coli | Descriptor: | Uncharacterized HTH-type transcriptional regulator ygaV | Authors: | Zhang, R, Evdokimova, E, Kagan, O, Savchenko, A, Edwards, A.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-04-16 | Release date: | 2008-06-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of the predicted DNA-binding transcriptional regulator from E. coli. To be Published
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4RZ7
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![BU of 4rz7 by Molmil](/molmil-images/mine/4rz7) | Crystal Structure of PVX_084705 with bound PCI32765 | Descriptor: | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, UNKNOWN ATOM OR ION, cGMP-dependent protein kinase, ... | Authors: | Jiang, D.Q, Tempel, W, Loppnau, P, Graslund, S, He, H, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Amani, M, Structural Genomics Consortium (SGC) | Deposit date: | 2014-12-18 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.351 Å) | Cite: | Crystal Structure of PVX_084705 with bound PCI32765 To be Published
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1NQP
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![BU of 1nqp by Molmil](/molmil-images/mine/1nqp) | Crystal structure of Human hemoglobin E at 1.73 A resolution | Descriptor: | CYANIDE ION, Hemoglobin alpha chain, Hemoglobin beta chain, ... | Authors: | Dasgupta, J, Sen, U, Choudhury, D, Dutta, P, Basu, S, Chakrabarti, A, Chakrabarty, A, Dattagupta, J.K. | Deposit date: | 2003-01-22 | Release date: | 2004-03-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Crystallization and preliminary X-ray structural Studies of Hemoglobin A2 and Hemoglobin E, isolated from the blood samples of Beta-thalassemic patients Biochem.Biophys.Res.Commun., 303, 2004
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4S3D
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![BU of 4s3d by Molmil](/molmil-images/mine/4s3d) | IspG in complex with PPi | Descriptor: | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, DIPHOSPHATE, FE3-S4 CLUSTER | Authors: | Quitterer, F, Frank, A, Wang, K, Rao, G, O'Dowd, B, Li, J, Guerra, F, Abdel-Azeim, S, Bacher, A, Eppinger, J, Oldfield, E, Groll, M. | Deposit date: | 2015-01-26 | Release date: | 2015-04-29 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE). J.Mol.Biol., 427, 2015
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3A9C
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![BU of 3a9c by Molmil](/molmil-images/mine/3a9c) | Crystal structure of ribose-1,5-bisphosphate isomerase from Thermococcus kodakaraensis KOD1 in complex with ribulose-1,5-bisphosphate | Descriptor: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, RIBULOSE-1,5-DIPHOSPHATE, ... | Authors: | Nakamura, A, Fujihashi, M, Nishiba, Y, Yoshida, S, Yano, A, Atomi, H, Imanaka, T, Miki, K. | Deposit date: | 2009-10-22 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1 J.Biol.Chem., 287, 2012
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4JFJ
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![BU of 4jfj by Molmil](/molmil-images/mine/4jfj) | Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound (1S,6R)-10-(1,3-benzothiazol-6-ylsulfonyl)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one | Descriptor: | (1S,6R)-10-(1,3-benzothiazol-6-ylsulfonyl)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F. | Deposit date: | 2013-02-28 | Release date: | 2013-08-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. J.Med.Chem., 56, 2013
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7Y3J
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![BU of 7y3j by Molmil](/molmil-images/mine/7y3j) | 24B3 antibody-peptide complex | Descriptor: | 24B3 Heavy chain, 24B3 Light chain, ALA-LEU-VAL-PHE-PHE-ALA-PRO-ALA-VAL-GLY-SER | Authors: | Irie, K, Irie, Y, Kita, A, Miki, K. | Deposit date: | 2022-06-11 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of the 24B3 antibody against the toxic conformer of amyloid beta with a turn at positions 22 and 23. Biochem.Biophys.Res.Commun., 621, 2022
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3IHC
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![BU of 3ihc by Molmil](/molmil-images/mine/3ihc) | |
1Z1Z
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![BU of 1z1z by Molmil](/molmil-images/mine/1z1z) | |
2QMO
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![BU of 2qmo by Molmil](/molmil-images/mine/2qmo) | Crystal structure of dethiobiotin synthetase (bioD) from Helicobacter pylori | Descriptor: | CHLORIDE ION, Dethiobiotin synthetase | Authors: | Chruszcz, M, Xu, X, Cuff, M, Cymborowski, M, Zheng, H, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2007-07-16 | Release date: | 2007-07-31 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members. Febs J., 279, 2012
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7YKE
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![BU of 7yke by Molmil](/molmil-images/mine/7yke) | Crystal structure of chondroitin ABC lyase I in complex with chondroitin disaccharide 4,6-sulfate | Descriptor: | 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4,6-di-O-sulfo-beta-D-galactopyranose, Chondroitin sulfate ABC endolyase, MAGNESIUM ION | Authors: | Takashima, M, Watanabe, I, Miyanaga, A, Eguchi, T. | Deposit date: | 2022-07-22 | Release date: | 2022-11-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Biochemical and crystallographic assessments of the effect of 4,6-O-disulfated disaccharide moieties in chondroitin sulfate E on chondroitinase ABC I activity. Febs J., 290, 2023
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3AE4
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![BU of 3ae4 by Molmil](/molmil-images/mine/3ae4) | Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-methyl-benzamide | Descriptor: | 2-iodo-N-methylbenzamide, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | Authors: | Harada, S, Sasaki, T, Shindo, M, Kido, Y, Inaoka, D.K, Omori, J, Osanai, A, Sakamoto, K, Mao, J, Matsuoka, S, Inoue, M, Honma, T, Tanaka, A, Kita, K. | Deposit date: | 2010-02-04 | Release date: | 2011-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-methyl-benzamide To be Published
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3WZD
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![BU of 3wzd by Molmil](/molmil-images/mine/3wzd) | KDR in complex with ligand lenvatinib | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide, ... | Authors: | Okamoto, K, Ikemori_Kawada, M, Inoue, A, Matsui, J. | Deposit date: | 2014-09-24 | Release date: | 2015-05-27 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization. ACS MED.CHEM.LETT., 6, 2015
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3AGM
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![BU of 3agm by Molmil](/molmil-images/mine/3agm) | Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670 | Descriptor: | N~2~-{8-OXO-8-[4-(9H-PURIN-6-YL)PIPERAZIN-1-YL]OCTANOYL}-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGININAMIDE, cAMP-dependent protein kinase catalytic subunit alpha | Authors: | Pflug, A, Ragozina, J, Uri, A, Bossemeyer, D, Engh, R.A. | Deposit date: | 2010-04-02 | Release date: | 2010-09-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions. J.Mol.Biol., 403, 2010
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1MSF
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![BU of 1msf by Molmil](/molmil-images/mine/1msf) | SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES | Descriptor: | C-Myb DNA-Binding Domain, DNA (5'-D(*AP*TP*GP*TP*GP*TP*GP*TP*CP*AP*GP*TP*TP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*AP*AP*CP*TP*GP*AP*CP*AP*CP*AP*CP*AP*T)-3') | Authors: | Ogata, K, Morikawa, S, Nakamura, H, Sekikawa, A, Inoue, T, Kanai, H, Sarai, A, Ishii, S, Nishimura, Y. | Deposit date: | 1995-01-24 | Release date: | 1995-03-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell(Cambridge,Mass.), 79, 1994
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2FJC
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![BU of 2fjc by Molmil](/molmil-images/mine/2fjc) | Crystal structure of antigen TpF1 from Treponema pallidum | Descriptor: | Antigen TpF1, FE (III) ION | Authors: | Thumiger, A, Polenghi, A, Papinutto, E, Battistutta, R, Montecucco, C, Zanotti, G. | Deposit date: | 2006-01-02 | Release date: | 2006-01-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of antigen TpF1 from Treponema pallidum. Proteins, 62, 2006
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2FGL
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![BU of 2fgl by Molmil](/molmil-images/mine/2fgl) | An alkali thermostable F/10 xylanase from alkalophilic Bacillus sp. NG-27 | Descriptor: | MAGNESIUM ION, alkaline thermostable endoxylanase, alpha-D-xylopyranose, ... | Authors: | Ramakumar, S, Manikandan, K, Bhardwaj, A, Reddy, V.S, Lokanath, N.K, Ghosh, A. | Deposit date: | 2005-12-22 | Release date: | 2006-09-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of native and xylosaccharide-bound alkali thermostable xylanase from an alkalophilic Bacillus sp. NG-27: structural insights into alkalophilicity and implications for adaptation to polyextreme conditions. Protein Sci., 15, 2006
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