7YF6

Crystal structure of HIV-1 protease in complex with macrocyclic peptide

Summary for 7YF6

Entry DOI	10.2210/pdb7yf6/pdb
Descriptor	Protease, Macrocyclic Peptide, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	3
Total formula weight	22837.33
Authors	Kusumoto, Y.,Sato, S.,Yamada, T.,Kozono, I.,Nakata, Z.,Asada, N.,Mitsuki, S.,Wakasa-Morimoto, C.,Tohru, M.,Watanabe, A.,Hayashi, K.,Mikamiyama, H. (deposition date: 2022-07-07, release date: 2022-11-02, Last modification date: 2023-11-29)
Primary citation	Kusumoto, Y.,Hayashi, K.,Sato, S.,Yamada, T.,Kozono, I.,Nakata, Z.,Asada, N.,Mitsuki, S.,Watanabe, A.,Wakasa-Morimoto, C.,Uemura, K.,Arita, S.,Miki, S.,Mizutare, T.,Mikamiyama, H. Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization. Acs Med.Chem.Lett., 13:1634-1641, 2022 Cited by PubMed: 36262395 DOI: 10.1021/acsmedchemlett.2c00310 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation